Publications by authors named "Beth Ostaszewski"

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An improved immunoassay detects Aβ oligomers in human biofluids: their CSF levels rise with tau and phosphotau levels.
Ting Yang, Yi Ran Xu, Shanxue Jin, Nagendran Ramalingam, Jean-Pierre Bellier, Beth L Ostaszewski

Alzheimers Res Ther· July 2025

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Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts.
Andrew M Stern, Kathryn L Van Pelt, Lei Liu, Amirah K Anderson, Beth Ostaszewski

Alzheimers Dement· December 2023

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Plasma NT1-tau and Aβ correlate with age and cognitive function in two large Down syndrome cohorts.
Andrew M Stern, Kathryn L Van Pelt, Lei Liu, Amirah K Anderson, Beth Ostaszewski

medRxiv· March 2023

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Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials.
Susanne Ostrowitzki, Tobias Bittner, Kaycee M Sink, Howard Mackey, Christina Rabe, Beth Ostaszewski

JAMA Neurol· November 2022

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An ultra-sensitive immunoassay detects and quantifies soluble Aβ oligomers in human plasma.
Lei Liu, Hyunchang Kwak, Trebor L Lawton, Shan-Xue Jin, Angela L Meunier, Beth Ostaszewski

Alzheimers Dement· June 2022

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Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals.
Jasmeer P Chhatwal, Aaron P Schultz, Yifan Dang, Beth Ostaszewski, Lei Liu

Nat Commun· November 2020

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Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.
Ting Yang, Yifan Dang, Beth Ostaszewski, David Mengel, Verena Steffen

Ann Neurol· August 2019

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Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.
Shaomin Li, Ming Jin, Lei Liu, Yifan Dang, Beth L Ostaszewski

Acta Neuropathol Commun· November 2018

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Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.
Alfred T Welzel, John E Maggio, Ganesh M Shankar, Donald E Walker, Beth L Ostaszewski

Biochemistry· June 2014

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Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.
Soyon Hong, Beth L Ostaszewski, Ting Yang, Tiernan T O'Malley, Ming Jin

Neuron· April 2014

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Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Aβ by microglia.
Hongjun Fu, Bin Liu, Jeffrey L Frost, Soyon Hong, Ming Jin, Beth Ostaszewski

Glia· May 2012

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Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation.
Soyon Hong, Omar Quintero-Monzon, Beth L Ostaszewski, Daniel R Podlisny, William T Cavanaugh

J Neurosci· November 2011

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Aph-1 associates directly with full-length and C-terminal fragments of gamma-secretase substrates.
Allen C Chen, Lucie Y Guo, Beth L Ostaszewski, Dennis J Selkoe, Matthew J LaVoie

J Biol Chem· April 2010

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Pink1 forms a multiprotein complex with Miro and Milton, linking Pink1 function to mitochondrial trafficking.
Andreas Weihofen, Kelly Jean Thomas, Beth L Ostaszewski, Mark R Cookson, Dennis J Selkoe

Biochemistry· March 2009

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Pink1 Parkinson mutations, the Cdc37/Hsp90 chaperones and Parkin all influence the maturation or subcellular distribution of Pink1.
Andreas Weihofen, Beth Ostaszewski, Yasufumi Minami, Dennis J Selkoe

Hum Mol Genet· February 2008

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The effects of oxidative stress on parkin and other E3 ligases.
Matthew J LaVoie, Giuseppe P Cortese, Beth L Ostaszewski, Michael G Schlossmacher

J Neurochem· December 2007

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gamma-Secretase substrate selectivity can be modulated directly via interaction with a nucleotide-binding site.
Patrick C Fraering, Wenjuan Ye, Matthew J LaVoie, Beth L Ostaszewski, Dennis J Selkoe

J Biol Chem· December 2005

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Dopamine covalently modifies and functionally inactivates parkin.
Matthew J LaVoie, Beth L Ostaszewski, Andreas Weihofen, Michael G Schlossmacher, Dennis J Selkoe

Nat Med· November 2005

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Purification and characterization of the human gamma-secretase complex.
Patrick C Fraering, Wenjuan Ye, Jean-Marc Strub, Georgia Dolios, Matthew J LaVoie, Beth L Ostaszewski

Biochemistry· August 2004

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Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.
Patrick C Fraering, Matthew J LaVoie, Wenjuan Ye, Beth L Ostaszewski, W Taylor Kimberly

Biochemistry· January 2004

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Assembly of the gamma-secretase complex involves early formation of an intermediate subcomplex of Aph-1 and nicastrin.
Matthew J LaVoie, Patrick C Fraering, Beth L Ostaszewski, Wenjuan Ye, W Taylor Kimberly

J Biol Chem· September 2003

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Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.
W Taylor Kimberly, Matthew J LaVoie, Beth L Ostaszewski, Wenjuan Ye, Michael S Wolfe

Proc Natl Acad Sci U S A· May 2003

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Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).
W Taylor Kimberly, William P Esler, Wenjuan Ye, Beth L Ostaszewski, Jun Gao

Biochemistry· January 2003

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Complex N-linked glycosylated nicastrin associates with active gamma-secretase and undergoes tight cellular regulation.
W Taylor Kimberly, Matthew J LaVoie, Beth L Ostaszewski, Wenjuan Ye, Michael S Wolfe

J Biol Chem· September 2002

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Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
William P Esler, Chittaranjan Das, William A Campbell, W Taylor Kimberly, Anna Y Kornilova, Beth L Ostaszewski

Nat Cell Biol· May 2002

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