Publications by authors named "Laura Lin"

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A Robust, High-Titer, Semi-Automated, and In-Culture Antibody-Capturing Transient CHO Platform Technology.
Lauren Gebhardt, Molica Abel, Jing Zhou, Audrey M Vogt, Bo Hee Shin, Laura Lin

Antibodies (Basel)· October 2025

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Structural elucidation of the haptoglobin-hemoglobin clearance mechanism by macrophage scavenger receptor CD163.
Ching-Shin Huang, Hui Wang, Joshua B R White, Oksana Degtjarik, Cindy Huynh, Laura Lin

PLoS Biol· July 2025

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An inducible RIPK3-driven necroptotic system enhances cancer cell-based immunotherapy and ensures safety.
Kok-Siong Chen, Sarah Manoury-Battais, Nobuhiko Kanaya, Ioulia Vogiatzi, Paulo Borges, Laura Y Lin

J Clin Invest· November 2024

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Metabolic Engineering of Glycofusion Bispecific Antibodies for α-Dystroglycanopathies.
Xiaotian Zhong, Guoying Grace Yan, Apurva Chaturvedi, Xiuling Li, Yijie Gao, Laura Lin

Antibodies (Basel)· October 2024

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The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans.
Felicity J Emerson, Caitlin Chiu, Laura Y Lin, Christian G Riedel, Ming Zhu

Nat Commun· March 2024

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Tyrosine Sulfation at Antibody Light Chain CDR-1 Increases Binding Affinity and Neutralization Potency to Interleukine-4.
Aaron M D'Antona, Julie M Lee, Melvin Zhang, Clarence Friedman, Tao He, Laura Lin

Int J Mol Sci· February 2024

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Exploring a role for flow-induced aggregation assays in platform formulation optimisation for antibody-based proteins.
Leon F Willis, Vishal Toprani, Sashini Wijetunge, Annette Sievers, Laura Lin

J Pharm Sci· October 2023

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Exploring Parametric and Mechanistic Differences between Expi293F and ExpiCHO-S Cells for Transient Antibody Production Optimization.
Jing Zhou, Guoying Grace Yan, David Cluckey, Caryl Meade, Margaret Ruth, Laura Lin

Antibodies (Basel)· August 2023

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The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in .
Felicity J Emerson, Caitlin Chiu, Laura Y Lin, Christian G Riedel, Ming Zhu

bioRxiv· March 2023

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Dephosphorylation of Y228 and Y217 and phosphorylation of Y335 in p120 catenin activate convergent extension during zebrafish gastrulation.
Botao Shan, Emma C Horton, Shan C Xu, Kelsey E Huntington, Dane K Kawano, Laura Lin

Dev Dyn· December 2022

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Impacts of fast production of afucosylated antibodies and Fc mutants in ExpiCHO-S™ for enhancing FcγRIIIa binding and NK cell activation.
Xiaotian Zhong, Jennifer Schenk, Paul Sakorafas, John Chamberland, Amy Tam, Laura Lin, Ling Gu, Edward Franklin

J Biotechnol· December 2022

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Reduction of therapeutic antibody self-association using yeast-display selections and machine learning.
Emily K Makowski, Hongwei Chen, Matthew Lambert, Eric M Bennett, Nicole S Eschmann, Laura Lin

MAbs· November 2022

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Cysteine metabolic engineering and selective disulfide reduction produce superior antibody-drug-conjugates.
Renée Procopio-Melino, Frank W Kotch, Amar S Prashad, Jose M Gomes, Wenge Wang, Laura Lin

Sci Rep· May 2022

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Large-Scale Transient Production in ExpiCHO-S™ with Enhanced N-Galactosylation-Sialylation and PEI-Based Transfection.
Xiaotian Zhong, Ashley Schwab, Weijun Ma, Caryl L Meade, Jing Zhou, Laura Lin

Methods Mol Biol· January 2022

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Discovery and optimization of a novel anti-GUCY2c x CD3 bispecific antibody for the treatment of solid tumors.
Adam R Root, Gurkan Guntas, Madan Katragadda, James R Apgar, Jatin Narula, Lindsay King, Laura Lin

MAbs· October 2021

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An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity.
Yuanming Xu, Lucia Campos Carrascosa, Yik Andy Yeung, Matthew Ling-Hon Chu, Wenjing Yang, Laura Lin, Kevin C Lindquist

Cancer Immunol Res· October 2021

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Growth differentiation factor 15 neutralization does not impact anorexia or survival in lipopolysaccharide-induced inflammation.
Danna M Breen, Srinath Jagarlapudi, Anita Patel, Chang Zou, Stephanie Joaquim, Laura Lin

iScience· June 2021

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affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states .
Edwina Stack, Sheridan McMurray, Gordon McMurray, Jason Wade, Melissa Clark, Qingcong Lin, Laura Lin

MAbs· May 2021

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Fc-GDF15 glyco-engineering and receptor binding affinity optimization for body weight regulation.
Ella Fung, Liya Kang, Diana Sapashnik, Susan Benard, Annette Sievers, Linette Rodriguez, Laura Lin

Sci Rep· April 2021

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GDF-15 Neutralization Alleviates Platinum-Based Chemotherapy-Induced Emesis, Anorexia, and Weight Loss in Mice and Nonhuman Primates.
Danna M Breen, Hanna Kim, Donald Bennett, Roberto A Calle, Susie Collins, Laura Lin

Cell Metab· December 2020

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Misuse of Prescription Pain Relievers, Stimulants, Tranquilizers, and Sedatives Among U.S. Older Adults Aged ≥50 Years.
Satomi Odani, Laura C Lin, Jantel R Nelson, Israel T Agaku

Am J Prev Med· December 2020

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Addressing the Chinese food stereotype in health care.
Laura C Lin, Enchi K Chang, Karen He, Melody Huang, Jeremy B Richards

Clin Teach· October 2020

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Modeling and mitigation of high-concentration antibody viscosity through structure-based computer-aided protein design.
James R Apgar, Amy S P Tam, Rhady Sorm, Sybille Moesta, Amy C King, Linette Rodriguez, Laura Lin

PLoS One· August 2020

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Structure-function relationships of the soluble form of the antiaging protein Klotho have therapeutic implications for managing kidney disease.
Xiaotian Zhong, Srinath Jagarlapudi, Yan Weng, Mellisa Ly, Jason C Rouse, Laura Lin

J Biol Chem· March 2020

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Transient CHO expression platform for robust antibody production and its enhanced N-glycan sialylation on therapeutic glycoproteins.
Xiaotian Zhong, Weijun Ma, Caryl L Meade, Amy S Tam, Eliza Llewellyn, Laura Lin

Biotechnol Prog· January 2019

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