Publications by authors named "Benjamin Delprat"

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Positive modulation of sigma-1 receptor: a new weapon to mitigate disease progression in amyotrophic lateral sclerosis.
Julien Le Friec, Hugo Mourier, Simon Couly, Nicolas Cubedo, Kevin Dubois, Benjamin Delprat

Transl Neurodegener· December 2025

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Sigma-1-targeting multimodal compound HBK-15 reverses memory deficits and restores hippocampal plasticity under NMDA hypofunction.
Kinga Sałaciak, Klaudia Lustyk, Angelika Jagielska, Małgorzata Szafarz, Sara Inteiro-Oliveira, Benjamin Delprat

Neurotherapeutics· November 2025

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Improving mitochondria-associated endoplasmic reticulum membranes integrity as converging therapeutic strategy for rare neurodegenerative diseases and cancer.
Michal Cagalinec, Adnan Mohd, Silvia Borecka, Geert Bultynck, Vinay Choubey, Benjamin Delprat

Biochim Biophys Acta Mol Cell Res· June 2025

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Novel in vivo models of autosomal optic atrophy reveal conserved pathological changes in neuronal mitochondrial structure and function.
Elin L Strachan, Eugene T Dillon, Mairéad Sullivan, Jeffrey C Glennon, Amandine Peyrel, Benjamin Delprat

FASEB J· April 2025

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Amylovis-201 is a new dual-target ligand, acting as an anti-amyloidogenic compound and a potent agonist of the chaperone protein.
Laura García-Pupo, Lucie Crouzier, Alberto Bencomo-Martínez, Johann Meunier, Axelle Morilleau, Benjamin Delprat

Acta Pharm Sin B· October 2024

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The Wolfram-like variant WFS1 destabilizes MAM and compromises autophagy and mitophagy in human and mice.
Simone Patergnani, Méghane S Bataillard, Alberto Danese, Stacy Alves, Chantal Cazevieille, Benjamin Delprat

Autophagy· September 2024

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[Local administration of an AAV-TMPRSS3 vector in aged Tmprss3 mutant mice with progressive deafness restores hearing].
Élodie M Richard, Benjamin Delprat

Med Sci (Paris)· May 2024

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Convolamine, a tropane alkaloid extracted from Convolvulus plauricalis, is a potent sigma-1 receptor-positive modulator with cognitive and neuroprotective properties.
Lucie Crouzier, Johann Meunier, Allison Carles, Axelle Morilleau, Cassandre Vrigneau, Benjamin Delprat

Phytother Res· February 2024

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Wfs1 knock-in mice illuminate the fundamental role of Wfs1 in endocochlear potential production.
Elodie M Richard, Emilie Brun, Julia Korchagina, Lucie Crouzier, Corentin Affortit, Benjamin Delprat

Cell Death Dis· June 2023

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Calcium signaling and genetic rare diseases: An auditory perspective.
Elodie M Richard, Tangui Maurice, Benjamin Delprat

Cell Calcium· March 2023

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NCS1 overexpression restored mitochondrial activity and behavioral alterations in a zebrafish model of Wolfram syndrome.
Lucie Crouzier, Elodie M Richard, Camille Diez, Morgane Denus, Amandine Peyrel, Benjamin Delprat

Mol Ther Methods Clin Dev· December 2022

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Sigma-1 receptor agonist PRE-084 confers protection against TAR DNA-binding protein-43 toxicity through NRF2 signalling.
Christelle Lasbleiz, Amandine Peyrel, Pauline Tarot, Jérôme Sarniguet, Lucie Crouzier, Benjamin Delprat

Redox Biol· December 2022

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Morphological, behavioral and cellular analyses revealed different phenotypes in Wolfram syndrome wfs1a and wfs1b zebrafish mutant lines.
Lucie Crouzier, Elodie M Richard, Camille Diez, Hala Alzaeem, Morgane Denus, Benjamin Delprat

Hum Mol Genet· August 2022

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Activation of the sigma-1 receptor chaperone alleviates symptoms of Wolfram syndrome in preclinical models.
Lucie Crouzier, Alberto Danese, Yuko Yasui, Elodie M Richard, Jean-Charles Liévens, Benjamin Delprat

Sci Transl Med· February 2022

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Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ) receptor ligands with potent anti-amnesic effect.
Francesca S Abatematteo, Philip D Mosier, Mauro Niso, Leonardo Brunetti, Francesco Berardi, Benjamin Delprat

Eur J Med Chem· January 2022

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Use of Zebrafish Models to Boost Research in Rare Genetic Diseases.
Lucie Crouzier, Elodie M Richard, Jo Sourbron, Lieven Lagae, Tangui Maurice, Benjamin Delprat

Int J Mol Sci· December 2021

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Sigma-1 Receptor Is Critical for Mitochondrial Activity and Unfolded Protein Response in Larval Zebrafish.
Lucie Crouzier, Morgane Denus, Elodie M Richard, Amarande Tavernier, Camille Diez, Benjamin Delprat

Int J Mol Sci· October 2021

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Variants in USP48 encoding ubiquitin hydrolase are associated with autosomal dominant non-syndromic hereditary hearing loss.
Sissy Bassani, Edward van Beelen, Mireille Rossel, Norine Voisin, Anna Morgan, Benjamin Delprat

Hum Mol Genet· September 2021

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Loss of Pde6a Induces Rod Outer Segment Shrinkage and Visual Alterations in Mutant Zebrafish, a Relevant Model of Retinal Dystrophy.
Lucie Crouzier, Camille Diez, Elodie M Richard, Nicolas Cubedo, Clément Barbereau, Benjamin Delprat

Front Cell Dev Biol· May 2021

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Editorial: Organelles Relationships and Interactions: A Cancer Perspective.
Simone Patergnani, Saverio Marchi, Benjamin Delprat, Mariusz R Wieckowski

Front Cell Dev Biol· April 2021

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Sigma-1 (σ) receptor activity is necessary for physiological brain plasticity in mice.
Lucie Crouzier, Simon Couly, Chloé Roques, Coralie Peter, Rislen Belkhiter, Benjamin Delprat

Eur Neuropsychopharmacol· October 2020

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At the Crossing of ER Stress and MAMs: A Key Role of Sigma-1 Receptor?
Benjamin Delprat, Lucie Crouzier, Tsung-Ping Su, Tangui Maurice

Adv Exp Med Biol· October 2019

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ER-mitochondria cross-talk is regulated by the Ca sensor NCS1 and is impaired in Wolfram syndrome.
Claire Angebault, Jérémy Fauconnier, Simone Patergnani, Jennifer Rieusset, Alberto Danese, Benjamin Delprat

Sci Signal· October 2018

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Wolfram syndrome: MAMs' connection?
Benjamin Delprat, Tangui Maurice, Cécile Delettre

Cell Death Dis· March 2018

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Remodeling of the Inner Hair Cell Microtubule Meshwork in a Mouse Model of Auditory Neuropathy AUNA1.
Clément Surel, Marie Guillet, Marc Lenoir, Jérôme Bourien, Gaston Sendin, Benjamin Delprat

eNeuro· October 2017

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