Publications by authors named "Birgit Kosjek"

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Engineering Hydroxylase Activity, Selectivity, and Stability for a Scalable Concise Synthesis of a Key Intermediate to Belzutifan.
Wai Ling Cheung-Lee, Joshua N Kolev, John A McIntosh, Agnieszka A Gil, Weilan Pan, Birgit Kosjek

Angew Chem Int Ed Engl· March 2024

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Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.
Yong-Li Zhong, Jeffrey C Moore, Michael Shevlin, C Scott Shultz, Birgit Kosjek

J Org Chem· February 2022

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Recent preparative applications of redox enzymes.
Christopher K Prier, Birgit Kosjek

Curr Opin Chem Biol· April 2019

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Synthesis of Vibegron Enabled by a Ketoreductase Rationally Designed for High pH Dynamic Kinetic Reduction.
Feng Xu, Birgit Kosjek, Fabien L Cabirol, Haibin Chen, Richard Desmond

Angew Chem Int Ed Engl· June 2018

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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.
Alan M Hyde, Zhijian Liu, Birgit Kosjek, Lushi Tan, Artis Klapars

Org Lett· November 2016

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Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.
Hongmei Li, Jeremy P Scott, Cheng-yi Chen, Michel Journet, Kevin Belyk, Birgit Kosjek

Org Lett· March 2015

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CRTH2 antagonist MK-7246: a synthetic evolution from discovery through development.
Carmela Molinaro, Paul G Bulger, Ernest E Lee, Birgit Kosjek, Stephen Lau

J Org Chem· March 2012

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Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Michel Gallant, Christian Beaulieu, Carl Berthelette, John Colucci, Michael A Crackower, Birgit Kosjek

Bioorg Med Chem Lett· January 2011

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Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis.
Carmela Molinaro, Audrey-Anne Guilbault, Birgit Kosjek

Org Lett· September 2010

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Advances in the enzymatic reduction of ketones.
Jeffrey C Moore, David J Pollard, Birgit Kosjek, Paul N Devine

Acc Chem Res· December 2007

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Chemo- and enantioselective routes to chiral fluorinated hydroxyketones using ketoreductases.
Brendan T Grau, Paul N Devine, Lisa N DiMichele, Birgit Kosjek

Org Lett· November 2007

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Purification and characterization of a chemotolerant alcohol dehydrogenase applicable to coupled redox reactions.
Birgit Kosjek, Wolfgang Stampfer, Mateja Pogorevc, Walter Goessler, Kurt Faber

Biotechnol Bioeng· April 2004

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On the organic solvent and thermostability of the biocatalytic redox system of Rhodococcus ruber DSM 44541.
Wolfgang Stampfer, Birgit Kosjek, Wolfgang Kroutil, Kurt Faber

Biotechnol Bioeng· March 2003

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Biocatalytic asymmetric hydrogen transfer employing Rhodococcus ruber DSM 44541.
Wolfgang Stampfer, Birgit Kosjek, Kurt Faber, Wolfgang Kroutil

J Org Chem· January 2003

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Biocatalytic asymmetric hydrogen transfer.
Wolfgang Stampfer, Birgit Kosjek, Christian Moitzi, Wolfgang Kroutil, Kurt Faber

Angew Chem Int Ed Engl· March 2002

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