Publications by authors named "Benoit Lechat"

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Intrinsic resistance to RAS inhibitors is driven by dysregulation of KRAS degradation.
Tonci Ivanisevic, Yan Ma, Emiel Van Boxel, Wout Magits, Benoit Lechat

Nat Commun· December 2025

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K128 ubiquitination constrains RAS activity by expanding its binding interface with GAP proteins.
Wout Magits, Mikhail Steklov, Hyunbum Jang, Raj N Sewduth, Amir Florentin, Benoit Lechat

EMBO J· July 2024

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Targeted STAT1 therapy for LZTR1-driven peripheral nerve sheath tumor.
Tonci Ivanisevic, Mikhail Steklov, Benoit Lechat, Christopher Cawthorne, Willy Gsell

Cancer Commun (Lond)· December 2023

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Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination.
Raj N Sewduth, Paolo Carai, Tonci Ivanisevic, Mingzhen Zhang, Hyunbum Jang, Benoit Lechat

Adv Sci (Weinh)· December 2023

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Loss-of-Function Mutations in TRAF7 and KLF4 Cooperatively Activate RAS-Like GTPase Signaling and Promote Meningioma Development.
Paul Najm, Peihua Zhao, Mikhail Steklov, Raj Nayan Sewduth, Maria Francesca Baietti, Benoit Lechat

Cancer Res· August 2021

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Syntenin-knock out reduces exosome turnover and viral transduction.
Rudra Kashyap, Marielle Balzano, Benoit Lechat, Kathleen Lambaerts, Antonio Luis Egea-Jimenez

Sci Rep· February 2021

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The Noonan Syndrome Gene Controls Cardiovascular Function by Regulating Vesicular Trafficking.
Raj Nayan Sewduth, Silvia Pandolfi, Mikhail Steklov, Aidana Sheryazdanova, Peihua Zhao, Benoit Lechat

Circ Res· May 2020

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Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3.
Linde De Troyer, Peihua Zhao, Tibor Pastor, Maria Francesca Baietti, Jasmine Barra, Benoit Lechat

Nucleic Acids Res· May 2020

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Stress-induced lncRNA LASTR fosters cancer cell fitness by regulating the activity of the U4/U6 recycling factor SART3.
Linde De Troyer, Peihua Zhao, Tibor Pastor, Maria Francesca Baietti, Jasmine Barra, Benoit Lechat

Nucleic Acids Res· March 2020

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LRP1 Has a Predominant Role in Production over Clearance of Aβ in a Mouse Model of Alzheimer's Disease.
Bart Van Gool, Steffen E Storck, Sara M Reekmans, Benoit Lechat, Philip L S M Gordts

Mol Neurobiol· October 2019

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Regional vulnerability and spreading of hyperphosphorylated tau in seeded mouse brain.
Jan R Detrez, Hervé Maurin, Kristof Van Kolen, Roland Willems, Julien Colombelli, Benoit Lechat

Neurobiol Dis· July 2019

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Single mild traumatic brain injury results in transiently impaired spatial long-term memory and altered search strategies.
Linda Marschner, An Schreurs, Benoit Lechat, Jesper Mogensen, Anton Roebroek

Behav Brain Res· June 2019

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Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology.
Kristof Govaerts, Benoit Lechat, Tom Struys, Anna Kremer, Peter Borghgraef

NMR Biomed· February 2019

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GSK3β activity alleviates epileptogenesis and limits GluA1 phosphorylation.
Malgorzata Urbanska, Paulina Kazmierska-Grebowska, Tomasz Kowalczyk, Bartosz Caban, Karolina Nader, Benoit Lechat

EBioMedicine· January 2019

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GSK3β Controls mTOR and Prosurvival Signaling in Neurons.
Malgorzata Urbanska, Agata Gozdz, Matylda Macias, Iwona A Cymerman, Ewa Liszewska, Benoit Lechat

Mol Neurobiol· July 2018

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GSK-3β and MMP-9 Cooperate in the Control of Dendritic Spine Morphology.
Ilona Kondratiuk, Szymon Łęski, Małgorzata Urbańska, Przemysław Biecek, Herman Devijver, Benoit Lechat

Mol Neurobiol· January 2017

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Early structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.
Hervé Maurin, Seon-Ah Chong, Igor Kraev, Heather Davies, Anna Kremer, Benoit Lechat

PLoS One· December 2014

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Phosphorylation of protein Tau by GSK3β prolongs survival of bigenic Tau.P301L×GSK3β mice by delaying brainstem tauopathy.
Natalia Crespo-Biel, Clara Theunis, Peter Borghgraef, Benoit Lechat, Herman Devijver

Neurobiol Dis· July 2014

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Terminal hypothermic Tau.P301L mice have increased Tau phosphorylation independently of glycogen synthase kinase 3α/β.
Hervé Maurin, Benoit Lechat, Peter Borghgraef, Herman Devijver, Tomasz Jaworski

Eur J Neurosci· July 2014

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Tauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.
Hervé Maurin, Claire Marie Seymour, Benoit Lechat, Peter Borghgraef, Herman Devijver

PLoS One· December 2013

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Glycogen synthase kinase-3beta affects size of dentate gyrus and species-typical behavioral tasks in transgenic and knockout mice.
Ilona Kondratiuk, Herman Devijver, Benoit Lechat, Fred Van Leuven, Leszek Kaczmarek

Behav Brain Res· July 2013

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Glycogen synthase kinase-3β (GSK3β) expression in a mouse model of Alzheimer's disease: a light and electron microscopy study.
Johanna C Gandy, Miguel Melendez-Ferro, Gautam N Bijur, Fred Van Leuven, Joy K Roche, Benoit Lechat

Synapse· June 2013

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Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.
Hervé Maurin, Benoit Lechat, Ilse Dewachter, Laurence Ris, Justin V Louis

Mol Brain· May 2013

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GSK-3α/β kinases and amyloid production in vivo.
Tomasz Jaworski, Ilse Dewachter, Benoit Lechat, Maarten Gees, Anna Kremer

Nature· December 2011

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Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration.
Tomasz Jaworski, Benoit Lechat, David Demedts, Lies Gielis, Herman Devijver

Am J Pathol· October 2011

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