Publications by authors named "Sandro Cosconati"

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Cigarette smoke destabilizes G-quadruplex structures and antagonizes G4-ligand effects in macrophages.
Davida Mirra, Erica Salvati, Renata Esposito, Giuseppe Spaziano, Francesca Panico, Sandro Cosconati

Sci Rep· December 2025

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Identification of isoxazole-based TRPA1 inhibitors with analgesic effects in vivo.
Valentina Albanese, Matilde Marini, Martina Tesi, Lorenzo Landini, Elisa Bellantoni, Sandro Cosconati

Eur J Med Chem· September 2025

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2-(Phenylamino)-7,8-dihydroquinazolin-5(6H)-one, a promising scaffold for MAO-B inhibitors with potential GSK3β targeting.
Maria Luisa Di Paolo, Silvia Salerno, Giulia Nordio, Francesco Piazzola, Stefania Sarno, Sandro Cosconati

Eur J Med Chem· July 2025

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Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of .
Carla Di Chio, Josè Starvaggi, Santo Previti, Fabiola De Luca, Benito Natale, Sandro Cosconati

Pharmaceuticals (Basel)· June 2025

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Identification of constrained peptidomimetics carrying a Michael acceptor warhead as antitrypanosomal agents.
Santo Previti, Elsa Calcaterra, Carla Di Chio, Benito Natale, Muhammad Waqas, Sandro Cosconati

Eur J Med Chem· April 2025

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From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment.
Alessandra Del Bene, Antonia D'Aniello, Salvatore Mottola, Vincenzo Mazzarella, Roberto Cutolo, Sandro Cosconati

RSC Med Chem· April 2025

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Trimethylamine N-Oxide (TMAO) Acts as Inhibitor of Endothelial Nitric Oxide Synthase (eNOS) and Hampers NO Production and Acetylcholine-Mediated Vasorelaxation in Rat Aortas.
Alma Martelli, Federico Abate, Michele Roggia, Giada Benedetti, Eugenio Caradonna, Sandro Cosconati

Antioxidants (Basel)· April 2025

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Sustainable Ultrasound-Assisted Solid-Phase peptide synthesis (SUS-SPPS): Less Waste, more efficiency.
Salvatore Mottola, Alessandra Del Bene, Vincenzo Mazzarella, Roberto Cutolo, Ida Boccino, Sandro Cosconati

Ultrason Sonochem· March 2025

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Unveiling the role of poly(vinyl alcohol) in the production of mucus-penetrating PLGA nanoparticles.
Pouria Savadi, Andrea Casale, Michele Roggia, Gemma Conte, M Victoria Lozano, Sandro Cosconati

Int J Pharm· March 2025

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Discovery of -substituted-2-oxoindolin benzoylhydrazines as c-MET/SMO modulators in EGFRi-resistant non-small cell lung cancer.
Stefano Tomassi, Benito Natale, Michele Roggia, Luisa Amato, Caterina De Rosa, Sandro Cosconati

RSC Med Chem· January 2025

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Discovery of the First-in-Class Dual TSPO/Carbonic Anhydrase Modulators with Promising Neurotrophic Activity.
Valeria Poggetti, Elisa Angeloni, Lorenzo Germelli, Benito Natale, Muhammad Waqas, Sandro Cosconati

ACS Chem Neurosci· January 2025

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Comprehensive structural investigation of a potent and selective CXCR4 antagonist via crosslink modification.
Anna Maria Trotta, Vincenzo Mazzarella, Michele Roggia, Antonia D'Aniello, Alessandra Del Bene, Sandro Cosconati

Eur J Med Chem· December 2024

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Discovering Dually Active Anti-cancer Compounds with a Hybrid AI-structure-based Approach.
Michele Roggia, Benito Natale, Giorgio Amendola, Nicola Grasso, Salvatore Di Maro, Sandro Cosconati

J Chem Inf Model· November 2024

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Pursuing Polypharmacology: Benzothiopyranoindoles as G-Quadruplex Stabilizers and Topoisomerase I Inhibitors for Effective Anticancer Strategies.
Silvia Salerno, Elisabetta Barresi, Michele Roggia, Benito Natale, Simona Marzano, Sandro Cosconati

ACS Med Chem Lett· November 2024

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Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites.
Anna Maria Trotta, Stefano Tomassi, Gaetana Di Maiolo, Caterina Ieranò, Cinzia Vetrei, Sandro Cosconati

Eur J Med Chem· October 2024

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Quinolinonyl Derivatives as Dual Inhibitors of the HIV-1 Integrase Catalytic Site and Integrase-RNA interactions.
Elisa Patacchini, Valentina Noemi Madia, Aurora Albano, Giuseppe Ruggieri, Antonella Messore, Sandro Cosconati

ACS Med Chem Lett· September 2024

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Identification of Dual Inhibitors Targeting Main Protease (M) and Cathepsin L as Potential Anti-SARS-CoV-2 Agents.
Santo Previti, Roberta Ettari, Elsa Calcaterra, Michele Roggia, Benito Natale, Sandro Cosconati

ACS Med Chem Lett· May 2024

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Streamlining Large Chemical Library Docking with Artificial Intelligence: the PyRMD2Dock Approach.
Michele Roggia, Benito Natale, Giorgio Amendola, Salvatore Di Maro, Sandro Cosconati

J Chem Inf Model· April 2024

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Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria.
Carla Di Chio, Josè Starvaggi, Noemi Totaro, Santo Previti, Benito Natale, Sandro Cosconati

Int J Mol Sci· April 2024

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Irreversible inhibition of TRF2 recruiting functions by a covalent cyclic peptide induces telomeric replication stress in cancer cells.
Alexander P Sobinoff, Salvatore Di Maro, Ronnie R J Low, Rosaria Benedetti, Stefano Tomassi, Sandro Cosconati

Cell Chem Biol· December 2023

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Identification of a Protein Arginine Methyltransferase 7 (PRMT7)/Protein Arginine Methyltransferase 9 (PRMT9) Inhibitor.
Alessandra Feoli, Giulia Iannelli, Alessandra Cipriano, Ciro Milite, Lei Shen, Sandro Cosconati

J Med Chem· October 2023

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A cyanine-based NIR fluorescent Vemurafenib analog to probe BRAF in cancer cells.
Elisabetta Barresi, Caterina Baldanzi, Marta Roncetti, Michele Roggia, Emma Baglini, Sandro Cosconati

Eur J Med Chem· August 2023

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Ultrasound-assisted Peptide Nucleic Acids synthesis (US-PNAS).
Alessandra Del Bene, Antonia D'Aniello, Stefano Tomassi, Francesco Merlino, Vincenzo Mazzarella, Sandro Cosconati

Ultrason Sonochem· May 2023

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Structure-based lead optimization of peptide-based vinyl methyl ketones as SARS-CoV-2 main protease inhibitors.
Santo Previti, Roberta Ettari, Elsa Calcaterra, Salvatore Di Maro, Stefan J Hammerschmidt, Sandro Cosconati

Eur J Med Chem· February 2023

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Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain.
Santo Previti, Roberta Ettari, Elsa Calcaterra, Carla Di Chio, Rahul Ravichandran, Sandro Cosconati

ACS Med Chem Lett· July 2022

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