Publications by authors named "Edmond R Watson"

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Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders.
Bryan J Simmons, Lynda Groocock, Jesus Moreno, David S Peters, Meredith E Hughes, Edmond R Watson

J Med Chem· December 2025

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Golcadomide: An Oral CELMoD Agent Targeting IKZF1/3 For Diffuse Large B-Cell Lymphoma.
Zhongying Mo, Lynda Groocock, Scott Wood, Diana Jankeel, Derek Mendy, Edmond R Watson

Blood Cancer Discov· November 2025

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Bis-sulfonamido-2-phenylbenzoxazoles Validate the GroES/EL Chaperone System as a Viable Antibiotic Target.
Jack Godek, Jared Sivinski, Edmond R Watson, Felicidad Lebario, Wenli Xu

J Am Chem Soc· July 2024

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Molecular glue CELMoD compounds are regulators of cereblon conformation.
Edmond R Watson, Scott Novick, Mary E Matyskiela, Philip P Chamberlain, Andres H de la Peña

Science· November 2022

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Allosteric differences dictate GroEL complementation of E. coli.
Jared Sivinski, Duc Ngo, Christopher J Zerio, Andrew J Ambrose, Edmond R Watson

FASEB J· March 2022

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APC7 mediates ubiquitin signaling in constitutive heterochromatin in the developing mammalian brain.
Cole J Ferguson, Olivia Urso, Tatyana Bodrug, Brandon M Gassaway, Edmond R Watson

Mol Cell· January 2022

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Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Mia Shin, Edmond R Watson, Albert S Song, Jeffrey T Mindrebo, Scott J Novick

Nat Commun· May 2021

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Gene expression and cell identity controlled by anaphase-promoting complex.
Eugene Oh, Kevin G Mark, Annamaria Mocciaro, Edmond R Watson, J Rajan Prabu

Nature· March 2020

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Protein engineering of a ubiquitin-variant inhibitor of APC/C identifies a cryptic K48 ubiquitin chain binding site.
Edmond R Watson, Christy R R Grace, Wei Zhang, Darcie J Miller, Iain F Davidson

Proc Natl Acad Sci U S A· August 2019

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Posing the APC/C E3 Ubiquitin Ligase to Orchestrate Cell Division.
Edmond R Watson, Nicholas G Brown, Jan-Michael Peters, Holger Stark, Brenda A Schulman

Trends Cell Biol· February 2019

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Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C.
Nicholas G Brown, Ryan VanderLinden, Edmond R Watson, Florian Weissmann, Alban Ordureau

Cell· June 2016

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Measuring APC/C-Dependent Ubiquitylation In Vitro.
Marc A Jarvis, Nicholas G Brown, Edmond R Watson, Ryan VanderLinden, Brenda A Schulman

Methods Mol Biol· May 2016

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Multiple Weak Linear Motifs Enhance Recruitment and Processivity in SPOP-Mediated Substrate Ubiquitination.
Wendy K Pierce, Christy R Grace, Jihun Lee, Amanda Nourse, Melissa R Marzahn, Edmond R Watson

J Mol Biol· March 2016

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RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex.
Nicholas G Brown, Ryan VanderLinden, Edmond R Watson, Renping Qiao, Christy R R Grace

Proc Natl Acad Sci U S A· April 2015

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Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly.
Nicholas G Brown, Edmond R Watson, Florian Weissmann, Marc A Jarvis, Ryan VanderLinden

Mol Cell· October 2014

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SPOP promotes tumorigenesis by acting as a key regulatory hub in kidney cancer.
Guoqiang Li, Weimin Ci, Subhradip Karmakar, Ke Chen, Ruby Dhar, Edmond R Watson

Cancer Cell· April 2014

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Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.
Jeremiah J Frye, Nicholas G Brown, Georg Petzold, Edmond R Watson, Christy R R Grace

Nat Struct Mol Biol· July 2013

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Complex interactions of Tyrp1 in the eye.
Hong Lu, Liyuan Li, Edmond R Watson, Robert W Williams, Eldon E Geisert

Mol Vis· January 2012

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