Publications by authors named "Tim Ryder"

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An Automated Purification Workflow Coupled with Material-Sparing High-Throughput H NMR for Parallel Medicinal Chemistry.
Justin Bellenger, Martin R M Koos, Melissa Avery, Mark Bundesmann, Gregory Ciszewski, Tim F Ryder

ACS Med Chem Lett· September 2024

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Discovery of the Potent and Selective MC4R Antagonist PF-07258669 for the Potential Treatment of Appetite Loss.
Michelle R Garnsey, Aaron C Smith, Jana Polivkova, Autumn L Arons, Guoyun Bai, Tim Ryder

J Med Chem· March 2023

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Pharmacokinetics, mass balance, metabolism, and excretion of the liver-targeted acetyl-CoA carboxylase inhibitor PF-05221304 (clesacostat) in humans.
Tim F Ryder, Arthur Bergman, Amanda King-Ahmad, Neeta B Amin, Manjinder S Lall

Xenobiotica· March 2022

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Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Anokha S Ratnayake, Mark E Flanagan, Timothy L Foley, Scott L Hultgren, Justin Bellenger, Tim Ryder

Bioorg Med Chem· July 2021

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Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.
Kentaro Futatsugi, Aaron C Smith, Meihua Tu, Brian Raymer, Kay Ahn, Tim Ryder

J Med Chem· November 2020

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Role of Molybdenum-Containing Enzymes in the Biotransformation of the Novel Ghrelin Receptor Inverse Agonist PF-5190457: A Reverse Translational Bed-to-Bench Approach.
Sravani Adusumalli, Rohitash Jamwal, R Scott Obach, Tim F Ryder, Lorenzo Leggio

Drug Metab Dispos· August 2019

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Distribution, Metabolism, and Excretion of Gedatolisib in Healthy Male Volunteers After a Single Intravenous Infusion.
Brett E Houk, Christine W Alvey, Ravi Visswanathan, Leonid Kirkovsky, Kyle T Matschke, Tim Ryder

Clin Pharmacol Drug Dev· January 2019

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Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK).
Tim F Ryder, Matthew F Calabrese, Gregory S Walker, Kimberly O Cameron, Allan R Reyes

J Med Chem· August 2018

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Discovery of a Novel Small-Molecule Modulator of C-X-C Chemokine Receptor Type 7 as a Treatment for Cardiac Fibrosis.
Elnaz Menhaji-Klotz, Kevin D Hesp, Allyn T Londregan, Amit S Kalgutkar, David W Piotrowski, Tim Ryder

J Med Chem· April 2018

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Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1H-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy.
Kimberly O Cameron, Daniel W Kung, Amit S Kalgutkar, Ravi G Kurumbail, Russell Miller, Tim Ryder

J Med Chem· September 2016

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Pharmacokinetics and Disposition of the Thiouracil Derivative PF-06282999, an Orally Bioavailable, Irreversible Inactivator of Myeloperoxidase Enzyme, Across Animals and Humans.
Jennifer Q Dong, Manthena V Varma, Angela Wolford, Tim Ryder, Li Di

Drug Metab Dispos· February 2016

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Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2H)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases.
Roger B Ruggeri, Leonard Buckbinder, Scott W Bagley, Philip A Carpino, Edward L Conn, Tim Ryder

J Med Chem· November 2015

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Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.
Mark E Flanagan, Joseph A Abramite, Dennis P Anderson, Ann Aulabaugh, Upendra P Dahal, Tim Ryder

J Med Chem· December 2014

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Biosynthesis of drug metabolites and quantitation using NMR spectroscopy for use in pharmacologic and drug metabolism studies.
Gregory S Walker, Jonathan N Bauman, Tim F Ryder, Evan B Smith, Douglas K Spracklin

Drug Metab Dispos· October 2014

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The pharmacokinetics, metabolism, and clearance mechanisms of tofacitinib, a janus kinase inhibitor, in humans.
Martin E Dowty, Jinyan Lin, Tim F Ryder, Weiwei Wang, Gregory S Walker

Drug Metab Dispos· April 2014

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Metabolism of a serotonin-4 receptor partial agonist 4-{4-[4-tetrahydrofuran-3-yloxy)-benzo[d]isoxazol-3-yloxymethyl]-piperidin-1-ylmethyl}-tetrahydropyran-4-ol (TBPT): identification of an unusual pharmacologically active cyclized oxazolidine metabolite in human.
Aarti Sawant-Basak, Karen J Coffman, Gregory S Walker, Tim F Ryder, Elaine Tseng

J Pharm Sci· September 2013

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Reactive metabolite trapping studies on imidazo- and 2-methylimidazo[2,1-b]thiazole-based inverse agonists of the ghrelin receptor.
Amit S Kalgutkar, Tim F Ryder, Gregory S Walker, Suvi T M Orr, Shawn Cabral

Drug Metab Dispos· July 2013

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Metabolism, excretion, and pharmacokinetics of ((3,3-difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a dipeptidyl peptidase inhibitor, in rat, dog and human.
Raman Sharma, Hao Sun, David W Piotrowski, Tim F Ryder, Shawn D Doran

Drug Metab Dispos· November 2012

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Insights into the novel hydrolytic mechanism of a diethyl 2-phenyl-2-(2-arylacetoxy)methyl malonate ester-based microsomal triglyceride transfer protein (MTP) inhibitor.
Tim Ryder, Gregory S Walker, Theunis C Goosen, Roger B Ruggeri, Edward L Conn

Chem Res Toxicol· October 2012

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Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
Robert L Walsky, Jonathan N Bauman, Karine Bourcier, Georgina Giddens, Kimberly Lapham, Tim F Ryder

Drug Metab Dispos· May 2012

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Validation of isolated metabolites from drug metabolism studies as analytical standards by quantitative NMR.
Gregory S Walker, Tim F Ryder, Raman Sharma, Evan B Smith, Amy Freund

Drug Metab Dispos· March 2011

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Intrinsic electrophilicity of a 4-substituted-5-cyano-6-(2-methylpyridin-3-yloxy)pyrimidine derivative: structural characterization of glutathione conjugates in vitro.
Amit S Kalgutkar, Vincent Mascitti, Raman Sharma, Gregory W Walker, Tim Ryder

Chem Res Toxicol· February 2011

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Metabolism of ramelteon in human liver microsomes and correlation with the effect of fluvoxamine on ramelteon pharmacokinetics.
R Scott Obach, Tim F Ryder

Drug Metab Dispos· August 2010

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Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Amit S Kalgutkar, David A Griffith, Tim Ryder, Hao Sun, Zhuang Miao

Chem Res Toxicol· June 2010

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Species differences in the biotransformation of an alpha 4 beta 2 nicotinic acetylcholine receptor partial agonist: the effects of distinct glucuronide metabolites on overall compound disposition.
Christopher L Shaffer, Mithat Gunduz, Tim F Ryder, Thomas N O'Connell

Drug Metab Dispos· February 2010

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