Publications by authors named "Bart Westerman"

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Recurrent Hematological Toxicity After Second-Line Treatment in Patients with Glioblastoma: Indication of a Potential Predisposition.
Leon van Hout, Femke E L van den Elzen, Zoë de Jong, Nienke Grun, Martinus P G Broen, Bart A Westerman

Oncologist· December 2025

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Evolutionary trajectories of IDH-mutant astrocytoma identify molecular grading markers related to cell cycling.
Wies R Vallentgoed, Youri Hoogstrate, Karin A van Garderen, Levi van Hijfte, Erik van Dijk, Bart A Westerman

Nat Cancer· October 2025

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Challenges to determine synergistic drug interactions in mice.
Bart A Westerman, Yoran Broersma, Tom Wurdinger, David Noske, Peter Sminia

Nat Commun· September 2025

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Combined inactivation of MEK and mTOR can lead to synergistic cell death in glioblastoma models and associates with NF1-deficiency and a mesenchymal subtype.
Fleur M G Cornelissen, Yoran Broersma, Ravi S Narayan, Rogier Dik, Sander R Piersma, Bart A Westerman

Mol Cancer Ther· August 2025

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Severe temozolomide-induced thrombocytopenia is linked to increased healthcare utilization in glioblastoma and disproportionally impacts female patients.
Leon van Hout, Alessia D Borgo, Nienke Grun, Maaike Schuur, Martijn P G Broen, Bart A Westerman

Neurooncol Pract· August 2025

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The pan-cancer proteome atlas, a mass spectrometry-based landscape for discovering tumor biology, biomarkers, and therapeutic targets.
Jaco C Knol, Mengge Lyu, Franziska Böttger, Madalena Nunes Monteiro, Thang V Pham, Bart A Westerman

Cancer Cell· July 2025

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Evaluation of SURUS: a named entity recognition NLP system to extract knowledge from interventional study records.
Casper Peeters, Koen Vijverberg, Marianne Pouwer, Bart Westerman, Maikel Boot

BMC Med Res Methodol· July 2025

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Tumor-initiating genetics and therapy drive divergent molecular evolution in IDH-mutant gliomas.
Tamrin Chowdhury, C Mircea S Tesileanu, Emre Kocakavuk, Kevin C Johnson, Jooho Lee, Bart Westerman

bioRxiv· July 2025

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Physiologically Based Pharmacokinetic Model of Tyrosine Kinase Inhibitors to Predict Target Site Penetration, with PET-Guided Verification.
Suzanne van der Gaag, Tamara Jordens, Maqsood Yaqub, Robbin Grijseels, Daan W van Valkengoed, Bart A Westerman

CPT Pharmacometrics Syst Pharmacol· May 2025

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Utilizing Large language models to select literature for meta-analysis shows workload reduction while maintaining a similar recall level as manual curation.
Xiangming Cai, Yuanming Geng, Yiming Du, Bart Westerman, Duolao Wang

BMC Med Res Methodol· April 2025

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The translatome of glioblastoma.
Fleur M G Cornelissen, Zhaoren He, Edward Ciputra, Richard R de Haas, Ammarina Beumer-Chuwonpad, Bart A Westerman

Mol Oncol· March 2025

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Gemistocytic tumor cells programmed for glial scarring characterize T cell confinement in IDH-mutant astrocytoma.
Levi van Hijfte, Marjolein Geurts, Iris de Heer, Santoesha A Ghisai, Hayri E Balcioglu, Bart Westerman

Nat Commun· January 2025

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Oncogenic composite mutations can be predicted by co-mutations and their chromosomal location.
Asli Küçükosmanoglu, Carolien L van der Borden, Lisanne E A de Boer, Roel Verhaak, David Noske, Bart A Westerman

Mol Oncol· October 2024

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A Real-world Toxicity Atlas Shows that Adverse Events of Combination Therapies Commonly Result in Additive Interactions.
Asli Küçükosmanoglu, Silvia Scoarta, Megan Houweling, Nicoleta Spinu, Thomas Wijnands, Bart A Westerman

Clin Cancer Res· April 2024

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The Epigenetic Evolution of Glioma Is Determined by the IDH1 Mutation Status and Treatment Regimen.
Tathiane M Malta, Thais S Sabedot, Natalia S Morosini, Indrani Datta, Luciano Garofano, Bart A Westerman

Cancer Res· March 2024

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Enhanced CD1d phosphatidylserine presentation using a single-domain antibody promotes immunomodulatory CD1d-TIM-3 interactions.
Roeland Lameris, Adam Shahine, Myrthe Veth, Bart Westerman, Dale I Godfrey

J Immunother Cancer· December 2023

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Longitudinal characteristics of T2-FLAIR mismatch in IDH-mutant astrocytomas: Relation to grade, histopathology, and overall survival in the GLASS-NL cohort.
Karin A van Garderen, Wies R Vallentgoed, Anna Lavrova, Johanna M Niers, Wendy W J de Leng, Bart A Westerman

Neurooncol Adv· November 2023

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Longitudinal drug synergy assessment using convolutional neural network image-decoding of glioblastoma single-spheroid cultures.
Anna Giczewska, Krzysztof Pastuszak, Megan Houweling, Kulsoom U Abdul, Noa Faaij, Bart A Westerman

Neurooncol Adv· November 2023

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Predicting the target landscape of kinase inhibitors using 3D convolutional neural networks.
Georgi K Kanev, Yaran Zhang, Albert J Kooistra, Andreas Bender, Rob Leurs, Bart A Westerman

PLoS Comput Biol· September 2023

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Explaining Blood-Brain Barrier Permeability of Small Molecules by Integrated Analysis of Different Transport Mechanisms.
Fleur M G Cornelissen, Greta Markert, Ghislaine Deutsch, Maria Antonara, Noa Faaij, Bart A Westerman

J Med Chem· June 2023

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Screening of predicted synergistic multi-target therapies in glioblastoma identifies new treatment strategies.
Megan Houweling, Anna Giczewska, Kulsoom Abdul, Ninke Nieuwenhuis, Asli Küçükosmanoglu, Bart A Westerman

Neurooncol Adv· June 2023

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Review: A Roadmap to Use Nonstructured Data to Discover Multitarget Cancer Therapies.
Silvia Scoarta, Asli Küçükosmanoglu, Felix Bindt, Marianne Pouwer, Bart A Westerman

JCO Clin Cancer Inform· April 2023

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Detection and localization of early- and late-stage cancers using platelet RNA.
Sjors G J G In 't Veld, Mohammad Arkani, Edward Post, Mafalda Antunes-Ferreira, Silvia D'Ambrosi, Bart A Westerman

Cancer Cell· September 2022

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CXCR4 expression in glioblastoma tissue and the potential for PET imaging and treatment with [Ga]Ga-Pentixafor /[Lu]Lu-Pentixather.
Sarah M Jacobs, Pieter Wesseling, Bart de Keizer, Nelleke Tolboom, F F Tessa Ververs, Bart A Westerman

Eur J Nucl Med Mol Imaging· January 2022

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Data-driven prioritization and preclinical evaluation of therapeutic targets in glioblastoma.
Cyrillo G Brahm, U Kulsoom Abdul, Megan Houweling, Myra E van Linde, Tonny Lagerweij, Bart A Westerman

Neurooncol Adv· November 2020

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