Publications by authors named "Azad Bonni"

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The UBE3A-ATS antisense oligonucleotide rugonersen in children with Angelman syndrome: a phase 1 trial.
Jörg F Hipp, Carlos A Bacino, Lynne M Bird, Ina Bruenig-Traebert, Daniel Chan, Azad Bonni

Nat Med· September 2025

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Author Correction: Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson's disease trials.
Gennaro Pagano, Dylan Trundell, Tanya Simuni, Nicola Pavese, Kenneth Marek, Azad Bonni

NPJ Parkinsons Dis· August 2025

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Angelman syndrome patient-derived neuron screen leads to clinical ASO rugonersen targeting UBE3A-ATS with long-lasting effect in monkeys.
Ravi Jagasia, Charlotte Bon, Soren V Rasmussen, Solveig Badillo, Disa Tehler, Azad Bonni

Nucleic Acids Res· August 2025

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Time-to-event analysis mitigates the impact of symptomatic therapy on therapeutic benefit in Parkinson's disease trials.
Gennaro Pagano, Dylan Trundell, Tanya Simuni, Nicola Pavese, Kenneth Marek, Azad Bonni

NPJ Parkinsons Dis· July 2025

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Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Azad Bonni

Lancet Neurol· April 2025

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A Phase 2b, multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of intravenous prasinezumab in early-stage Parkinson's disease (PADOVA): Rationale, design, and baseline data.
Tania Nikolcheva, Gennaro Pagano, Nathalie Pross, Tanya Simuni, Kenneth Marek, Azad Bonni

Parkinsonism Relat Disord· March 2025

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The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.
Hao Chen, Cole J Ferguson, Dylan C Mitchell, Isabel Risch, Amanda Titus, Azad Bonni

Cell Rep· February 2025

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Corrigendum: Identification of a PTEN-regulated STAT brain tumor suppressor pathway.
Núria de la Iglesia, Genevieve Konopka, Sidharth V Puram, Jennifer A Chan, Robert M Bachoo, Azad Bonni

Genes Dev· February 2025

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Safety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial.
Randall J Bateman, Yan Li, Eric M McDade, Jorge J Llibre-Guerra, David B Clifford, Azad Bonni

medRxiv· January 2025

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Sustained effect of prasinezumab on Parkinson's disease motor progression in the open-label extension of the PASADENA trial.
Gennaro Pagano, Annabelle Monnet, Adriana Reyes, Benjamin Ribba, Hanno Svoboda, Azad Bonni

Nat Med· December 2024

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The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway.
Hao Chen, Cole J Ferguson, Dylan C Mitchell, Amanda Titus, Joao A Paulo, Azad Bonni

bioRxiv· June 2024

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Prasinezumab slows motor progression in rapidly progressing early-stage Parkinson's disease.
Gennaro Pagano, Kirsten I Taylor, Judith Anzures Cabrera, Tanya Simuni, Kenneth Marek, Azad Bonni

Nat Med· April 2024

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PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS.
Dilan Rasool, Audrey Burban, Ahmad Sharanek, Ariel Madrigal, Jinghua Hu, Azad Bonni

EMBO Rep· March 2024

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The anaphase-promoting complex controls a ubiquitination-phosphoprotein axis in chromatin during neurodevelopment.
Leya Ledvin, Brandon M Gassaway, Jonathan Tawil, Olivia Urso, Donald Pizzo, Azad Bonni

Dev Cell· December 2023

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Targeted ASO-mediated Atp1a2 knockdown in astrocytes reduces SOD1 aggregation and accelerates disease onset in mutant SOD1 mice.
Abhirami K Iyer, Kathleen M Schoch, Anthony Verbeck, Grant Galasso, Hao Chen, Azad Bonni

PLoS One· December 2023

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MeCP2 represses the activity of topoisomerase IIβ in long neuronal genes.
Sabin A Nettles, Yoshiho Ikeuchi, Katheryn B Lefton, Ladan Abbasi, Alyssa Erickson, Azad Bonni

Cell Rep· December 2023

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Increased G3BP2-Tau interaction in tauopathies is a natural defense against Tau aggregation.
Congwei Wang, Marco Terrigno, Juan Li, Tania Distler, Nikhil J Pandya, Azad Bonni

Neuron· September 2023

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Sumoylated SnoN interacts with HDAC1 and p300/CBP to regulate EMT-associated phenotypes in mammary organoids.
Ayan Chanda, Anusi Sarkar, Lili Deng, Azad Bonni, Shirin Bonni

Cell Death Dis· July 2023

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This is NOT the End for Immunotherapy in Parkinson's Disease - A Perspective from Early Drug Development Scientists.
Patrik Brundin, Hanno Svoboda, Azad Bonni, Gennaro Pagano

J Parkinsons Dis· December 2022

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Trial of Prasinezumab in Early-Stage Parkinson's Disease.
Gennaro Pagano, Kirsten I Taylor, Judith Anzures-Cabrera, Maddalena Marchesi, Tanya Simuni, Azad Bonni

N Engl J Med· August 2022

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Transcriptomic mapping uncovers Purkinje neuron plasticity driving learning.
Xiaoying Chen, Yanhua Du, Gerard Joey Broussard, Mikhail Kislin, Carla M Yuede, Azad Bonni

Nature· May 2022

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APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.
Cole J Ferguson, Olivia Urso, Tatyana Bodrug, Brandon M Gassaway, Edmond R Watson, Azad Bonni

Mol Cell· January 2022

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A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data.
Gennaro Pagano, Frank G Boess, Kirsten I Taylor, Benedicte Ricci, Brit Mollenhauer, Azad Bonni

Front Neurol· October 2021

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CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum.
Naveen C Reddy, Shahriyar P Majidi, Lingchun Kong, Mati Nemera, Cole J Ferguson, Azad Bonni

Nat Commun· September 2021

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Altered neuronal physiology, development, and function associated with a common chromosome 15 duplication involving CHRNA7.
Kesavan Meganathan, Ramachandran Prakasam, Dustin Baldridge, Paul Gontarz, Bo Zhang, Azad Bonni

BMC Biol· July 2021

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