Publications by authors named "Bernard Roques"

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Molecular mechanisms in Alzheimer's disease and related potential treatments such as structural target convergence of antibodies and simple organic molecules.
Nassima Oumata, Kui Lu, Yuou Teng, Christian Cavé, Yu Peng, Bernard P Roques

Eur J Med Chem· October 2022

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Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer's disease (AD) mouse model and is increased at early stage in sporadic AD brain.
Audrey Valverde, Julie Dunys, Thomas Lorivel, Delphine Debayle, Anne-Sophie Gay, Bernard P Roques

Acta Neuropathol· June 2021

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Positive allosteric modulation of the mu-opioid receptor produces analgesia with reduced side effects.
Ram Kandasamy, Todd M Hillhouse, Kathryn E Livingston, Kelsey E Kochan, Claire Meurice, Bernard P Roques

Proc Natl Acad Sci U S A· April 2021

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Structural insight into the catalytic mechanism and inhibitor binding of aminopeptidase A.
Pierre Couvineau, Hugo De Almeida, Vincent Leroux, Bernard Roques, Bernard Maigret

Biochem J· November 2020

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NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension.
Mathilde Keck, Hugo De Almeida, Delphine Compère, Nicolas Inguimbert, Adrien Flahault, Bernard Roques

Hypertension· June 2019

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Contribution of Delta-Opioid Receptors to Pathophysiological Events Explored by Endogenous Enkephalins.
Bernard P Roques

Handb Exp Pharmacol· January 2019

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Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries.
Phillip G Kopf, Sang-Kyu Park, Anja Herrnreiter, Christian Krause, Bernard P Roques

Endocrinology· January 2018

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Substituted α-mercaptoketones, new types of specific neprilysin inhibitors.
Hervé Poras, Rémi Patouret, Simon Leiris, Tanja Ouimet, Marie-Claude Fournié-Zaluski, Bernard P Roques

Bioorg Med Chem Lett· August 2017

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Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain.
Sara González-Rodríguez, Hervé Poras, Luis Menéndez, Ana Lastra, Tanja Ouimet, Bernard P Roques

Scand J Pain· January 2017

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Preventive and alleviative effects of the dual enkephalinase inhibitor (Denki) PL265 in a murine model of neuropathic pain.
Elisabeth Bonnard, Hervé Poras, Marie-Claude Fournié-Zaluski, Bernard P Roques

Eur J Pharmacol· October 2016

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Modulation of disulfide dual ENKephalinase inhibitors (DENKIs) activity by a transient N-protection for pain alleviation by oral route.
Hervé Poras, Elisabeth Bonnard, Marie-Claude Fournié-Zaluski, Bernard P Roques

Eur J Med Chem· September 2015

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Long-lasting oral analgesic effects of N-protected aminophosphinic dual ENKephalinase inhibitors (DENKIs) in peripherally controlled pain.
Elisabeth Bonnard, Hervé Poras, Xavier Nadal, Rafael Maldonado, Marie-Claude Fournié-Zaluski, Bernard P Roques

Pharmacol Res Perspect· March 2015

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New orally active dual enkephalinase inhibitors (DENKIs) for central and peripheral pain treatment.
Hervé Poras, Elisabeth Bonnard, Emilie Dangé, Marie-Claude Fournié-Zaluski, Bernard P Roques

J Med Chem· July 2014

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Randomised, double-blind, placebo-controlled, dose-escalating phase I study of QGC001, a centrally acting aminopeptidase a inhibitor prodrug.
Fabrice Balavoine, Michel Azizi, Damien Bergerot, Nadia De Mota, Rémi Patouret, Bernard P Roques

Clin Pharmacokinet· April 2014

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TGF-β and opioid receptor signaling crosstalk results in improvement of endogenous and exogenous opioid analgesia under pathological pain conditions.
Aquilino Lantero, Mónica Tramullas, Fuencisla Pílar-Cuellar, Elsa Valdizán, Rosa Santillán, Bernard P Roques

J Neurosci· April 2014

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Cocaine dysregulates opioid gating of GABA neurotransmission in the ventral pallidum.
Yonatan M Kupchik, Michael D Scofield, Kenner C Rice, Kejun Cheng, Bernard P Roques

J Neurosci· January 2014

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A sensitive fluorigenic substrate for selective in vitro and in vivo assay of leukotriene A4 hydrolase activity.
Hervé Poras, Sophie Duquesnoy, Marie-Claude Fournié-Zaluski, Céline Ratinaud-Giraud, Bernard P Roques

Anal Biochem· October 2013

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Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity.
Tanja Ouimet, Sophie Duquesnoy, Hervé Poras, Marie-Claude Fournié-Zaluski, Bernard P Roques

J Biomol Screen· July 2013

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Pain inhibition by blocking leukocytic and neuronal opioid peptidases in peripheral inflamed tissue.
Anja Schreiter, Carmen Gore, Dominika Labuz, Marie-Claude Fournie-Zaluski, Bernard P Roques

FASEB J· December 2012

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Central antihypertensive effects of orally active aminopeptidase A inhibitors in spontaneously hypertensive rats.
Yannick Marc, Ji Gao, Fabrice Balavoine, Annie Michaud, Bernard P Roques

Hypertension· August 2012

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[New painkillers inhibiting the physiological breakdown of endogenous opioids].
Bernard P Roques, Marie-Claude Fournié-Zaluski, Michel Wurm

Med Sci (Paris)· May 2012

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Molecular and cellular targets of the MRI contrast agent P947 for atherosclerosis imaging.
Tanja Ouimet, Eric Lancelot, Fabien Hyafil, Mario Rienzo, François Deux, Bernard P Roques

Mol Pharm· April 2012

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Inhibiting the breakdown of endogenous opioids and cannabinoids to alleviate pain.
Bernard P Roques, Marie-Claude Fournié-Zaluski, Michel Wurm

Nat Rev Drug Discov· April 2012

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Endogenous opioids as physiological antidepressants: complementary role of δ receptors and dopamine.
Emily M Jutkiewicz, Bernard P Roques

Neuropsychopharmacology· January 2012

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Pluripotentialities of a quenched fluorescent peptide substrate library: enzymatic detection, characterization, and isoenzymes differentiation.
Hervé Poras, Tanja Ouimet, Sou-Vinh Orng, Emilie Dangé, Marie-Claude Fournié-Zaluski, Bernard P Roques

Anal Biochem· December 2011

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