Publications by authors named "Beat Bornhauser"

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A three-dimensional ex vivo model recapitulates in vivo features and drug resistance phenotypes in childhood acute lymphoblastic leukemia.
Magdalini Kanari, Iria Jimenez Garcia, Fabio D Steffen, Lisa A Krattiger, Charles Bataclan, Beat Bornhauser

Leukemia· December 2025

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A clinical-stage oncology compound selectively targets drug-resistant cancers.
Kaitlin Long, Debanjan Bhattacharjee, Samuel H Newman-Stonebraker, Simon Suhr, Brandon Q Mercado, Beat C Bornhauser

bioRxiv· November 2025

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Transcriptional remodeling shapes therapeutic vulnerability to necroptosis in acute lymphoblastic leukemia.
Anna Saorin, Anna Dehler, Bartimée Galvan, Fabio Steffen, Marine Ray, Beat C Bornhauser

Blood· August 2025

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Role of stem-like cells in chemotherapy resistance and relapse in pediatric T-cell acute lymphoblastic leukemia.
Julia Costea, Kerstin K Rauwolf, Pietro Zafferani, Tobias Rausch, Anna Mathioudaki, Beat Bornhauser

Nat Commun· June 2025

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IAP dependency of T-cell prolymphocytic leukemia identified by high-throughput drug screening.
Marcel Fabian Pohly, Kerstin Putzker, Sebastian Scheinost, Lena Ben Taarit, Tatjana Walther, Beat Bornhauser

Blood· May 2025

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Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12.
Selina Troester, Thomas Eder, Nadja Wukowits, Martin Piontek, Pablo Fernández-Pernas, Beat Bornhauser

Nat Commun· May 2025

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SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response.
Nurul Khalida Ibrahim, Sabine Schreek, Buesra Cinar, Anna Sophie Stasche, Su Hyun Lee, Beat Bornhauser

Cell Rep· April 2025

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gene deletions drive resistance to cytarabine in B-cell precursor acute lymphoblastic leukemia.
Britt M T Vervoort, Miriam Butler, Kari J T Grünewald, Dorette S van Ingen Schenau, Trisha M Tee, Beat C Bornhauser

Haematologica· December 2024

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A first-in-class Wiskott-Aldrich syndrome protein activator with antitumor activity in hematologic cancers.
Filippo Spriano, Giulio Sartori, Jacopo Sgrignani, Laura Barnabei, Alberto J Arribas, Beat Bornhauser

Haematologica· November 2024

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Caspase-2 kills cells with extra centrosomes.
Dario Rizzotto, Vincenza Vigorito, Patricia Rieder, Filip Gallob, Gian Mario Moretta, Beat C Bornhauser

Sci Adv· November 2024

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Proteogenomic profiling uncovers differential therapeutic vulnerabilities between and translocated B-cell acute lymphoblastic leukemia.
Lena Blumel, Flavia Bernardi, Daniel Picard, Jacob Torrejon Diaz, Vera H Jepsen, Beat Bornhauser

Haematologica· July 2024

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The IL-7R antagonist lusvertikimab reduces leukemic burden in xenograft ALL via antibody-dependent cellular phagocytosis.
Lennart Lenk, Irène Baccelli, Anna Laqua, Julia Heymann, Claas Reimer, Beat Bornhauser

Blood· June 2024

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MSC.sensor: Capturing cancer cell interactions with stroma for functional profiling.
Yun Huang, Aneta Drakul, Jasmeet Sidhu, Kerstin K Rauwolf, James Kim, Beat Bornhauser

SLAS Discov· October 2023

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Functional analysis of structural variants in single cells using Strand-seq.
Hyobin Jeong, Karen Grimes, Kerstin K Rauwolf, Peter-Martin Bruch, Tobias Rausch, Beat Bornhauser

Nat Biotechnol· June 2023

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B- and T-cell acute lymphoblastic leukemias evade chemotherapy at distinct sites in the bone marrow.
Malwine J Barz, Lena Behrmann, Danaëlle Capron, Gabriele Zuchtriegel, Fabio D Steffen, Beat Bornhauser

Haematologica· May 2023

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Molecular complete remission following combination treatment of daratumumab and venetoclax in an adolescent with relapsed mixed phenotype acute leukemia.
Martin Stanulla, Denis M Schewe, Beat Bornhauser, Jean-Pierre Bourquin, Cornelia Eckert

Ann Hematol· March 2023

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Microphysiological Drug-Testing Platform for Identifying Responses to Prodrug Treatment in Primary Leukemia.
Furkan Gökçe, Alicia Kaestli, Christian Lohasz, Martina de Geus, Hans-Michael Kaltenbach, Beat Bornhauser

Adv Healthc Mater· January 2023

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Oncogenic deubiquitination controls tyrosine kinase signaling and therapy response in acute lymphoblastic leukemia.
Qi Jin, Blanca Gutierrez Diaz, Tim Pieters, Yalu Zhou, Sonali Narang, Beat Bornhauser

Sci Adv· December 2022

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LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance.
Svenja Michalek, Thomas Goj, Anna Pia Plazzo, Blerim Marovca, Beat Bornhauser

EMBO Rep· September 2022

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Supramolecular assembly of GSK3α as a cellular response to amino acid starvation.
Laura Hinze, Sabine Schreek, Andre Zeug, Nurul Khalida Ibrahim, Beate Fehlhaber, Beat Bornhauser

Mol Cell· August 2022

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Venetoclax enhances the efficacy of therapeutic antibodies in B-cell malignancies by augmenting tumor cell phagocytosis.
Fotini Vogiatzi, Julia Heymann, Kristina Müller, Dorothee Winterberg, Aneta Drakul, Beat Bornhauser

Blood Adv· August 2022

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Combining daratumumab with CD47 blockade prolongs survival in preclinical models of pediatric T-ALL.
Kristina Müller, Fotini Vogiatzi, Dorothee Winterberg, Thies Rösner, Lennart Lenk, Beat Bornhauser

Blood· July 2022

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Pediatric T-ALL type-1 and type-2 relapses develop along distinct pathways of clonal evolution.
Paulina Richter-Pechańska, Joachim B Kunz, Tobias Rausch, Büşra Erarslan-Uysal, Beat Bornhauser

Leukemia· July 2022

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Clonal dynamics in pediatric B-cell precursor acute lymphoblastic leukemia with very early relapse.
Željko Antić, Jiangyan Yu, Beat C Bornhauser, Stefan H Lelieveld, Cedric G van der Ham

Pediatr Blood Cancer· January 2022

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High Immunoproteasome Activity and sXBP1 in Pediatric Precursor B-ALL Predicts Sensitivity towards Proteasome Inhibitors.
Lenka Besse, Andrej Besse, Marianne Kraus, Elmer Maurits, Herman S Overkleeft, Beat Bornhauser

Cells· October 2021

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