Publications by authors named "Ralph P Robinson"

Claim this Profile
O
Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.
Ed J Griffen, Daren Fearon, Briana L McGovern, Lizbe Koekemoer, Blake H Balcomb, Ralph P Robinson, Matthew Robinson

bioRxiv· June 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Melissa L Boby, Daren Fearon, Matteo Ferla, Mihajlo Filep, Lizbé Koekemoer, Matthew C Robinson, Ralph P Robinson

Science· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
Ariamala Gopalsamy, Ann E Aulabaugh, Amey Barakat, Kevin C Beaumont, Shawn Cabral, Ralph P Robinson

J Med Chem· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.
Agustin Casimiro-Garcia, John I Trujillo, Felix Vajdos, Brian Juba, Mary Ellen Banker, Ralph P Robinson

J Med Chem· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Correction to Discovery of the Hemifumarate and (α-l-Alanyloxy)methyl Ether as Prodrugs of an Antirheumatic Oxindole: Prodrugs for the Enolic OH Group.
Ralph P Robinson, Lawrence A Reiter, Wayne E Barth, Anthony M Campeta, Kelvin Cooper

J Med Chem· April 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide (PF-04965842): A Selective JAK1 Clinical Candidate for the Treatment of Autoimmune Diseases.
Michael L Vazquez, Neelu Kaila, Joseph W Strohbach, John D Trzupek, Matthew F Brown, Ralph P Robinson

J Med Chem· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Covalent Enzyme Inhibition through Fluorosulfate Modification of a Noncatalytic Serine Residue.
Olugbeminiyi O Fadeyi, Lise R Hoth, Chulho Choi, Xidong Feng, Ariamala Gopalsamy, Ralph P Robinson

ACS Chem Biol· August 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis.
Olugbeminiyi Fadeyi, Mihir D Parikh, Ming Z Chen, Robert E Kyne, Alexandria P Taylor, Ralph P Robinson

Chembiochem· October 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Modern advances in heterocyclic chemistry in drug discovery.
Alexandria P Taylor, Ralph P Robinson, Yvette M Fobian, David C Blakemore, Lyn H Jones

Org Biomol Chem· July 2016

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A library approach to rapidly discover photoaffinity probes of the mRNA decapping scavenger enzyme DcpS.
Hua Xu, Erik C Hett, Ariamala Gopalsamy, Mihir D Parikh, Kieran F Geoghegan, Ralph P Robinson

Mol Biosyst· October 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
R
Rational targeting of active-site tyrosine residues using sulfonyl fluoride probes.
Erik C Hett, Hua Xu, Kieran F Geoghegan, Ariamala Gopalsamy, Robert E Kyne, Ralph P Robinson

ACS Chem Biol· April 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
2
2-Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as potent dissociated glucocorticoid receptor agonists.
Yves A Chantigny, John C Murray, Edward F Kleinman, Ralph P Robinson, Michael A Plotkin

J Med Chem· March 2015

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
F
From partial to full agonism: identification of a novel 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole as a full agonist of the human GPR119 receptor.
Kentaro Futatsugi, Vincent Mascitti, Cristiano R W Guimarães, Nao Morishita, Cuiman Cai, Ralph P Robinson

Bioorg Med Chem Lett· January 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and synthesis of diazatricyclodecane agonists of the G-protein-coupled receptor 119.
Etzer Darout, Ralph P Robinson, Kim F McClure, Matthew Corbett, Bryan Li

J Med Chem· January 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pharmacodynamic model of sodium-glucose transporter 2 (SGLT2) inhibition: implications for quantitative translational pharmacology.
Tristan S Maurer, Avijit Ghosh, Nahor Haddish-Berhane, Aarti Sawant-Basak, Carine M Boustany-Kari, Ralph P Robinson

AAPS J· December 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preclinical species and human disposition of PF-04971729, a selective inhibitor of the sodium-dependent glucose cotransporter 2 and clinical candidate for the treatment of type 2 diabetes mellitus.
Amit S Kalgutkar, Meera Tugnait, Tong Zhu, Emi Kimoto, Zhuang Miao, Ralph P Robinson

Drug Metab Dispos· September 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide.
Ralph P Robinson, Jeremy A Bartlett, Peter Bertinato, Andrew J Bessire, Judith Cosgrove

Bioorg Med Chem Lett· July 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Discovery of a clinical candidate from the structurally unique dioxa-bicyclo[3.2.1]octane class of sodium-dependent glucose cotransporter 2 inhibitors.
Vincent Mascitti, Tristan S Maurer, Ralph P Robinson, Jianwei Bian, Carine M Boustany-Kari

J Med Chem· April 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and evaluation of a 2-(2,3,6-trifluorophenyl)acetamide derivative as an agonist of the GPR119 receptor.
Vincent Mascitti, Benjamin D Stevens, Chulho Choi, Kim F McClure, Cristiano R W Guimarães, Ralph P Robinson

Bioorg Med Chem Lett· March 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Activation of the G-protein-coupled receptor 119: a conformation-based hypothesis for understanding agonist response.
Kim F McClure, Etzer Darout, Cristiano R W Guimarães, Michael P DeNinno, Vincent Mascitti, Ralph P Robinson

J Med Chem· March 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.
Amit S Kalgutkar, Vincent Mascitti, Raman Sharma, Gregory W Walker, Tim Ryder, Ralph P Robinson

Chem Res Toxicol· February 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization.
Ralph P Robinson, Vincent Mascitti, Carine M Boustany-Kari, Christopher L Carr, Patrick M Foley

Bioorg Med Chem Lett· March 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Octahydrophenanthrene-2,7-diol analogues as dissociated glucocorticoid receptor agonists: discovery and lead exploration.
Ralph P Robinson, Leonard Buckbinder, Amber I Haugeto, Patricia A McNiff, Michele L Millham

J Med Chem· March 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent pyrimidinetrione-based inhibitors of MMP-13 with enhanced selectivity over MMP-14.
Julian A Blagg, Mark C Noe, Lilli A Wolf-Gouveia, Lawrence A Reiter, Ellen R Laird, Ralph P Robinson

Bioorg Med Chem Lett· April 2005

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pyran-containing sulfonamide hydroxamic acids: potent MMP inhibitors that spare MMP-1.
Lawrence A Reiter, Ralph P Robinson, Kim F McClure, Christopher S Jones, Matthew R Reese

Bioorg Med Chem Lett· July 2004

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis