Publications by authors named "Benjamin Dugan"

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Structure-Activity Relationships and Discovery of ()-5-(-Butyl)-11-(difluoromethoxy)-9-methoxy-2-oxo-1,2,5,6-tetrahydropyrido[2',1':2,3]imidazo[4,5-]quinoline-3-carboxylic Acid (AB-161), a Novel Orally Available and Liver-Centric HBV RNA Destabilizer.
Dimitar Gotchev, Shuai Chen, Benjamin Dugan, Bruce D Dorsey, Xu Wang

J Med Chem· November 2024

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Conformationally Constrained Isoquinolinones as Orally Efficacious Hepatitis B Capsid Assembly Modulators.
Eugen F Mesaros, Andrew G Cole, Steven G Kultgen, Nagraj Mani, Kristi Yi Fan, Benjamin J Dugan

ACS Med Chem Lett· September 2024

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Discovery of -Linked Nucleoside Analogues with Antiviral Activity against SARS-CoV-2.
Eugen F Mesaros, Benjamin J Dugan, Min Gao, Muhammad Sheraz, Kayleigh McGovern-Gooch

ACS Infect Dis· May 2024

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Structure-Activity Relationships and Discovery of ()-6-Isopropyl-2-methoxy-3-(3-methoxypropoxy)-10-oxo-5,10-dihydro-6-pyrido[1,2-][1,7]naphthyridine-9-carboxylic Acid (AB-452), a Novel Orally Available HBV RNA Destabilizer.
Dimitar Gotchev, Bruce D Dorsey, Duyan Nguyen, Ramesh Kakarla, Benjamin Dugan

J Med Chem· January 2024

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Novel Macrocyclic Antagonists of the Calcitonin Gene-Related Peptide Receptor: Design, Realization, and Structural Characterization of Protein-Ligand Complexes.
Andrew D Cansfield, Mark A Ator, Joydeep Banerjee, Michael Bestwick, Andrea Bortolato, Benjamin Dugan

ACS Chem Neurosci· March 2022

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A selective, orally bioavailable 1,2,4-triazolo[1,5-a]pyridine-based inhibitor of Janus kinase 2 for use in anticancer therapy: discovery of CEP-33779.
Benjamin J Dugan, Diane E Gingrich, Eugen F Mesaros, Karen L Milkiewicz, Matthew A Curry

J Med Chem· June 2012

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Depletion of autoreactive plasma cells and treatment of lupus nephritis in mice using CEP-33779, a novel, orally active, selective inhibitor of JAK2.
Lily D Lu, Kristine L Stump, Nate H Wallace, Pawel Dobrzanski, Cynthia Serdikoff, Benjamin J Dugan

J Immunol· October 2011

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Novel 2,3,4,5-tetrahydro-benzo[d]azepine derivatives of 2,4-diaminopyrimidine, selective and orally bioavailable ALK inhibitors with antitumor efficacy in ALCL mouse models.
Eugen F Mesaros, Jason P Burke, Jonathan D Parrish, Benjamin J Dugan, Andrew V Anzalone

Bioorg Med Chem Lett· January 2011

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Oxygen distributions in tissue measured by phosphorescence quenching.
Sergei A Vinogradov, Pavel Grosul, Vladimir Rozhkov, Isolde Dunphy, Lee Shuman, Benjamin W Dugan

Adv Exp Med Biol· August 2003

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Measurement of tumor oxygenation using new frequency domain phosphorometers.
David F Wilson, Sergei A Vinogradov, Benjamin W Dugan, Dubravko Biruski, Lee Waldron

Comp Biochem Physiol A Mol Integr Physiol· May 2002

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