Publications by authors named "Lushi Tan"

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Total Synthesis of Enlicitide Decanoate.
Hongming Li, David A Thaisrivongs, Gao Shang, Yonggang Chen, Qinghao Chen, Lushi Tan, Weijuan Tang

J Am Chem Soc· April 2025

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A Unified Strategy to Fluorinated Nucleoside Analogues an Electrophilic Manifold.
Andrew J Neel, Ben W H Turnbull, William P Carson, Tamas Benkovics, Cheol K Chung, Lushi Tan

Org Lett· October 2022

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Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454.
Tamas Benkovics, Feng Peng, Eric M Phillips, Chihui An, Rachel S Bade, Lushi Tan

J Am Chem Soc· April 2022

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Scalable Asymmetric Synthesis of MK-8998, a T-Type Calcium Channel Antagonist.
Yong-Li Zhong, Jeffrey C Moore, Michael Shevlin, C Scott Shultz, Birgit Kosjek, Lushi Tan

J Org Chem· February 2022

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Development of a Robust Manufacturing Route for Molnupiravir, an Antiviral for the Treatment of COVID-19.
Patrick S Fier, Yingju Xu, Marc Poirier, Gilmar Brito, Michelle Zheng, Lushi Tan, Anthony Diaz-Santana

Org Process Res Dev· December 2021

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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties.
Petr Vachal, Joseph L Duffy, Louis-Charles Campeau, Rupesh P Amin, Kaushik Mitra, Lushi Tan

J Med Chem· September 2021

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Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods.
Artis Klapars, John Y L Chung, John Limanto, Ralph Calabria, Louis-Charles Campeau, Lushi Tan, Susan L Zultanski

Chem Sci· July 2021

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Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine.
Carmela Molinaro, Eric M Phillips, Bangping Xiang, Erika Milczek, Michael Shevlin, Lushi Tan

J Org Chem· June 2019

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Highly Diastereoselective Synthesis of a HCV NS5B Nucleoside Polymerase Inhibitor.
Yong-Li Zhong, Ed Cleator, Zhijian Liu, Jianguo Yin, William J Morris, Lushi Tan

J Org Chem· April 2019

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A Next Generation Synthesis of BACE1 Inhibitor Verubecestat (MK-8931).
David A Thaisrivongs, William J Morris, Lushi Tan, Zhiguo J Song, Thomas W Lyons

Org Lett· March 2018

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Development of a stereoselective and scalable process for the preparation of a methylcyclobutanol-pyridyl ether.
Jeffrey T Kuethe, Kallol Basu, Robert K Orr, Eric Ashley, Marc Poirier, Lushi Tan

Bioorg Med Chem· February 2018

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Asymmetric Formal Synthesis of the Long-Acting DPP-4 Inhibitor Omarigliptin.
Feng Peng, Yonggang Chen, Cheng-Yi Chen, Peter G Dormer, Amude Kassim, Lushi Tan

J Org Chem· September 2017

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Enantioselective Synthesis of 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) via Enzymatic Desymmetrization.
Mark McLaughlin, Jongrock Kong, Kevin M Belyk, Billy Chen, Andrew W Gibson, Lushi Tan

Org Lett· February 2017

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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.
Alan M Hyde, Zhijian Liu, Birgit Kosjek, Lushi Tan, Artis Klapars

Org Lett· November 2016

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Iridium(III)-Catalyzed Regioselective C7-Amination of N-Pivaloylindoles with Sulfonoazides.
Lanting Xu, Lushi Tan, Dawei Ma

J Org Chem· November 2016

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Synthesis of Verubecestat, a BACE1 Inhibitor for the Treatment of Alzheimer's Disease.
David A Thaisrivongs, Steven P Miller, Carmela Molinaro, Qinghao Chen, Zhiguo J Song, Lushi Tan

Org Lett· November 2016

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Rhodium-Catalyzed Regioselective C7-Functionalization of N-Pivaloylindoles.
Lanting Xu, Chao Zhang, Yupeng He, Lushi Tan, Dawei Ma

Angew Chem Int Ed Engl· January 2016

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Promotion of a Ti-Mediated Mannich Reaction by a Proton Source.
John Limanto, Naoki Yoshikawa, Robert A Reamer, Lushi Tan, Andrew Brunskill

J Org Chem· January 2016

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Synthesis of bis-macrocyclic HCV protease inhibitor MK-6325 via intramolecular sp²-sp³ Suzuki-Miyaura coupling and ring closing metathesis.
Hongmei Li, Jeremy P Scott, Cheng-yi Chen, Michel Journet, Kevin Belyk, Lushi Tan

Org Lett· March 2015

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Dynamic kinetic resolution: asymmetric transfer hydrogenation of alpha-alkyl-substituted beta-ketoamides.
John Limanto, Shane W Krska, Benjamin T Dorner, Enrique Vazquez, Naoki Yoshikawa, Lushi Tan

Org Lett· February 2010

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Catalytic enantioselective hydrogenation of N-alkoxycarbonyl hydrazones: a practical synthesis of chiral hydrazines.
Naoki Yoshikawa, Lushi Tan, J Christopher McWilliams, Deepa Ramasamy, Ruth Sheppard

Org Lett· January 2010

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An efficient and scalable synthesis of substituted phenanthrenequinones by intramolecular Friedel-Crafts reaction of imidazolides.
Naoki Yoshikawa, Austin Doyle, Lushi Tan, Jerry A Murry, Atsushi Akao

Org Lett· October 2007

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Stereoselective syntheses of highly functionalized bicyclo[3.1.0]hexanes: a general methodology for the synthesis of potent and selective mGluR2/3 agonists.
Lushi Tan, Nobuyoshi Yasuda, Naoki Yoshikawa, Frederick W Hartner, Kan Kaung Eng

J Org Chem· September 2005

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Practical asymmetric synthesis of a potent PDE4 inhibitor via stereoselective enolate alkylation of a chiral aryl-heteroaryl secondary tosylate.
Paul D O'Shea, Cheng-yi Chen, Weirong Chen, Philippe Dagneau, Lisa F Frey, Lushi Tan

J Org Chem· April 2005

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Methods for the synthesis of 5,6,7,8-tetrahydro-1,8-naphthyridine fragments for alphaVbeta3 integrin antagonists.
Frederick W Hartner, Yi Hsiao, Kan K Eng, Nelo R Rivera, Michael Palucki, Lushi Tan

J Org Chem· December 2004

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