Publications by authors named "Beau Webber"

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Leukemia escapes immunity by imposing a type 1 regulatory program on neoantigen-specific CD4+ T cells.
Hrishi Venkatesh, Enoc Granados Centeno, Qianyun Luo, Miriam Arroyo, Lynn Heltemes-Harris, Beau R Webber

Blood· December 2025

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Installation of dominant-negative mutations in and via base editing in primary T cells.
Bryce J Wick, Mitchell G Kluesner, Nicholas J Slipek, Joseph G Skeate, Ethan M Niemeyer, Beau R Webber

Mol Ther Oncol· December 2025

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Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks.
Scott L Baughan, Timothy Folsom, Matt Johnson, Joshua Kreuger, Beau Webber

Front Immunol· December 2025

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Bcl-2 protein Noxa is required for metabolic reprogramming to glutamine dependence and for apoptosis in stimulated human CD8 T cells.
Tingyuan Yang, Himani Sharma, Jenna M Benson, William J Valente, Rebecca LaRue, Beau Webber

bioRxiv· December 2025

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A pig with functional human immunity.
Christopher K Tuggle, Crystal L Loving, Beau R Webber

Nat Biomed Eng· October 2025

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Clinical manufacture of CRISPR/Cas9-based cytokine-induced SH2 protein knock-out tumor-infiltrating lymphocytes for gastrointestinal cancers.
Matthew J Johnson, Darin Sumstad, Timothy D Folsom, Nicholas J Slipek, Anthony P DeFeo, Beau R Webber

Cytotherapy· October 2025

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Mathematical model of CISH knockout predicts increased efficacy in tumor-infiltrating lymphocyte activation with synergistic gene editing.
Nikolaos Memmos, Kamran Kaveh, Beau R Webber, Branden S Moriarity, David J Odde

bioRxiv· October 2025

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Installation of Dominant-Negative Mutations in and via Base Editing in Primary T Cells.
Bryce J Wick, Mitchell G Kluesner, Nicholas J Slipek, Joseph G Skeate, Ethan M Niemeyer, Beau R Webber

bioRxiv· September 2025

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CRISPR-engineered T-cell therapies: some clarifications needed - Authors' reply.
Beau R Webber, Branden S Moriarity, Timothy K Starr, David H McKenna, Emil Lou

Lancet Oncol· August 2025

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A Singular Base Editing Platform for Polyfunctional Multiplex Engineering of Immune Cells.
Joseph G Skeate, Nicholas J Slipek, Walker S Lahr, Shambojit Roy, Bryce J Wick, Beau R Webber

bioRxiv· July 2025

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Targeting the intracellular immune checkpoint CISH with CRISPR-Cas9-edited T cells in patients with metastatic colorectal cancer: a first-in-human, single-centre, phase 1 trial.
Emil Lou, Modassir S Choudhry, Timothy K Starr, Timothy D Folsom, Jason Bell, Beau R Webber

Lancet Oncol· May 2025

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Precision enhancement of CAR-NK cells through non-viral engineering and highly multiplexed base editing.
Minjing Wang, Joshua B Krueger, Alexandria K Gilkey, Erin M Stelljes, Mitchell G Kluesner, Beau R Webber

J Immunother Cancer· May 2025

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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates.
Matthew J Johnson, Anthony P DeFeo, Nicholas J Slipek, Timothy D Folsom, Tom Henley, Beau R Webber

J Vis Exp· May 2025

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CAR-T cell targeting three receptors on autoreactive B cells for systemic lupus erythematosus therapy.
Vinayak Uppin, Hunter Gibbons, Marissa Troje, Daniel Feinberg, Beau R Webber

J Autoimmun· February 2025

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Ablation of FAS confers allogeneic CD3 CAR T cells with resistance to rejection by T cells and natural killer cells.
Silvia Menegatti, Sheila Lopez-Cobo, Aurelien Sutra Del Galy, Jaime Fuentealba, Lisseth Silva, Beau R Webber

Nat Biomed Eng· December 2024

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Leukemia escapes immunity by imposing a Type-1 regulatory program on neoantigen-specific CD4+ T cells.
Hrishi Venkatesh, Lynn Heltemes-Harris, Miriam Arroyo, Todd P Knutson, Yinjie Qiu, Beau R Webber

bioRxiv· December 2024

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Engineering memory T cells as a platform for long-term enzyme replacement therapy in lysosomal storage disorders.
Evan W Kleinboehl, Kanut Laoharawee, Jacob D Jensen, Joseph J Peterson, Nicholas J Slipek, Beau R Webber

Mol Ther· November 2024

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Efficient multiplex non-viral engineering and expansion of polyclonal γδ CAR-T cells for immunotherapy.
Jacob Bridge, Matthew J Johnson, Jihyun Kim, Sophia Wenthe, Joshua Krueger, Beau R Webber

bioRxiv· October 2024

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Evolution of the clinical-stage hyperactive TcBuster transposase as a platform for robust non-viral production of adoptive cellular therapies.
Joseph G Skeate, Emily J Pomeroy, Nicholas J Slipek, Bryan J Jones, Bryce J Wick, Beau R Webber

Mol Ther· June 2024

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Development and testing of a versatile genome editing application reporter (V-GEAR) system.
Evan W Kleinboehl, Kanut Laoharawee, Walker S Lahr, Jacob D Jensen, Joseph J Peterson, Beau R Webber

Mol Ther Methods Clin Dev· June 2024

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Advancing gene targeting for primary immune deficiencies: Adenine base editing of the human IL2RG locus for correction of SCID-X1.
R Scott McIvor, Ella J Eaton, Beau R Webber, Branden S Moriarity

Mol Ther· June 2024

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Engineering Memory T Cells as a platform for Long-Term Enzyme Replacement Therapy in Lysosomal Storage Disorders.
Kanut Laoharawee, Evan W Kleinboehl, Jacob D Jensen, Joseph J Peterson, Nicholas J Slipek, Beau R Webber

bioRxiv· April 2024

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Precision Enhancement of CAR-NK Cells through Non-Viral Engineering and Highly Multiplexed Base Editing.
Minjing Wang, Joshua B Krueger, Alexandria K Gilkey, Erin M Stelljes, Mitchell G Kluesner, Beau R Webber

bioRxiv· March 2024

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Author Correction: Date fruit melanin is primarily based on (-)-epicatechin proanthocyanidin oligomers.
Muneeba Zubair Alam, Clinton Emeka Okonkwo, João P Cachaneski-Lopes, Carlos F O Graeff, Augusto Batagin-Neto, J Beau W Webber

Sci Rep· March 2024

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Date fruit melanin is primarily based on (-)-epicatechin proanthocyanidin oligomers.
Muneeba Zubair Alam, Clinton Emeka Okonkwo, João P Cachaneski-Lopes, Carlos F O Graeff, Augusto Batagin-Neto, J Beau W Webber

Sci Rep· February 2024

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