Publications by authors named "Bernhard Helk"

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Towards more tolerable subcutaneous administration: Review of contributing factors for improving combination product design.
Neil Mathias, Sylvain Huille, Marie Picci, Robert P Mahoney, Ronald J Pettis, Bernhard Helk

Adv Drug Deliv Rev· June 2024

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Computational tool for the early screening of monoclonal antibodies for their viscosities.
Neeraj J Agrawal, Bernhard Helk, Sandeep Kumar, Neil Mody, Hasige A Sathish

MAbs· September 2016

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Enabling low cost biopharmaceuticals: high level interferon alpha-2b production in Trichoderma reesei.
Christopher P Landowski, Eero Mustalahti, Ramon Wahl, Laurence Croute, Dhinakaran Sivasiddarthan, Bernhard Helk

Microb Cell Fact· June 2016

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Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei.
Christopher P Landowski, Anne Huuskonen, Ramon Wahl, Ann Westerholm-Parvinen, Anne Kanerva, Bernhard Helk

PLoS One· May 2016

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Ethanol precipitation for purification of recombinant antibodies.
Anne Tscheliessnig, Peter Satzer, Nikolaus Hammerschmidt, Henk Schulz, Bernhard Helk

J Biotechnol· October 2014

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Economics of recombinant antibody production processes at various scales: Industry-standard compared to continuous precipitation.
Nikolaus Hammerschmidt, Anne Tscheliessnig, Ralf Sommer, Bernhard Helk, Alois Jungbauer

Biotechnol J· June 2014

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A computational tool to predict the evolutionarily conserved protein-protein interaction hot-spot residues from the structure of the unbound protein.
Neeraj J Agrawal, Bernhard Helk, Bernhardt L Trout

FEBS Lett· January 2014

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Fast and scalable purification of a therapeutic full-length antibody based on process crystallization.
Benjamin Smejkal, Neeraj J Agrawal, Bernhard Helk, Henk Schulz, Marion Giffard, Matthias Mechelke

Biotechnol Bioeng· September 2013

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Emergent properties of nanosensor arrays: applications for monitoring IgG affinity distributions, weakly affined hypermannosylation, and colony selection for biomanufacturing.
Nigel F Reuel, Brittany Grassbaugh, Sebastian Kruss, J Zachary Mundy, Cary Opel, Bernhard Helk

ACS Nano· September 2013

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Chinese hamster genome sequenced from sorted chromosomes.
Karina Brinkrolf, Oliver Rupp, Holger Laux, Florian Kollin, Wolfgang Ernst, Bernhard Helk

Nat Biotechnol· August 2013

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Protein crystallization in stirred systems--scale-up via the maximum local energy dissipation.
Benjamin Smejkal, Bernhard Helk, Jean-Michel Rondeau, Sabine Anton, Angelika Wilke

Biotechnol Bioeng· July 2013

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Structure-activity relationship for hydrophobic salts as viscosity-lowering excipients for concentrated solutions of monoclonal antibodies.
Zheng Guo, Alvin Chen, Roger A Nassar, Bernhard Helk, Claudia Mueller

Pharm Res· November 2012

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Conformational stability and aggregation of therapeutic monoclonal antibodies studied with ANS and Thioflavin T binding.
Veysel Kayser, Naresh Chennamsetty, Vladimir Voynov, Bernhard Helk, Bernhardt L Trout

MAbs· January 2012

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Developability index: a rapid in silico tool for the screening of antibody aggregation propensity.
Timothy M Lauer, Neeraj J Agrawal, Naresh Chennamsetty, Kamal Egodage, Bernhard Helk

J Pharm Sci· January 2012

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A screening tool for therapeutic monoclonal antibodies: Identifying the most stable protein and its best formulation based on thioflavin T binding.
Veysel Kayser, Naresh Chennamsetty, Vladimir Voynov, Bernhard Helk, Kurt Forrer

Biotechnol J· January 2012

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Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions.
Neeraj J Agrawal, Sandeep Kumar, Xiaoling Wang, Bernhard Helk, Satish K Singh

J Pharm Sci· December 2011

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Evaluation of a non-Arrhenius model for therapeutic monoclonal antibody aggregation.
Veysel Kayser, Naresh Chennamsetty, Vladimir Voynov, Bernhard Helk, Kurt Forrer

J Pharm Sci· July 2011

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Prediction of protein binding regions.
Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser, Bernhard Helk, Bernhardt L Trout

Proteins· March 2011

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Tryptophan-tryptophan energy transfer and classification of tryptophan residues in proteins using a therapeutic monoclonal antibody as a model.
Veysel Kayser, Naresh Chennamsetty, Vladimir Voynov, Bernhard Helk, Bernhardt L Trout

J Fluoresc· January 2011

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Glycosylation influences on the aggregation propensity of therapeutic monoclonal antibodies.
Veysel Kayser, Naresh Chennamsetty, Vladimir Voynov, Kurt Forrer, Bernhard Helk

Biotechnol J· January 2011

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Predictive tools for stabilization of therapeutic proteins.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Bernhard Helk, Bernhardt L Trout

MAbs· June 2010

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Prediction of aggregation prone regions of therapeutic proteins.
Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser, Bernhard Helk, Bernhardt L Trout

J Phys Chem B· May 2010

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Design and application of antibody cysteine variants.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Hans-Joachim Wallny, Bernhard Helk

Bioconjug Chem· February 2010

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Dynamic fluctuations of protein-carbohydrate interactions promote protein aggregation.
Vladimir Voynov, Naresh Chennamsetty, Veysel Kayser, Bernhard Helk, Kurt Forrer

PLoS One· December 2009

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Design of therapeutic proteins with enhanced stability.
Naresh Chennamsetty, Vladimir Voynov, Veysel Kayser, Bernhard Helk, Bernhardt L Trout

Proc Natl Acad Sci U S A· July 2009

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