Publications by authors named "Birgit Wilding"

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Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRAS.
Ludovica S Sirocchi, Maximilian Scharnweber, Sarah Oberndorfer, Gabriella Siszler, Krzysztof M Zak, Birgit Wilding

J Am Chem Soc· May 2025

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Zongertinib (BI 1810631), an Irreversible HER2 TKI, Spares EGFR Signaling and Improves Therapeutic Response in Preclinical Models and Patients with HER2-Driven Cancers.
Birgit Wilding, Lydia Woelflingseder, Anke Baum, Krzysztof Chylinski, Gintautas Vainorius

Cancer Discov· January 2025

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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
A Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, Angela Hayes, Loredana Pellegrino, Birgit Wilding

J Med Chem· April 2023

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Discovery of potent and selective HER2 inhibitors with efficacy against HER2 exon 20 insertion-driven tumors, which preserve wild-type EGFR signaling.
Birgit Wilding, Dirk Scharn, Dietrich Böse, Anke Baum, Valeria Santoro

Nat Cancer· July 2022

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Chemoenzymatic one-pot reaction from carboxylic acid to nitrile oxime.
Melissa Horvat, Victoria Weilch, Robert Rädisch, Sebastian Hecko, Astrid Schiefer, Birgit Wilding

Catal Sci Technol· January 2022

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Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Birgit Wilding, A Elisa Pasqua, Nicola E A Chessum, Olivier A Pierrat, Tamas Hahner

Bioorg Med Chem Lett· June 2021

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Privileged Structures and Polypharmacology within and between Protein Families.
Joshua Meyers, Nicola E A Chessum, Salyha Ali, N Yi Mok, Birgit Wilding

ACS Med Chem Lett· December 2018

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
Nicola E A Chessum, Swee Y Sharp, John J Caldwell, A Elisa Pasqua, Birgit Wilding

J Med Chem· February 2018

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
Matthew D Cheeseman, Nicola E A Chessum, Carl S Rye, A Elisa Pasqua, Michael J Tucker, Birgit Wilding

J Med Chem· January 2017

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Kinetic Analysis and Probing with Substrate Analogues of the Reaction Pathway of the Nitrile Reductase QueF from Escherichia coli.
Jihye Jung, Tibor Czabany, Birgit Wilding, Norbert Klempier, Bernd Nidetzky

J Biol Chem· December 2016

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The Nitrile-Forming Enzyme 7-Cyano-7-Deazaguanine Synthase from Geobacillus kaustophilus: A Reverse Nitrilase?
Margit Winkler, Katharina Dokulil, Hansjörg Weber, Tea Pavkov-Keller, Birgit Wilding

Chembiochem· November 2015

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An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain.
Birgit Wilding, Alicja B Veselá, Justin J B Perry, Gary W Black, Meng Zhang

Org Biomol Chem· July 2015

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Targeting the substrate binding site of E. coli nitrile reductase QueF by modeling, substrate and enzyme engineering.
Birgit Wilding, Margit Winkler, Barbara Petschacher, Regina Kratzer, Sigrid Egger

Chemistry· May 2013

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