Publications by authors named "Philip D Mosier"

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Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ) receptor ligands with potent anti-amnesic effect.
Francesca S Abatematteo, Philip D Mosier, Mauro Niso, Leonardo Brunetti, Francesco Berardi

Eur J Med Chem· January 2022

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High-affinity sigma-1 (σ) receptor ligands based on the σ antagonist PB212.
Mauro Niso, Philip D Mosier, Roberta Marottoli, Savina Ferorelli, Giuseppe Cassano

Future Med Chem· October 2019

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"Methylene Bridge" to 5-HT Receptor Antagonists: Conformationally Constrained Phenylguanidines.
Ahmed S Abdelkhalek, Genevieve S Alley, Osama I Alwassil, Shailesh Khatri, Philip D Mosier

ACS Chem Neurosci· March 2019

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Complete Genome Sequences of Bacillus Phages Janet and OTooleKemple52.
Brenna Kent, Thomas Raymond, Philip D Mosier, Allison A Johnson,

Genome Announc· May 2018

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Discovery and Biochemical Characterization of PlyP56, PlyN74, and PlyTB40- Specific Endolysins.
Irina Etobayeva, Sara B Linden, Farhang Alem, Laith Harb, Lucas Rizkalla, Philip D Mosier

Viruses· May 2018

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Structure of the Nanobody-Stabilized Active State of the Kappa Opioid Receptor.
Tao Che, Susruta Majumdar, Saheem A Zaidi, Pauline Ondachi, John D McCorvy, Philip D Mosier

Cell· January 2018

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Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Meng-Jung Chiang, Faik N Musayev, Martina Kosikova, Zhengshi Lin, Yamei Gao, Philip D Mosier

Emerg Microbes Infect· December 2017

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A Hexasaccharide Containing Rare 2-O-Sulfate-Glucuronic Acid Residues Selectively Activates Heparin Cofactor II.
Nehru Viji Sankarayanarayanan, Tamara R Strebel, Rio S Boothello, Kevin Sheerin, Arjun Raghuraman, Philip D Mosier

Angew Chem Int Ed Engl· February 2017

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Superagonist, Full Agonist, Partial Agonist, and Antagonist Actions of Arylguanidines at 5-Hydroxytryptamine-3 (5-HT) Subunit A Receptors.
Katie Alix, Shailesh Khatri, Philip D Mosier, Samantha Casterlow, Dong Yan

ACS Chem Neurosci· November 2016

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Estimating glycosaminoglycan-protein interaction affinity: water dominates the specific antithrombin-heparin interaction.
Aurijit Sarkar, Wenbo Yu, Umesh R Desai, Alexander D MacKerell, Philip D Mosier

Glycobiology· October 2016

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Broad Spectrum Anti-Influenza Agents by Inhibiting Self-Association of Matrix Protein 1.
Philip D Mosier, Meng-Jung Chiang, Zhengshi Lin, Yamei Gao, Bashayer Althufairi

Sci Rep· August 2016

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Solution NMR characterization of chemokine CXCL8/IL-8 monomer and dimer binding to glycosaminoglycans: structural plasticity mediates differential binding interactions.
Prem Raj B Joseph, Philip D Mosier, Umesh R Desai, Krishna Rajarathnam

Biochem J· November 2015

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Crystal structures of influenza A virus matrix protein M1: variations on a theme.
Martin K Safo, Faik N Musayev, Philip D Mosier, Qibing Zhou, Hang Xie

PLoS One· October 2015

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Designing "high-affinity, high-specificity" glycosaminoglycan sequences through computerized modeling.
Nehru Viji Sankaranarayanan, Aurijit Sarkar, Umesh R Desai, Philip D Mosier

Methods Mol Biol· June 2015

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Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.
Eyal Vardy, Maria F Sassano, Andrew J Rennekamp, Wesley K Kroeze, Philip D Mosier

Chem Biol· June 2015

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A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior.
Eyal Vardy, J Elliott Robinson, Chia Li, Reid H J Olsen, Jeffrey F DiBerto, Philip D Mosier

Neuron· May 2015

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Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14β-dihydroxy-4,5α-epoxy-6α-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands.
Yunyun Yuan, Saheem A Zaidi, David L Stevens, Krista L Scoggins, Philip D Mosier

Bioorg Med Chem· April 2015

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Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.
Prabhakar R Polepally, Krzysztof Huben, Eyal Vardy, Vincent Setola, Philip D Mosier

Eur J Med Chem· October 2014

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Binding mode characterization of 6α- and 6β-N-heterocyclic substituted naltrexamine derivatives via docking in opioid receptor crystal structures and site-directed mutagenesis studies: application of the 'message-address' concept in development of mu opioid receptor selective antagonists.
Saheem A Zaidi, Christopher K Arnatt, Hengjun He, Dana E Selley, Philip D Mosier

Bioorg Med Chem· November 2013

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Chemotype-selective modes of action of κ-opioid receptor agonists.
Eyal Vardy, Philip D Mosier, Kevin J Frankowski, Huixian Wu, Vsevolod Katritch

J Biol Chem· November 2013

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On the specificity of heparin/heparan sulfate binding to proteins. Anion-binding sites on antithrombin and thrombin are fundamentally different.
Philip D Mosier, Chandravel Krishnasamy, Glen E Kellogg, Umesh R Desai

PLoS One· May 2013

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The compensatory G88R change is essential in restoring the normal functions of influenza A/WSN/33 virus matrix protein 1 with a disrupted nuclear localization signal.
Hang Xie, Zhengshi Lin, Philip D Mosier, Umesh R Desai, Yamei Gao

J Virol· January 2013

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On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans.
Preetpal S Sidhu, Philip D Mosier, Qibing Zhou, Umesh R Desai

Bioorg Med Chem Lett· January 2013

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Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition.
May H Abdel Aziz, Preetpal Singh Sidhu, Aiye Liang, Ji Yeong Kim, Philip D Mosier

J Med Chem· August 2012

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Structure of the human κ-opioid receptor in complex with JDTic.
Huixian Wu, Daniel Wacker, Mauro Mileni, Vsevolod Katritch, Gye Won Han, Philip D Mosier

Nature· March 2012

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