Publications by authors named "Benjamin Ayida"

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Douglas E Murphy, Chinh V Tran, Lian-Sheng Li, Jingjing Zhao, Benjamin K Ayida

Bioorg Med Chem Lett· November 2009

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Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Zhongxiang Sun, Benjamin K Ayida, Stephen E Webber, Yuefen Zhou

Bioorg Med Chem Lett· September 2008

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Sun Hee Kim, Martin T Tran, Frank Ruebsam, Alan X Xiang, Benjamin Ayida

Bioorg Med Chem Lett· July 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Lian-Sheng Li, Yuefen Zhou, Douglas E Murphy, Nebojsa Stankovic, Jingjing Zhao, Benjamin Ayida

Bioorg Med Chem Lett· June 2008

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Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
Yuefen Zhou, Vlad E Gregor, Benjamin K Ayida, Geoffrey C Winters, Zhongxiang Sun

Bioorg Med Chem Lett· March 2007

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Structure-guided discovery of novel aminoglycoside mimetics as antibacterial translation inhibitors.
Yuefen Zhou, Vlad E Gregor, Zhongxiang Sun, Benjamin K Ayida, Geoffrey C Winters

Antimicrob Agents Chemother· December 2005

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Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics.
Benjamin K Ayida, Klaus B Simonsen, Dionisios Vourloumis, Thomas Hermann

Bioorg Med Chem Lett· May 2005

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Aminoglycoside-hybrid ligands targeting the ribosomal decoding site.
Dionisios Vourloumis, Geoffrey C Winters, Klaus B Simonsen, Masayuki Takahashi, Benjamin K Ayida

Chembiochem· January 2005

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Monitoring molecular recognition of the ribosomal decoding site.
Sarah Shandrick, Qiang Zhao, Qing Han, Benjamin K Ayida, Masayuki Takahashi

Angew Chem Int Ed Engl· June 2004

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Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome.
Sofia Barluenga, Klaus B Simonsen, Ethel S Littlefield, Benjamin K Ayida, Dionisios Vourloumis

Bioorg Med Chem Lett· February 2004

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Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site.
Dionisios Vourloumis, Geoffrey C Winters, Masayuki Takahashi, Klaus B Simonsen, Benjamin K Ayida

Chembiochem· September 2003

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Piperidine glycosides targeting the ribosomal decoding site.
Klaus B Simonsen, Benjamin K Ayida, Dionisios Vourloumis, Geoffrey C Winters, Masayuki Takahashi

Chembiochem· September 2003

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Novel 2,5-dideoxystreptamine derivatives targeting the ribosomal decoding site RNA.
Dionisios Vourloumis, Masayuki Takahashi, Geoffrey C Winters, Klaus B Simonsen, Benjamin K Ayida

Bioorg Med Chem Lett· December 2002

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Novel paromamine derivatives exploring shallow-groove recognition of ribosomal-decoding-site RNA.
Klaus B Simonsen, Benjamin K Ayida, Dionisios Vourloumis, Masayuki Takahashi, Geoffrey C Winters

Chembiochem· December 2002

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