Publications by authors named "Zdenek Hostomsky"

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Combined gemcitabine and CHK1 inhibitor treatment induces apoptosis resistance in cancer stem cell-like cells enriched with tumor spheroids from a non-small cell lung cancer cell line.
Douglas D Fang, Joan Cao, Jitesh P Jani, Konstantinos Tsaparikos, Alessandra Blasina, Zdenek Hostomsky

Front Med· December 2013

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Therapeutic potential of poly(ADP-ribose) polymerase inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2.
Yvette Drew, Evan A Mulligan, Wan-Tse Vong, Huw D Thomas, Samra Kahn, Zdenek Hostomsky

J Natl Cancer Inst· February 2011

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Development of a functional assay for homologous recombination status in primary cultures of epithelial ovarian tumor and correlation with sensitivity to poly(ADP-ribose) polymerase inhibitors.
Asima Mukhopadhyay, Ahmed Elattar, Aiste Cerbinskaite, Sarah J Wilkinson, Yvette Drew, Zdenek Hostomsky

Clin Cancer Res· April 2010

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Inhibition of poly(ADP-ribose) polymerase-1 enhances temozolomide and topotecan activity against childhood neuroblastoma.
Rachel A Daniel, Agata L Rozanska, Huw D Thomas, Evan A Mulligan, Yvette Drew, Zdenek Hostomsky

Clin Cancer Res· February 2009

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Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial.
Huw D Thomas, Christopher R Calabrese, Michael A Batey, Stacie Canan, Zdenek Hostomsky

Mol Cancer Ther· March 2007

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Design, synthesis, and evaluation of 3,4-dihydro-2H-[1,4]diazepino[6,7,1-hi]indol-1-ones as inhibitors of poly(ADP-ribose) polymerase.
Jayashree G Tikhe, Stephen E Webber, Zdenek Hostomsky, Karen A Maegley, Anne Ekkers

J Med Chem· October 2004

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Potentiation of cytotoxic drug activity in human tumour cell lines, by amine-substituted 2-arylbenzimidazole-4-carboxamide PARP-1 inhibitors.
Alex W White, Nicola J Curtin, Brian W Eastman, Bernard T Golding, Zdenek Hostomsky

Bioorg Med Chem Lett· May 2004

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Novel poly(ADP-ribose) polymerase-1 inhibitor, AG14361, restores sensitivity to temozolomide in mismatch repair-deficient cells.
Nicola J Curtin, Lan-Zhen Wang, Anthie Yiakouvaki, Suzanne Kyle, Christine A Arris, Zdenek Hostomsky

Clin Cancer Res· February 2004

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Anticancer chemosensitization and radiosensitization by the novel poly(ADP-ribose) polymerase-1 inhibitor AG14361.
Christopher R Calabrese, Robert Almassy, Stephanie Barton, Michael A Batey, A Hilary Calvert, Zdenek Hostomsky

J Natl Cancer Inst· January 2004

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Identification of potent nontoxic poly(ADP-Ribose) polymerase-1 inhibitors: chemopotentiation and pharmacological studies.
Christopher R Calabrese, Michael A Batey, Huw D Thomas, Barbara W Durkacz, Lan-Zhen Wang, Zdenek Hostomsky

Clin Cancer Res· July 2003

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Tricyclic benzimidazoles as potent poly(ADP-ribose) polymerase-1 inhibitors.
Donald J Skalitzky, Joseph T Marakovits, Karen A Maegley, Anne Ekker, Xiao-Hong Yu, Zdenek Hostomsky

J Med Chem· January 2003

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Novel tricyclic poly(ADP-ribose) polymerase-1 inhibitors with potent anticancer chemopotentiating activity: design, synthesis, and X-ray cocrystal structure.
Stacie S Canan Koch, Lars H Thoresen, Jayashree G Tikhe, Karen A Maegley, Robert J Almassy, Zdenek Hostomsky

J Med Chem· November 2002

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