Publications by authors named "Austin Dosch"

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Brave New World: Analysis of Early Clinical Experience With Molecular Sequencing in the Treatment of Rectal Cancer.
Jared T Yee, Ahmed A Eltahir, Oluseye K Oduyale, Austin R Dosch, Nathan S Kau

Dis Colon Rectum· December 2025

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Targeting CREB remodels the immune microenvironment to enhance immunotherapy responses in pancreatic cancer.
Siddharth Mehra, Supriya Srinivasan, Sudhakar Jinka, Varunkumar Krishnamoorthy, Vineet Kumar Gupta, Austin R Dosch

bioRxiv· December 2025

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CREB Drives Acinar to Ductal Cells Reprogramming and Promotes Pancreatic Cancer Progression in Preclinical Models of Alcoholic Pancreatitis.
Supriya Srinivasan, Siddharth Mehra, Sudhakar Jinka, Anna Bianchi, Samara Singh, Austin R Dosch

Cell Mol Gastroenterol Hepatol· November 2025

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CREB drives acinar cells to ductal reprogramming and promotes pancreatic cancer progression in preclinical models of alcoholic pancreatitis.
Supriya Srinivasan, Siddharth Mehra, Sudhakar Jinka, Anna Bianchi, Samara Singh, Austin R Dosch

bioRxiv· July 2025

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Nonoperative Management of Rectal Cancer: Is "Near-Complete" Response Safe to Surveil?
Catherine N Zivanov, Nathan S Kau, Harika Nalluri-Butz, Oluseye K Oduyale, Ahmed A Eltahir, Austin R Dosch

Ann Surg Oncol· July 2025

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The Role of Myeloid Cells on the Development of Hepatic Metastases in Gastrointestinal Cancer.
Austin R Dosch, Mary P Martos, Samara Singh, Karishma Kodia, Nipun B Merchant

Gastro Hep Adv· August 2024

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Nationwide Outcomes After Neoadjuvant Chemotherapy for Locally Advanced Sigmoid Colon Cancer-A Propensity Score-Matched Analysis.
Karishma Kodia, Ahmed Alnajar, Carlos T Huerta, Gaurav Gupta, Bhuwan Giri, Austin Dosch

Am Surg· April 2024

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Tumor Cell-Intrinsic p38 MAPK Signaling Promotes IL1α-Mediated Stromal Inflammation and Therapeutic Resistance in Pancreatic Cancer.
Samara P Singh, Austin R Dosch, Siddharth Mehra, Iago De Castro Silva, Anna Bianchi

Cancer Res· April 2024

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Remodeling of Stromal Immune Microenvironment by Urolithin A Improves Survival with Immune Checkpoint Blockade in Pancreatic Cancer.
Siddharth Mehra, Vanessa T Garrido, Austin R Dosch, Purushottam Lamichhane, Supriya Srinivasan

Cancer Res Commun· July 2023

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Cell-Autonomous Cxcl1 Sustains Tolerogenic Circuitries and Stromal Inflammation via Neutrophil-Derived TNF in Pancreatic Cancer.
Anna Bianchi, Iago De Castro Silva, Nilesh U Deshpande, Samara Singh, Siddharth Mehra, Austin R Dosch

Cancer Discov· June 2023

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Combined MEK and STAT3 Inhibition Uncovers Stromal Plasticity by Enriching for Cancer-Associated Fibroblasts With Mesenchymal Stem Cell-Like Features to Overcome Immunotherapy Resistance in Pancreatic Cancer.
Jashodeep Datta, Xizi Dai, Anna Bianchi, Iago De Castro Silva, Siddharth Mehra, Austin R Dosch

Gastroenterology· December 2022

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Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling.
Siddharth Mehra, Supriya Srinivasan, Samara Singh, Zhiqun Zhou, Vanessa Garrido, Austin R Dosch

Am J Physiol Gastrointest Liver Physiol· October 2022

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Distinct mechanisms of innate and adaptive immune regulation underlie poor oncologic outcomes associated with KRAS-TP53 co-alteration in pancreatic cancer.
Jashodeep Datta, Anna Bianchi, Iago De Castro Silva, Nilesh U Deshpande, Long Long Cao, Austin R Dosch

Oncogene· July 2022

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Trauma patients with human immunodeficiency virus (HIV): a propensity matched analysis.
Jose Covarrubias, Areg Grigorian, Catherine M Kuza, Matthew Dolich, Austin Dosch

Eur J Trauma Emerg Surg· February 2022

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Interleukin-1 signaling in solid organ malignancies.
Austin R Dosch, Samara Singh, Nagaraj S Nagathihalli, Jashodeep Datta, Nipun B Merchant

Biochim Biophys Acta Rev Cancer· January 2022

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Targeting Tumor-Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer.
Austin R Dosch, Samara Singh, Xizi Dai, Siddharth Mehra, Iago De Castro Silva

Mol Cancer Ther· November 2021

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Ras-p53 genomic cooperativity as a model to investigate mechanisms of innate immune regulation in gastrointestinal cancers.
Austin R Dosch, Walid K Chatila, Yuguang Ban, Anna Bianchi, Nilesh U Deshpande

Oncotarget· September 2021

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Combined Blockade of MEK and CDK4/6 Pathways Induces Senescence to Improve Survival in Pancreatic Ductal Adenocarcinoma.
Brent A Willobee, Alexander A Gaidarski, Austin R Dosch, Jason A Castellanos, Xizi Dai

Mol Cancer Ther· July 2021

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Revisiting the Surgical Infection Society Delphi Analysis of the Research Agenda in Surgical Infections: Advancements and Unanswered Questions.
Patrick T Delaplain, Austin R Dosch, Haytham M A Kaafarani, Philip S Barie, Sebastian D Schubl

Surg Infect (Larchmt)· April 2021

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The Role of Perioperative Chemotherapy in the Management of Colloid Carcinoma of the Pancreas.
Omar Picado, Austin R Dosch, Monica T Garcia-Buitrago, Danny Yakoub, Vikas Dudeja

Pancreas· March 2021

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Stroma secreted IL6 selects for "stem-like" population and alters pancreatic tumor microenvironment by reprogramming metabolic pathways.
Kousik Kesh, Vanessa T Garrido, Austin Dosch, Brittany Durden, Vineet K Gupta

Cell Death Dis· November 2020

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Minimally Invasive Surgery is Associated with an Increased Risk of Postoperative Venous Thromboembolism After Distal Pancreatectomy.
Brent A Willobee, Austin R Dosch, Casey J Allen, Francisco I Macedo, Tyler S Bartholomew

Ann Surg Oncol· July 2020

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Deciphering high risk molecular alterations in gastrointestinal malignancy utilizing an extreme outlier strategy.
Austin R Dosch, Siddharth Mehra, Nipun B Merchant, Jashodeep Datta

Oncoscience· May 2020

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Combined Src/EGFR Inhibition Targets STAT3 Signaling and Induces Stromal Remodeling to Improve Survival in Pancreatic Cancer.
Austin R Dosch, Xizi Dai, Michelle L Reyzer, Siddharth Mehra, Supriya Srinivasan

Mol Cancer Res· April 2020

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The use of computed tomography imaging for abdominal seatbelt sign: A single-center, prospective evaluation.
Patrick T Delaplain, Cristobal Barrios, Dean Spencer, Michael Lekawa, Sebastian Schubl, Austin Dosch

Injury· January 2020

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