Publications by authors named "Beata Flachner"

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RuX: A Novel, Flexible, and Sensitive Mifepristone-Induced Transcriptional Regulation System.
Anne Meinzinger, Áron Zsigmond, Péter Horváth, Alexandra Kellenberger, Katalin Paréj, Beáta Flachner

Int J Cell Biol· October 2023

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Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer's Disease: From In Silico to In Vivo.
Noa Stern, Alexandra Gacs, Enikő Tátrai, Beáta Flachner, István Hajdú

Int J Mol Sci· October 2022

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Robust Recombinant Expression of Human Placental Ribonuclease Inhibitor in Insect Cells.
Beáta Flachner, Krisztina Dobi, Anett Benedek, Sándor Cseh, Zsolt Lőrincz

Biomolecules· February 2022

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Rapid Identification of Potential Drug Candidates from Multi-Million Compounds' Repositories. Combination of 2D Similarity Search with 3D Ligand/Structure Based Methods and In Vitro Screening.
Katalin Szilágyi, Beáta Flachner, István Hajdú, Mária Szaszkó, Krisztina Dobi

Molecules· September 2021

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A versatile modular vector set for optimizing protein expression among bacterial, yeast, insect and mammalian hosts.
Márk Somogyi, Tamás Szimler, Attila Baksa, Barbara M Végh, Tamás Bakos, Beáta Flachner

PLoS One· April 2020

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Design and Selection of Novel C1s Inhibitors by In Silico and In Vitro Approaches.
Katalin Szilágyi, István Hajdú, Beáta Flachner, Zsolt Lőrincz, Júlia Balczer

Molecules· October 2019

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Identification of potential glutaminyl cyclase inhibitors from lead-like libraries by in silico and in vitro fragment-based screening.
Mária Szaszkó, István Hajdú, Beáta Flachner, Krisztina Dobi, Csaba Magyar

Mol Divers· February 2017

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Structure-Based Consensus Scoring Scheme for Selecting Class A Aminergic GPCR Fragments.
Ádám A Kelemen, Róbert Kiss, György G Ferenczy, László Kovács, Beáta Flachner

J Chem Inf Model· February 2016

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Combination of Pharmacophore Matching, 2D Similarity Search, and In Vitro Biological Assays in the Selection of Potential 5-HT6 Antagonists from Large Commercial Repositories.
Krisztina Dobi, Beáta Flachner, Mária Pukáncsik, Enikő Máthé, Melinda Bognár

Chem Biol Drug Des· October 2015

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Monoclonal antibody proteomics: use of antibody mimotope displaying phages and the relevant synthetic peptides for mAb scouting.
István Hajdú, Beáta Flachner, Melinda Bognár, Barbara M Végh, Krisztina Dobi

Immunol Lett· August 2014

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Combination of 2D/3D ligand-based similarity search in rapid virtual screening from multimillion compound repositories. Selection and biological evaluation of potential PDE4 and PDE5 inhibitors.
Krisztina Dobi, István Hajdú, Beáta Flachner, Gabriella Fabó, Mária Szaszkó

Molecules· May 2014

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[Selection of a melanine concentrating hormone receptor-1 (MCHR1) antagonists' focused library and its biological screening with AequoScreen].
Beáta Flachner, István Hajdú, Krisztina Dobi, Zsolt Lorincz, Sándor Cseh

Acta Pharm Hung· January 2014

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A chemocentric approach to the identification of cancer targets.
Beáta Flachner, Zsolt Lörincz, Angelo Carotti, Orazio Nicolotti, Praveena Kuchipudi

PLoS One· September 2012

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Inhibition of c-Met with the specific small molecule tyrosine kinase inhibitor SU11274 decreases growth and metastasis formation of experimental human melanoma.
István Kenessey, Magdolna Keszthelyi, Z Krámer, Judit Berta, Attila Adám, Beáta Flachner

Curr Cancer Drug Targets· May 2010

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Thermodynamic analysis of substrate induced domain closure of 3-phosphoglycerate kinase.
Andrea Varga, Judit Szabó, Beáta Flachner, Zoltán Gugolya, Ferenc Vonderviszt

FEBS Lett· November 2009

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Communication between the nucleotide site and the main molecular hinge of 3-phosphoglycerate kinase.
Judit Szabó, Andrea Varga, Beáta Flachner, Peter V Konarev, Dmitri I Svergun

Biochemistry· July 2008

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Role of side-chains in the operation of the main molecular hinge of 3-phosphoglycerate kinase.
Judit Szabó, Andrea Varga, Beáta Flachner, Peter V Konarev, Dmitri I Svergun

FEBS Lett· April 2008

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Interaction of human 3-phosphoglycerate kinase with L-ADP, the mirror image of D-ADP.
Andrea Varga, Judit Szabó, Beáta Flachner, Béatrice Roy, Peter Konarev

Biochem Biophys Res Commun· February 2008

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Substrate-induced double sided H-bond network as a means of domain closure in 3-phosphoglycerate kinase.
Andrea Varga, Beáta Flachner, Peter Konarev, Eva Gráczer, Judit Szabó

FEBS Lett· May 2006

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Substrate-assisted movement of the catalytic Lys 215 during domain closure: site-directed mutagenesis studies of human 3-phosphoglycerate kinase.
Beáta Flachner, Andrea Varga, Judit Szabó, László Barna, István Hajdú

Biochemistry· December 2005

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Correlation between conformational stability of the ternary enzyme-substrate complex and domain closure of 3-phosphoglycerate kinase.
Andrea Varga, Beáta Flachner, Eva Gráczer, Szabolcs Osváth, Andrea N Szilágyi

FEBS J· April 2005

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Role of phosphate chain mobility of MgATP in completing the 3-phosphoglycerate kinase catalytic site: binding, kinetic, and crystallographic studies with ATP and MgATP.
Beáta Flachner, Zoltán Kovári, Andrea Varga, Zoltán Gugolya, Ferenc Vonderviszt

Biochemistry· March 2004

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Crystallographic and thiol-reactivity studies on the complex of pig muscle phosphoglycerate kinase with ATP analogues: correlation between nucleotide binding mode and helix flexibility.
Zoltán Kovári, Beáta Flachner, Gábor Náray-Szabó, Mária Vas

Biochemistry· July 2002

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Nucleotide binding to pig muscle 3-phosphoglycerate kinase in the crystal and in solution: relationship between substrate antagonism and interdomain communication.
Angelo Merli, Andrea N Szilágyi, Beáta Flachner, Gian Luigi Rossi, Mária Vas

Biochemistry· January 2002

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