Publications by authors named "Benjamin Dunmore"

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BMP9 knockout impairs pulmonary vessel muscularisation and confers aberrant tamoxifen sensitivity.
Benjamin J Dunmore, Stephen Moore, Rowena J Jones, Joshua Hodgson, Kathryn Auckland

Angiogenesis· November 2025

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Activin-A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type-II Receptor Expression.
Benjamin J Dunmore, Nobuhiro Kikuchi, Wei Li, Paul D Upton, Nicholas W Morrell

Pulm Circ· April 2025

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SEMA3G regulates BMP9 inhibition of VEGF-mediated migration and network formation in pulmonary endothelial cells.
Sarah L Mirza, Paul D Upton, Joshua Hodgson, Stefan Gräf, Nicholas W Morrell, Benjamin J Dunmore

Vascul Pharmacol· June 2024

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An emerging class of new therapeutics targeting TGF, Activin, and BMP ligands in pulmonary arterial hypertension.
Paul D Upton, Benjamin J Dunmore, Wei Li, Nicholas W Morrell

Dev Dyn· March 2023

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Reduced circulating BMP9 and pBMP10 in hospitalized COVID-19 patients.
Benjamin J Dunmore, Paul D Upton, Kate Auckland, Romit J Samanta,

Pulm Circ· January 2023

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An organ-on-chip model of pulmonary arterial hypertension identifies a BMPR2-SOX17-prostacyclin signalling axis.
Alexander J Ainscough, Timothy J Smith, Maike Haensel, Christopher J Rhodes, Adam Fellows, Benjamin Dunmore

Commun Biol· November 2022

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The impact of hypoxia on B cells in COVID-19.
Prasanti Kotagiri, Federica Mescia, Aimee L Hanson, Lorinda Turner, Laura Bergamaschi, Benjamin J Dunmore

EBioMedicine· March 2022

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Approaches to treat pulmonary arterial hypertension by targeting BMPR2: from cell membrane to nucleus.
Benjamin J Dunmore, Rowena J Jones, Mark R Toshner, Paul D Upton, Nicholas W Morrell

Cardiovasc Res· September 2021

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Longitudinal analysis reveals that delayed bystander CD8+ T cell activation and early immune pathology distinguish severe COVID-19 from mild disease.
Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aimee L Hanson, Prasanti Kotagiri, Benjamin J Dunmore

Immunity· June 2021

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4PBA Restores Signaling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with Pulmonary Arterial Hypertension.
Benjamin J Dunmore, XuDong Yang, Alexi Crosby, Stephen Moore, Lu Long

Am J Respir Cell Mol Biol· August 2020

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Targeting translational read-through of premature termination mutations in with PTC124 for pulmonary arterial hypertension.
Lu Long, Xudong Yang, Mark Southwood, Stephen Moore, Alexi Crosby, Benjamin J Dunmore

Pulm Circ· July 2020

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A Potential Role for Exosomal Translationally Controlled Tumor Protein Export in Vascular Remodeling in Pulmonary Arterial Hypertension.
Elisabet Ferrer, Benjamin J Dunmore, Dhiya Hassan, Mark L Ormiston, Stephen Moore

Am J Respir Cell Mol Biol· October 2018

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Hematopoietic stem cell transplantation alters susceptibility to pulmonary hypertension in Bmpr2-deficient mice.
Alexi Crosby, Mark R Toshner, Mark R Southwood, Elaine Soon, Benjamin J Dunmore

Pulm Circ· August 2018

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Contributions of BMPR2 Mutations and Extrinsic Factors to Cellular Phenotypes of Pulmonary Arterial Hypertension Revealed by Induced Pluripotent Stem Cell Modeling.
Fedir N Kiskin, C-Hong Chang, Christopher J Z Huang, Baraa Kwieder, Christine Cheung, Benjamin J Dunmore

Am J Respir Crit Care Med· July 2018

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Identification of MicroRNA-124 as a Major Regulator of Enhanced Endothelial Cell Glycolysis in Pulmonary Arterial Hypertension via PTBP1 (Polypyrimidine Tract Binding Protein) and Pyruvate Kinase M2.
Paola Caruso, Benjamin J Dunmore, Kenny Schlosser, Sandra Schoors, Claudia Dos Santos

Circulation· December 2017

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TNFα drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
Liam A Hurst, Benjamin J Dunmore, Lu Long, Alexi Crosby, Rafia Al-Lamki

Nat Commun· January 2017

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Ageing is associated with molecular signatures of inflammation and type 2 diabetes in rat pancreatic islets.
Ionel Sandovici, Constanze M Hammerle, Wendy N Cooper, Noel H Smith, Jane L Tarry-Adkins, Benjamin J Dunmore

Diabetologia· March 2016

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Caveolae protect endothelial cells from membrane rupture during increased cardiac output.
Jade P X Cheng, Carolina Mendoza-Topaz, Gillian Howard, Jessica Chadwick, Elena Shvets, Benjamin J Dunmore

J Cell Biol· October 2015

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Transcript analysis reveals a specific HOX signature associated with positional identity of human endothelial cells.
Mark Toshner, Benjamin J Dunmore, Eoin F McKinney, Mark Southwood, Paola Caruso

PLoS One· December 2014

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Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension.
Kylie M Drake, Benjamin J Dunmore, Lauren N McNelly, Nicholas W Morrell, Micheala A Aldred

Am J Respir Cell Mol Biol· September 2013

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The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations.
Benjamin J Dunmore, Kylie M Drake, Paul D Upton, Mark R Toshner, Micheala A Aldred

Hum Mol Genet· September 2013

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Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation.
Lu Long, Xudong Yang, Mark Southwood, Junyu Lu, Stefan J Marciniak, Benjamin J Dunmore

Circ Res· April 2013

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Vasohibin-1 is identified as a master-regulator of endothelial cell apoptosis using gene network analysis.
Muna Affara, Debbie Sanders, Hiromitsu Araki, Yoshinori Tamada, Benjamin J Dunmore

BMC Genomics· January 2013

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MMP1 bimodal expression and differential response to inflammatory mediators is linked to promoter polymorphisms.
Muna Affara, Benjamin J Dunmore, Deborah A Sanders, Nicola Johnson, Cristin G Print

BMC Genomics· January 2011

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Bone morphogenetic protein type II receptor mutations causing protein misfolding in heritable pulmonary arterial hypertension.
Wei Li, Benjamin J Dunmore, Nicholas W Morrell

Proc Am Thorac Soc· November 2010

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