Publications by authors named "Benjamin D Stevens"

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Pharmacokinetics and metabolism studies on the glucagon-like peptide-1 (GLP-1)-derived metabolite GLP-1(9-36)amide in male Beagle dogs.
Heather Eng, Raman Sharma, Thomas S McDonald, Margaret S Landis, Benjamin D Stevens

Xenobiotica· September 2014

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A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Whitney M Nolte, Jean-Philippe Fortin, Benjamin D Stevens, Gary E Aspnes, David A Griffith

Nat Chem Biol· August 2014

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Identification of a novel conformationally constrained glucagon receptor antagonist.
Esther C Y Lee, Meihua Tu, Benjamin D Stevens, Jianwei Bian, Gary Aspnes

Bioorg Med Chem Lett· February 2014

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In vitro metabolism of the glucagon-like peptide-1 (GLP-1)-derived metabolites GLP-1(9-36)amide and GLP-1(28-36)amide in mouse and human hepatocytes.
Raman Sharma, Thomas S McDonald, Heather Eng, Chris Limberakis, Benjamin D Stevens

Drug Metab Dispos· December 2013

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Discovery of an intravenous hepatoselective glucokinase activator for the treatment of inpatient hyperglycemia.
Benjamin D Stevens, John Litchfield, Jeffrey A Pfefferkorn, Karen Atkinson, Christian Perreault

Bioorg Med Chem Lett· December 2013

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Demonstration of the innate electrophilicity of 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine (BETP), a small-molecule positive allosteric modulator of the glucagon-like peptide-1 receptor.
Heather Eng, Raman Sharma, Thomas S McDonald, David J Edmonds, Jean-Philippe Fortin, Benjamin D Stevens

Drug Metab Dispos· August 2013

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The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Angel Guzman-Perez, Jeffrey A Pfefferkorn, Esther C Y Lee, Benjamin D Stevens, Gary E Aspnes

Bioorg Med Chem Lett· May 2013

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Structure-based fragment screening is demonstrated to be a practical lead discovery method for a representative G-protein-coupled receptor.
Benjamin D Stevens

J Med Chem· May 2013

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Glucokinase activators.
Kevin J Filipski, Kentaro Futatsugi, Jeffrey A Pfefferkorn, Benjamin D Stevens

Pharm Pat Anal· July 2012

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Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
Jeffrey A Pfefferkorn, Angel Guzman-Perez, John Litchfield, Robert Aiello, Judith L Treadway, Benjamin D Stevens

J Med Chem· February 2012

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A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity.
Kevin J Filipski, Jianwei Bian, David C Ebner, Esther C Y Lee, Jian-Cheng Li, Benjamin D Stevens

Bioorg Med Chem Lett· January 2012

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Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors.
Vincent Mascitti, Tristan S Maurer, Ralph P Robinson, Jianwei Bian, Carine M Boustany-Kari, Benjamin D Stevens

J Med Chem· April 2011

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Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Vincent Mascitti, Benjamin D Stevens, Chulho Choi, Kim F McClure, Cristiano R W Guimarães

Bioorg Med Chem Lett· March 2011

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Strategies for expanding structural diversity available from olefin isomerization-claisen rearrangement reactions.
Benjamin D Stevens, Christopher J Bungard, Scott G Nelson

J Org Chem· August 2006

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Tandem Sakurai-aldol addition reactions as a route to structurally complex carbocycles.
Benjamin D Stevens, Scott G Nelson

J Org Chem· May 2005

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Immobilized enzymes as catalytically-active tools for nanofabrication.
Chang-Hyun Jang, Benjamin D Stevens, Paul R Carlier, Michael A Calter, William A Ducker

J Am Chem Soc· October 2002

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