Publications by authors named "Stephen E Webber"

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Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
Siegfried H Reich, Paul A Sprengeler, Gary G Chiang, James R Appleman, Joan Chen, Stephen E Webber

J Med Chem· April 2018

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Illuminator: increasing synergies between medicinal and computational chemists.
Alberto Gobbi, Matthew Lardy, Sun Hee Kim, Frank Ruebsam, Martin Tran, Stephen E Webber

In Silico Biol· July 2012

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5,5'- and 6,6'-dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
David A Ellis, Julie K Blazel, Chinh V Tran, Frank Ruebsam, Douglas E Murphy, Stephen E Webber

Bioorg Med Chem Lett· November 2009

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Douglas E Murphy, Chinh V Tran, Lian-Sheng Li, Jingjing Zhao, Stephen E Webber

Bioorg Med Chem Lett· November 2009

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Transcription inactivation through local refolding of the RNA polymerase structure.
Georgiy A Belogurov, Marina N Vassylyeva, Anastasiya Sevostyanova, James R Appleman, Alan X Xiang, Stephen E Webber

Nature· January 2009

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5,6-Dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Chinh V Tran, Lian-Sheng Li, Sun Hee Kim, Alan X Xiang, Stephen E Webber

Bioorg Med Chem Lett· January 2009

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5: Exploration of pyridazinones containing 6-amino-substituents.
Peter S Dragovich, Julie K Blazel, David A Ellis, Qing Han, Ruhi Kamran, Stephen E Webber

Bioorg Med Chem Lett· October 2008

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Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Zhongxiang Sun, Benjamin K Ayida, Stephen E Webber, Yuefen Zhou

Bioorg Med Chem Lett· September 2008

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4-(1,1-Dioxo-1,4-dihydro-1lambda6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase.
David A Ellis, Julie K Blazel, Stephen E Webber, Chinh V Tran, Peter S Dragovich

Bioorg Med Chem Lett· August 2008

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase.
Sun Hee Kim, Martin T Tran, Frank Ruebsam, Alan X Xiang, Benjamin Ayida, Stephen E Webber

Bioorg Med Chem Lett· July 2008

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Antibacterial activity in serum of the 3,5-diamino-piperidine translation inhibitors.
Yuefen Zhou, Chun Chow, Douglas E Murphy, Zhongxiang Sun, Thomas Bertolini, Stephen E Webber

Bioorg Med Chem Lett· June 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones: Part 4. Optimization of DMPK properties.
Maria V Sergeeva, Yuefen Zhou, Darian M Bartkowski, Thomas G Nolan, Daniel A Norris, Stephen E Webber

Bioorg Med Chem Lett· June 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments.
Lian-Sheng Li, Yuefen Zhou, Douglas E Murphy, Nebojsa Stankovic, Jingjing Zhao, Stephen E Webber

Bioorg Med Chem Lett· June 2008

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Pyrrolo[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase.
Frank Ruebsam, Stephen E Webber, Martin T Tran, Chinh V Tran, Douglas E Murphy

Bioorg Med Chem Lett· June 2008

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Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine.
Alan X Xiang, Stephen E Webber, Bradley M Kerr, Erik J Rueden, Joseph R Lennox

Nucleosides Nucleotides Nucleic Acids· February 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2- and 6-pyridazinone substituents.
Yuefen Zhou, Lian-Sheng Li, Peter S Dragovich, Douglas E Murphy, Chinh V Tran, Stephen E Webber

Bioorg Med Chem Lett· February 2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: exploration of 7'-substitution of benzothiadiazine.
Yuefen Zhou, Stephen E Webber, Douglas E Murphy, Lian-Sheng Li, Peter S Dragovich

Bioorg Med Chem Lett· February 2008

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Syntheses of novel myxopyronin B analogs as potential inhibitors of bacterial RNA polymerase.
Ricardo Lira, Alan X Xiang, Thomas Doundoulakis, William T Biller, Konstantinos A Agrios, Stephen E Webber

Bioorg Med Chem Lett· December 2007

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Water-in-carbon dioxide emulsions stabilized with hydrophobic silica particles.
Stephanie S Adkins, Dhiren Gohil, Jasper L Dickson, Stephen E Webber, Keith P Johnston

Phys Chem Chem Phys· December 2007

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Photophysics of water soluble perylene diimides in surfactant solutions.
Tingji Tang, Kalina Peneva, Klaus Müllen, Stephen E Webber

J Phys Chem A· October 2007

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Energy transfer in molecular layer-by-layer films of water-soluble perylene diimides.
Tingji Tang, Andreas Herrmann, Kalina Peneva, Klaus Müllen, Stephen E Webber

Langmuir· April 2007

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Synthesis and SAR of 3,5-diamino-piperidine derivatives: novel antibacterial translation inhibitors as aminoglycoside mimetics.
Yuefen Zhou, Vlad E Gregor, Benjamin K Ayida, Geoffrey C Winters, Zhongxiang Sun, Stephen E Webber

Bioorg Med Chem Lett· March 2007

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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Huw D Thomas, Christopher R Calabrese, Michael A Batey, Stacie Canan, Zdenek Hostomsky, Stephen E Webber

Mol Cancer Ther· March 2007

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Water-soluble perylene diimides: Solution photophysics and layer-by-layer incorporation into polyelectrolyte films.
Tingji Tang, Jianqiang Qu, Klaus Müllen, Stephen E Webber

Langmuir· August 2006

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Long-ranged electrostatic repulsion and crystallization of emulsion droplets in an ultralow dielectric medium supercritical carbon dioxide.
Won Ryoo, Stephen E Webber, Roger T Bonnecaze, Keith P Johnston

Langmuir· January 2006

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