Publications by authors named "Axel Abelein"

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Chaperone-Mediated Regulation of Tau Phase Separation, Fibrillation, and Toxicity.
Cecilia Mörman, Axel Leppert, Giusy Pizzirusso, Zihan Zheng, Xun Sun, Axel Abelein

J Am Chem Soc· July 2025

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CagA protein is a potent and broad-spectrum amyloid inhibitor.
Zhen Jin, William Pallisgaard Olsen, Cecilia Mörman, Axel Leppert, Rakesh Kumar, Axel Abelein

Sci Adv· June 2025

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Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS.
Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Axel Abelein

Protein Sci· August 2024

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Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain.
Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Axel Abelein

Protein Sci· July 2024

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Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain.
Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Axel Abelein

Nat Commun· February 2024

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Metal Binding of Alzheimer's Amyloid-β and Its Effect on Peptide Self-Assembly.
Axel Abelein

Acc Chem Res· October 2023

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A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain.
Axel Leppert, Helen Poska, Michael Landreh, Axel Abelein, Gefei Chen

Protein Sci· June 2023

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Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation.
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Axel Abelein

Commun Biol· May 2023

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Amyloid inhibition by molecular chaperones can be translated to Alzheimer's pathology .
Axel Abelein, Jan Johansson

RSC Med Chem· May 2023

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Misfolded alpha-synuclein detection by RT-QuIC in dementia with lewy bodies: a systematic review and meta-analysis.
Carmen Peña-Bautista, Rakesh Kumar, Miguel Baquero, Jan Johansson, Consuelo Cháfer-Pericás, Axel Abelein

Front Mol Biosci· May 2023

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Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone.
Rakesh Kumar, Luis Enrique Arroyo-García, Shaffi Manchanda, Laurène Adam, Giusy Pizzirusso, Axel Abelein

ACS Chem Neurosci· April 2023

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Intravenous treatment with a molecular chaperone designed against β-amyloid toxicity improves Alzheimer's disease pathology in mouse models.
Shaffi Manchanda, Lorena Galan-Acosta, Axel Abelein, Simone Tambaro, Gefei Chen

Mol Ther· February 2023

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Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.
Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Axel Abelein

RSC Chem Biol· November 2022

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Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.
Axel Abelein, Simone Ciofi-Baffoni, Cecilia Mörman, Rakesh Kumar, Andrea Giachetti

JACS Au· November 2022

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Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain.
Xueying Zhong, Rakesh Kumar, Yu Wang, Henrik Biverstål, Caroline Ingeborg Jegerschöld, Axel Abelein

ACS Chem Biol· August 2022

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Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform.
Tina Arndt, Kristaps Jaudzems, Olga Shilkova, Juanita Francis, Mathias Johansson, Axel Abelein

Nat Commun· August 2022

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Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration.
Mirjam Brackhan, Giulio Calza, Kristiina Lundgren, Pablo Bascuñana, Thomas Brüning, Axel Abelein

EMBO Rep· July 2022

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Increased CSF-decorin predicts brain pathological changes driven by Alzheimer's Aβ amyloidosis.
Richeng Jiang, Una Smailovic, Hazal Haytural, Betty M Tijms, Hao Li, Axel Abelein

Acta Neuropathol Commun· July 2022

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A "spindle and thread" mechanism unblocks p53 translation by modulating N-terminal disorder.
Margit Kaldmäe, Thibault Vosselman, Xueying Zhong, Dilraj Lama, Gefei Chen, Axel Abelein

Structure· May 2022

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Autophagy Impairment in Knock-in Alzheimer's Model Mice.
Richeng Jiang, Makoto Shimozawa, Johanna Mayer, Simone Tambaro, Rakesh Kumar, Axel Abelein

Front Aging Neurosci· May 2022

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The synthesis and characterization of Bri2 BRICHOS coated magnetic particles and their application to protein fishing: Identification of novel binding proteins.
Helene Tigro, Nina Kronqvist, Axel Abelein, Lorena Galan-Acosta, Gefei Chen

J Pharm Biomed Anal· May 2021

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Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain.
Axel Leppert, Ann Tiiman, Nina Kronqvist, Michael Landreh, Axel Abelein

Biochemistry· March 2021

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Functionalization of amyloid fibrils via the Bri2 BRICHOS domain.
Henrik Biverstål, Rakesh Kumar, Anna Katharina Schellhaus, Médoune Sarr, Nico P Dantuma, Axel Abelein

Sci Rep· December 2020

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Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation-inert complex.
Cecilia Wallin, Jüri Jarvet, Henrik Biverstål, Sebastian Wärmländer, Jens Danielsson, Axel Abelein

J Biol Chem· May 2020

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Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.
Gefei Chen, Yuniesky Andrade-Talavera, Simone Tambaro, Axel Leppert, Harriet E Nilsson, Axel Abelein

Commun Biol· January 2020

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