Publications by authors named "Blake Rowe"

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Unique challenges required reassessment and alterations to critical reagents to rescue a neutralizing antibody assay.
Blake A Rowe, Katie Medina-Carle, Keguan Chen, Kimberly J Reese, Kenneth M McCarthy

Bioanalysis· September 2024

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MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.
Gregory M Dillon, Laura S Lubbers, Mitchell T Ferguson, Julie Z Lao, Ruey-Ruey C Huang, Blake A Rowe

Behav Pharmacol· April 2011

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PISA, a novel pharmacodynamic assay for assessing poly(ADP-ribose) polymerase (PARP) activity in situ.
Laura S Lubbers, Blake A Rowe, Lisa M Hodge, Susan E Browne, Richard Gundersdorf

J Pharmacol Toxicol Methods· December 2010

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Synthesis and evaluation of a new series of Neuropeptide S receptor antagonists.
Jeffrey Y Melamed, Amy E Zartman, Nathan R Kett, Anthony L Gotter, Victor N Uebele, Blake A Rowe

Bioorg Med Chem Lett· August 2010

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Transposition of three amino acids transforms the human metabotropic glutamate receptor (mGluR)-3-positive allosteric modulation site to mGluR2, and additional characterization of the mGluR2-positive allosteric modulation site.
Blake A Rowe, Hervé Schaffhauser, Sylvia Morales, Laura S Lubbers, Celine Bonnefous

J Pharmacol Exp Ther· July 2008

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Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
Céline Bonnefous, Jean-Michel Vernier, John H Hutchinson, Michael F Gardner, Merryl Cramer, Blake A Rowe

Bioorg Med Chem Lett· October 2005

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Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): efficacy in an animal model for schizophrenia.
Steven P Govek, Celine Bonnefous, John H Hutchinson, Theodore Kamenecka, Jeffrey McQuiston, Blake A Rowe

Bioorg Med Chem Lett· September 2005

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3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).
Rowena V Cube, Jean-Michel Vernier, John H Hutchinson, Michael F Gardner, Joyce K James, Blake A Rowe

Bioorg Med Chem Lett· May 2005

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 3: Identification and biological activity of indanone containing mGlu2 receptor potentiators.
Anthony B Pinkerton, Rowena V Cube, John H Hutchinson, Joyce K James, Michael F Gardner, Blake A Rowe

Bioorg Med Chem Lett· March 2005

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Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897.
Jeffery J Anderson, Greg Holtz, Patricia P Baskin, Mary Turner, Blake Rowe

Biochem Pharmacol· February 2005

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators.
Anthony B Pinkerton, Rowena V Cube, John H Hutchinson, Joyce K James, Michael F Gardner, Blake A Rowe

Bioorg Med Chem Lett· December 2004

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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 1: Identification and synthesis of phenyl-tetrazolyl acetophenones.
Anthony B Pinkerton, Rowena V Cube, John H Hutchinson, Blake A Rowe, Hervé Schaffhauser

Bioorg Med Chem Lett· November 2004

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Pyrimidine methyl anilines: selective potentiators for the metabotropic glutamate 2 receptor.
Essa Hu, Peter C Chua, Lida Tehrani, Johnny Y Nagasawa, Anthony B Pinkerton, Blake A Rowe

Bioorg Med Chem Lett· October 2004

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Phenyl-tetrazolyl acetophenones: discovery of positive allosteric potentiatiors for the metabotropic glutamate 2 receptor.
Anthony B Pinkerton, Jean-Michel Vernier, Hervé Schaffhauser, Blake A Rowe, Una C Campbell

J Med Chem· August 2004

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A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain.
Julie A O'Brien, Wei Lemaire, Marion Wittmann, Marlene A Jacobson, Sookhee N Ha, Blake Rowe

J Pharmacol Exp Ther· May 2004

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Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2.
Hervé Schaffhauser, Blake A Rowe, Sylvia Morales, Laura E Chavez-Noriega, Ruoyuan Yin

Mol Pharmacol· October 2003

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Group II mGlu receptor activation suppresses norepinephrine release in the ventral hippocampus and locomotor responses to acute ketamine challenge.
Daniel S Lorrain, Hervé Schaffhauser, Una C Campbell, Christopher S Baccei, Lucia D Correa, Blake Rowe

Neuropsychopharmacology· September 2003

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[3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization.
Jeffery J Anderson, Sara P Rao, Blake Rowe, Darlene R Giracello, Greg Holtz

J Pharmacol Exp Ther· December 2002

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