Publications by authors named "Helen Poska"

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Bri2 BRICHOS, a molecular chaperone-like domain that can cross brain vascular endothelial cells and deliver proteins into neurons.
Helene Tigro, Cloé Moëlo, Josef Pelcman, Wojciech Paslawski, Gefei Chen, Helen Poska

J Control Release· December 2025

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A new kid in the folding funnel: Molecular chaperone activities of the BRICHOS domain.
Axel Leppert, Helen Poska, Michael Landreh, Axel Abelein, Gefei Chen

Protein Sci· June 2023

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Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation.
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira

Commun Biol· May 2023

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Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.
Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Helen Poska

RSC Chem Biol· November 2022

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Thioredoxin-80 protects against amyloid-beta pathology through autophagic-lysosomal pathway regulation.
Gorka Gerenu, Torbjörn Persson, Julen Goikolea, Javier Calvo-Garrido, Raúl Loera-Valencia, Helen Poska

Mol Psychiatry· April 2021

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Recombinant Bri3 BRICHOS domain is a molecular chaperone with effect against amyloid formation and non-fibrillar protein aggregation.
Helen Poska, Axel Leppert, Helene Tigro, Xueying Zhong, Margit Kaldmäe

Sci Rep· June 2020

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Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila.
Helen Poska, Martin Haslbeck, Firoz Roshan Kurudenkandy, Erik Hermansson, Gefei Chen

Biochem J· October 2016

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Amyloid β25-35 induced ROS-burst through NADPH oxidase is sensitive to iron chelation in microglial Bv2 cells.
Kristin Part, Kai Künnis-Beres, Helen Poska, Tiit Land, Ruth Shimmo

Brain Res· December 2015

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