Publications by authors named "Matthew D Cheeseman"

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Determination of Ligand-Binding Affinity () Using Transverse Relaxation Rate () in the Ligand-Observed H NMR Experiment and Applications to Fragment-Based Drug Discovery.
Manjuan Liu, Amin Mirza, P Craig McAndrew, Arjun Thapaliya, Olivier A Pierrat, Matthew D Cheeseman

J Med Chem· August 2023

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HSF1 Pathway Inhibitor Clinical Candidate (CCT361814/NXP800) Developed from a Phenotypic Screen as a Potential Treatment for Refractory Ovarian Cancer and Other Malignancies.
A Elisa Pasqua, Swee Y Sharp, Nicola E A Chessum, Angela Hayes, Loredana Pellegrino, Matthew D Cheeseman

J Med Chem· April 2023

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Investigating the phosphinic acid tripeptide mimetic DG013A as a tool compound inhibitor of the M1-aminopeptidase ERAP1.
Birgit Wilding, A Elisa Pasqua, Nicola E A Chessum, Olivier A Pierrat, Tamas Hahner, Matthew D Cheeseman

Bioorg Med Chem Lett· June 2021

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Kinetic Optimization of Lysine-Targeting Covalent Inhibitors of HSP72.
Jonathan Pettinger, Michael Carter, Keith Jones, Matthew D Cheeseman

J Med Chem· December 2019

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Privileged Structures and Polypharmacology within and between Protein Families.
Joshua Meyers, Nicola E A Chessum, Salyha Ali, N Yi Mok, Birgit Wilding, Matthew D Cheeseman

ACS Med Chem Lett· December 2018

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Demonstrating In-Cell Target Engagement Using a Pirin Protein Degradation Probe (CCT367766).
Nicola E A Chessum, Swee Y Sharp, John J Caldwell, A Elisa Pasqua, Birgit Wilding, Matthew D Cheeseman

J Med Chem· February 2018

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Lysine-Targeting Covalent Inhibitors.
Jonathan Pettinger, Keith Jones, Matthew D Cheeseman

Angew Chem Int Ed Engl· November 2017

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Targeting secondary protein complexes in drug discovery: studying the druggability and chemical biology of the HSP70/BAG1 complex.
Lindsay E Evans, Keith Jones, Matthew D Cheeseman

Chem Commun (Camb)· May 2017

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An Irreversible Inhibitor of HSP72 that Unexpectedly Targets Lysine-56.
Jonathan Pettinger, Yann-Vaï Le Bihan, Marcella Widya, Rob L M van Montfort, Keith Jones, Matthew D Cheeseman

Angew Chem Int Ed Engl· March 2017

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Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen.
Matthew D Cheeseman, Nicola E A Chessum, Carl S Rye, A Elisa Pasqua, Michael J Tucker

J Med Chem· January 2017

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A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
Alan M Jones, Isaac M Westwood, James D Osborne, Thomas P Matthews, Matthew D Cheeseman

Sci Rep· October 2016

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Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the heat shock factor 1 (HSF1) stress pathway and CDK9.
Carl S Rye, Nicola E A Chessum, Scott Lamont, Kurt G Pike, Paul Faulder, Matthew D Cheeseman

Medchemcomm· August 2016

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Investigating Apoptozole as a Chemical Probe for HSP70 Inhibition.
Lindsay E Evans, Matthew D Cheeseman, Norhakim Yahya, Keith Jones

PLoS One· July 2016

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Exploiting Protein Conformational Change to Optimize Adenosine-Derived Inhibitors of HSP70.
Matthew D Cheeseman, Isaac M Westwood, Olivier Barbeau, Martin Rowlands, Sarah Dobson

J Med Chem· May 2016

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Targeting the PPM1D phenotype; 2,4-bisarylthiazoles cause highly selective apoptosis in PPM1D amplified cell-lines.
Matthew D Cheeseman, Amir Faisal, Sydonia Rayter, Olivier R Barbeau, Andrew Kalusa

Bioorg Med Chem Lett· August 2014

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N-N bond-forming cyclization for the one-pot synthesis of N-aryl[3,4-d]pyrazolopyrimidines.
Lindsay E Evans, Matthew D Cheeseman, Keith Jones

Org Lett· July 2012

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Synthesis of (+)-DGDP and (-)-7-epialexine.
Timothy J Donohoe, Matthew D Cheeseman, Timothy J C O'Riordan, Jessica A Kershaw

Org Biomol Chem· November 2008

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Flexible strategy for the synthesis of pyrrolizidine alkaloids.
Timothy J Donohoe, Rhian E Thomas, Matthew D Cheeseman, Caroline L Rigby, Gurdip Bhalay

Org Lett· August 2008

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