Publications by authors named "Ann Aulabaugh"

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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease.
Ariamala Gopalsamy, Ann E Aulabaugh, Amey Barakat, Kevin C Beaumont, Shawn Cabral

J Med Chem· January 2021

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Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors.
Agustin Casimiro-Garcia, John I Trujillo, Felix Vajdos, Brian Juba, Mary Ellen Banker, Ann Aulabaugh

J Med Chem· December 2018

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Rational approach to highly potent and selective apoptosis signal-regulating kinase 1 (ASK1) inhibitors.
Frank Lovering, Paul Morgan, Christophe Allais, Ann Aulabaugh, Joanne Brodfuehrer

Eur J Med Chem· February 2018

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Application of Fluorescence Polarization in HTS Assays.
Xinyi Huang, Ann Aulabaugh

Methods Mol Biol· December 2017

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The catalytic mechanism of cyclic GMP-AMP synthase (cGAS) and implications for innate immunity and inhibition.
Justin Hall, Erik C Ralph, Suman Shanker, Hong Wang, Laura J Byrnes, Ann E Aulabaugh

Protein Sci· December 2017

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Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay.
Justin Hall, Amy Brault, Fabien Vincent, Shawn Weng, Hong Wang, Ann Aulabaugh

PLoS One· October 2017

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The Dual Role of Lipids of the Lipoproteins in Trumenba, a Self-Adjuvanting Vaccine Against Meningococcal Meningitis B Disease.
Yin Luo, Olga V Friese, Herbert A Runnels, Lakshmi Khandke, Gary Zlotnick, Ann Aulabaugh

AAPS J· November 2016

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Cellular thermal shift and clickable chemical probe assays for the determination of drug-target engagement in live cells.
Hua Xu, Ariamala Gopalsamy, Erik C Hett, Shores Salter, Ann Aulabaugh

Org Biomol Chem· July 2016

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Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
Justin D Hall, Hong Wang, Laura J Byrnes, Suman Shanker, Kelong Wang, Ann E Aulabaugh

Protein Sci· February 2016

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Engineered stabilization and structural analysis of the autoinhibited conformation of PDE4.
Peder Cedervall, Ann Aulabaugh, Kieran F Geoghegan, Thomas J McLellan, Jayvardhan Pandit

Proc Natl Acad Sci U S A· March 2015

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Chemical and computational methods for the characterization of covalent reactive groups for the prospective design of irreversible inhibitors.
Mark E Flanagan, Joseph A Abramite, Dennis P Anderson, Ann Aulabaugh, Upendra P Dahal

J Med Chem· December 2014

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Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Seungil Han, Robert M Czerwinski, Nicole L Caspers, David C Limburg, WeiDong Ding, Ann Aulabaugh

Biochem J· June 2014

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A continuous and direct assay to monitor leucine-rich repeat kinase 2 activity.
Rafael G Silva, Kieran F Geoghegan, Xiayang Qiu, Ann Aulabaugh

Anal Biochem· April 2014

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Covalent inhibitors of interleukin-2 inducible T cell kinase (itk) with nanomolar potency in a whole-blood assay.
Christoph W Zapf, Brian S Gerstenberger, Li Xing, David C Limburg, David R Anderson, Ann Aulabaugh

J Med Chem· November 2012

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Biophysical and mechanistic insights into novel allosteric inhibitor of spleen tyrosine kinase.
Justin Hall, Ann Aulabaugh, Francis Rajamohan, Shenping Liu, Neelu Kaila

J Biol Chem· March 2012

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A fluorescent assay suitable for inhibitor screening and vanin tissue quantification.
Benfang H Ruan, Derek C Cole, Paul Wu, Amira Quazi, Karen Page, Ann Aulabaugh

Anal Biochem· April 2010

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Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Pawel Nowak, Derek C Cole, Ann Aulabaugh, Jonathan Bard, Rajiv Chopra

Bioorg Med Chem Lett· January 2010

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3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as potent non-peptidic inhibitors of caspase-3.
Lisa M Havran, Dan C Chong, Wayne E Childers, Paul J Dollings, Arlene Dietrich, Ann Aulabaugh

Bioorg Med Chem· November 2009

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Application of fluorescence polarization in HTS assays.
Xinyi Huang, Ann Aulabaugh

Methods Mol Biol· September 2009

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Activation loop phosphorylation modulates Bruton's tyrosine kinase (Btk) kinase domain activity.
Laura Lin, Robert Czerwinski, Kerry Kelleher, Marshall M Siegel, Paul Wu, Ann Aulabaugh

Biochemistry· March 2009

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Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.
Gareth Williams, Andrew Wood, Emma-Jane Williams, Ying Gao, Mary L Mercado, Ann Aulabaugh

J Biol Chem· June 2008

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Solution structures of 2 : 1 and 1 : 1 DNA polymerase-DNA complexes probed by ultracentrifugation and small-angle X-ray scattering.
Kuo-Hsiang Tang, Marc Niebuhr, Ann Aulabaugh, Ming-Daw Tsai

Nucleic Acids Res· February 2008

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Biochemical and biophysical characterization of inhibitor binding to caspase-3 reveals induced asymmetry.
Ann Aulabaugh, Bhupesh Kapoor, Xinyi Huang, Paul Dollings, Wah-Tung Hum

Biochemistry· August 2007

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Development of an HPLC assay for Staphylococcus aureus sortase: evidence for the formation of the kinetically competent acyl enzyme intermediate.
Ann Aulabaugh, Weidong Ding, Bhupesh Kapoor, Keiko Tabei, Lefa Alksne

Anal Biochem· January 2007

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Acylguanidines as small-molecule beta-secretase inhibitors.
Derek C Cole, Eric S Manas, Joseph R Stock, Jeffrey S Condon, Lee D Jennings, Ann Aulabaugh

J Med Chem· October 2006

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