Publications by authors named "Barry Finzel"

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Reengineering of Circularly Permuted Caspase-2 to Enhance Enzyme Stability and Enable Crystallographic Studies.
Jessica L Fuller, Ke Shi, Steffen Pockes, Barry C Finzel, Karen H Ashe

ACS Chem Biol· April 2025

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Combinatorial synthesis of a hyaluronan based polysaccharide library for enhanced CD44 binding.
Kunli Liu, William M McCue, Chia-Wei Yang, Barry C Finzel, Xuefei Huang

Carbohydr Polym· January 2023

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Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.
Merlin Bresinsky, Jessica M Strasser, Alexander Hubmann, Bernadette Vallaster, William M McCue, Barry C Finzel

Arch Pharm (Weinheim)· September 2022

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Structural Characterization of the Human Cytosolic Malate Dehydrogenase I.
William M McCue, Barry C Finzel

ACS Omega· January 2022

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Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.
Merlin Bresinsky, Jessica M Strasser, Bernadette Vallaster, Peng Liu, William M McCue, Barry C Finzel

ACS Pharmacol Transl Sci· January 2022

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Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Rachit M Shah, Cristina Peterson, Alexander Strom, Maxwell Dillenburg, Barry Finzel

ACS Chem Neurosci· October 2019

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Structure and Functional Characterization of Human Histidine Triad Nucleotide-Binding Protein 1 Mutations Associated with Inherited Axonal Neuropathy with Neuromyotonia.
Rachit M Shah, Kimberly M Maize, Harrison T West, Alexander M Strom, Barry C Finzel

J Mol Biol· August 2018

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A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Kimberly M Maize, Rachit Shah, Alex Strom, Sidath Kumarapperuma, Andrew Zhou, Barry C Finzel

Mol Pharm· November 2017

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Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.
Rachit Shah, Tsui-Fen Chou, Kimberly M Maize, Alexander Strom, Barry C Finzel

Biochem Biophys Res Commun· September 2017

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Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
Feng Liu, Surendra Dawadi, Kimberly M Maize, Ran Dai, Sae Woong Park, Barry C Finzel

J Med Chem· July 2017

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Caught before Released: Structural Mapping of the Reaction Trajectory for the Sofosbuvir Activating Enzyme, Human Histidine Triad Nucleotide Binding Protein 1 (hHint1).
Rachit Shah, Kimberly M Maize, Xin Zhou, Barry C Finzel, Carston R Wagner

Biochemistry· July 2017

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Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.
Carter G Eiden, Kimberly M Maize, Barry C Finzel, John D Lipscomb, Courtney C Aldrich

J Am Chem Soc· May 2017

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Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
Rachit Shah, Alexander Strom, Andrew Zhou, Kimberly M Maize, Barry C Finzel

ACS Med Chem Lett· August 2016

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Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Kimberly M Maize, Elbek K Kurbanov, Rodney L Johnson, Elizabeth Ambrose Amin, Barry C Finzel

FEBS Lett· December 2015

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Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
Elbek K Kurbanov, Ting-Lan Chiu, Jonathan Solberg, Subhashree Francis, Kimberly M Maize, Barry C Finzel

J Med Chem· November 2015

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Targeting Mycobacterium tuberculosis Biotin Protein Ligase (MtBPL) with Nucleoside-Based Bisubstrate Adenylation Inhibitors.
Matthew R Bockman, Alvin S Kalinda, Riccardo Petrelli, Teresa De la Mora-Rey, Divya Tiwari, Barry C Finzel

J Med Chem· September 2015

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Fragment-based exploration of binding site flexibility in Mycobacterium tuberculosis BioA.
Ran Dai, Todd W Geders, Feng Liu, Sae Woong Park, Dirk Schnappinger, Barry C Finzel

J Med Chem· July 2015

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Target-based identification of whole-cell active inhibitors of biotin biosynthesis in Mycobacterium tuberculosis.
Sae Woong Park, Dominick E Casalena, Daniel J Wilson, Ran Dai, Partha P Nag, Barry C Finzel

Chem Biol· January 2015

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Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Kimberly M Maize, Elbek K Kurbanov, Teresa De La Mora-Rey, Todd W Geders, Dong Jin Hwang, Barry C Finzel

Acta Crystallogr D Biol Crystallogr· November 2014

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High-resolution crystal structures of alternate forms of the human CD44 hyaluronan-binding domain reveal a site for protein interaction.
Li-Kai Liu, Barry Finzel

Acta Crystallogr F Struct Biol Commun· September 2014

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Inhibition of Mycobacterium tuberculosis transaminase BioA by aryl hydrazines and hydrazides.
Ran Dai, Daniel J Wilson, Todd W Geders, Courtney C Aldrich, Barry C Finzel

Chembiochem· March 2014

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Fragment-based identification of an inducible binding site on cell surface receptor CD44 for the design of protein-carbohydrate interaction inhibitors.
Li-Kai Liu, Barry C Finzel

J Med Chem· March 2014

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Searching for likeness in a database of macromolecular complexes.
Jeffrey R Van Voorst, Barry C Finzel

J Chem Inf Model· October 2013

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The structure of the TOG-like domain of Drosophila melanogaster Mast/Orbit.
Teresa De la Mora-Rey, Brian D Guenther, Barry C Finzel

Acta Crystallogr Sect F Struct Biol Cryst Commun· July 2013

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