Publications by authors named "Barbara Cacciari"

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Chemical and biological versatility of pyrazolo[3,4-]pyrimidines: one scaffold, multiple modes of action.
Alessandro Trentini, Stefania Hanau, Maria Cristina Manfrinato, Barbara Cacciari

Future Med Chem· December 2023

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Synthesis and Biological Evaluation of Highly Active 7-Anilino Triazolopyrimidines as Potent Antimicrotubule Agents.
Paola Oliva, Romeo Romagnoli, Barbara Cacciari, Stefano Manfredini, Chiara Padroni

Pharmaceutics· June 2022

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Thio-substituted derivatives of 4-amino-pyrazolo[3,4-d]pyrimidine-6-thiol as antiproliferative agents.
Barbara Cacciari, Romeo Romagnoli, Arianna Romani, Alessandro Trentini, Stefania Hanau

Future Med Chem· September 2021

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Synthesis and Biological Evaluation of New Antitubulin Agents Containing 2-(3',4',5'-trimethoxyanilino)-3,6-disubstituted-4,5,6,7-tetrahydrothieno[2,3-]pyridine Scaffold.
Romeo Romagnoli, Filippo Prencipe, Paola Oliva, Barbara Cacciari, Jan Balzarini

Molecules· April 2020

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Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors.
Barbara Cacciari, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi, Giampiero Spalluto

Med Chem· December 2019

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Design, synthesis, in vitro antiproliferative activity and apoptosis-inducing studies of 1-(3',4',5'-trimethoxyphenyl)-3-(2'-alkoxycarbonylindolyl)-2-propen-1-one derivatives obtained by a molecular hybridisation approach.
Delia Preti, Romeo Romagnoli, Riccardo Rondanin, Barbara Cacciari, Ernest Hamel

J Enzyme Inhib Med Chem· December 2018

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A2A Adenosine Receptor Antagonists as Therapeutic Candidates: Are They Still an Interesting Challenge?
Barbara Cacciari, Giampiero Spalluto, Stephanie Federico

Mini Rev Med Chem· July 2018

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Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines and Structurally Simplified Analogs. Chemistry and SAR Profile as Adenosine Receptor Antagonists.
Sara Redenti, Antonella Ciancetta, Giorgia Pastorin, Barbara Cacciari, Stefano Moro

Curr Top Med Chem· February 2017

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The Influence of the 1-(3-Trifluoromethyl-Benzyl)-1H-Pyrazole-4-yl Moiety on the Adenosine Receptors Affinity Profile of Pyrazolo[4,3-e][1,2,4]Triazolo[1,5-c]Pyrimidine Derivatives.
Stephanie Federico, Sara Redenti, Mattia Sturlese, Antonella Ciancetta, Sonja Kachler, Barbara Cacciari

PLoS One· June 2016

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5,7-Disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazines as pharmacological tools to explore the antagonist selectivity profiles toward adenosine receptors.
Stephanie Federico, Antonella Ciancetta, Nicola Porta, Sara Redenti, Giorgia Pastorin, Barbara Cacciari

Eur J Med Chem· January 2016

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8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.
Diego Dal Ben, Michela Buccioni, Catia Lambertucci, Ajiroghene Thomas, Karl-Norbert Klotz, Barbara Cacciari

Eur J Med Chem· September 2014

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Scaffold decoration at positions 5 and 8 of 1,2,4-triazolo[1,5-c]pyrimidines to explore the antagonist profiling on adenosine receptors: a preliminary structure-activity relationship study.
Stephanie Federico, Antonella Ciancetta, Nicola Porta, Sara Redenti, Giorgia Pastorin, Barbara Cacciari

J Med Chem· July 2014

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Revisiting a receptor-based pharmacophore hypothesis for human A(2A) adenosine receptor antagonists.
Magdalena Bacilieri, Antonella Ciancetta, Silvia Paoletta, Stephanie Federico, Sandro Cosconati, Barbara Cacciari

J Chem Inf Model· July 2013

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Exploring the directionality of 5-substitutions in a new series of 5-alkylaminopyrazolo[4,3-e]1,2,4-triazolo[1,5-c]pyrimidine as a strategy to design novel human a(3) adenosine receptor antagonists.
Stephanie Federico, Antonella Ciancetta, Davide Sabbadin, Silvia Paoletta, Giorgia Pastorin, Barbara Cacciari

J Med Chem· November 2012

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A novel conjugated agent between dopamine and an A2A adenosine receptor antagonist as a potential anti-Parkinson multitarget approach.
Alessandro Dalpiaz, Barbara Cacciari, Chiara Beatrice Vicentini, Fabrizio Bortolotti, Giampiero Spalluto

Mol Pharm· March 2012

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Synthesis and biological evaluation of a new series of 1,2,4-triazolo[1,5-a]-1,3,5-triazines as human A(2A) adenosine receptor antagonists with improved water solubility.
Stephanie Federico, Silvia Paoletta, Siew Lee Cheong, Giorgia Pastorin, Barbara Cacciari

J Med Chem· February 2011

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Solid lipid microparticles for the stability enhancement of a dopamine prodrug.
Alessandro Dalpiaz, Barbara Cacciari, Matteo Mezzena, Mariangela Strada, Santo Scalia

J Pharm Sci· November 2010

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Synthesis and pharmacological characterization of a new series of 5,7-disubstituted-[1,2,4]triazolo[1,5-a][1,3,5]triazine derivatives as adenosine receptor antagonists: A preliminary inspection of ligand-receptor recognition process.
Giorgia Pastorin, Stephanie Federico, Silvia Paoletta, Marta Corradino, Francesca Cateni, Barbara Cacciari

Bioorg Med Chem· April 2010

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The significance of 2-furyl ring substitution with a 2-(para-substituted) aryl group in a new series of pyrazolo-triazolo-pyrimidines as potent and highly selective hA(3) adenosine receptors antagonists: new insights into structure-affinity relationship and receptor-antagonist recognition.
Siew Lee Cheong, Anna Dolzhenko, Sonja Kachler, Silvia Paoletta, Stephanie Federico, Barbara Cacciari

J Med Chem· April 2010

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Exploring potency and selectivity receptor antagonist profiles using a multilabel classification approach: the human adenosine receptors as a key study.
Lisa Michielan, Federico Stephanie, Lothar Terfloth, Dimitar Hristozov, Barbara Cacciari

J Chem Inf Model· December 2009

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6-Amino-2-mercapto-3H-pyrimidin-4-one derivatives as new candidates for the antagonism at the P2Y12 receptors.
Pamela Crepaldi, Barbara Cacciari, Maria-Cruz Bonache, Giampiero Spalluto, Katia Varani

Bioorg Med Chem· July 2009

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Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A(2A) and A(3) receptor pyrazolo-triazolo-pyrimidine antagonists binding sites.
Lisa Michielan, Chiara Bolcato, Stephanie Federico, Barbara Cacciari, Magdalena Bacilieri

Bioorg Med Chem· July 2009

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Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: Effect of the N-5 bond type on the affinity and selectivity at the four adenosine receptor subtypes.
Chiara Bolcato, Claudia Cusan, Giorgia Pastorin, Giampiero Spalluto, Barbara Cacciari

Purinergic Signal· March 2008

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Linear and nonlinear 3D-QSAR approaches in tandem with ligand-based homology modeling as a computational strategy to depict the pyrazolo-triazolo-pyrimidine antagonists binding site of the human adenosine A2A receptor.
Lisa Michielan, Magdalena Bacilieri, Andrea Schiesaro, Chiara Bolcato, Giorgia Pastorin, Barbara Cacciari

J Chem Inf Model· February 2008

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Pyrazolo-triazolo-pyrimidines as adenosine receptor antagonists: A complete structure-activity profile.
Barbara Cacciari, Chiara Bolcato, Giampiero Spalluto, Karl-Norbet Klotz, Magdalena Bacilieri

Purinergic Signal· June 2007

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