Publications by authors named "Merryl Cramer"

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CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity.
Joyce James, Bruce Ruggeri, Robert C Armstrong, Martin W Rowbottom, Susan Jones-Bolin, Merryl D Cramer

Mol Cancer Ther· April 2012

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Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
Martin W Rowbottom, Raffaella Faraoni, Qi Chao, Brian T Campbell, Andiliy G Lai, Merryl D Cramer

J Med Chem· February 2012

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Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors.
Sunny Abraham, Michael J Hadd, Lan Tran, Troy Vickers, Janice Sindac, Merryl D Cramer

Bioorg Med Chem Lett· September 2011

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4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Mark W Holladay, Brian T Campbell, Martin W Rowbottom, Qi Chao, Kelly G Sprankle, Merryl D Cramer

Bioorg Med Chem Lett· September 2011

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Identification of N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea dihydrochloride (AC220), a uniquely potent, selective, and efficacious FMS-like tyrosine kinase-3 (FLT3) inhibitor.
Qi Chao, Kelly G Sprankle, Robert M Grotzfeld, Andiliy G Lai, Todd A Carter, Merryl D Cramer

J Med Chem· December 2009

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AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML).
Patrick P Zarrinkar, Ruwanthi N Gunawardane, Merryl D Cramer, Michael F Gardner, Daniel Brigham

Blood· October 2009

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In vitro metabolic studies on the selective metabotropic glutamate receptor sub-type 5 (mGluR5) antagonist 3-[(2-methyl-1,3-thiazol-4-yl) ethynyl]-pyridine (MTEP).
Mitchell D Green, Xiaoqing Yang, Merryl Cramer, Christopher D King

Neurosci Lett· January 2006

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3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists.
Lida R Tehrani, Nicholas D Smith, Dehua Huang, Steve F Poon, Jeffrey R Roppe, Merryl Cramer

Bioorg Med Chem Lett· November 2005

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Biphenyl-indanones: allosteric potentiators of the metabotropic glutamate subtype 2 receptor.
Céline Bonnefous, Jean-Michel Vernier, John H Hutchinson, Michael F Gardner, Merryl Cramer

Bioorg Med Chem Lett· October 2005

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Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists.
Peter C Chua, Johnny Y Nagasawa, Leo S Bleicher, Benito Munoz, Edwin J Schweiger, Merryl Cramer

Bioorg Med Chem Lett· October 2005

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Metabolism and disposition of a potent group II metabotropic glutamate receptor agonist, in rats, dogs, and monkeys.
Joyce K James, Masato Nakamura, Atsuro Nakazato, Kanyin E Zhang, Merryl Cramer

Drug Metab Dispos· September 2005

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Influence of acid surrogates toward potency of VLA-4 antagonist.
Shankar Venkatraman, Jongwon Lim, Merryl Cramer, Michael F Gardner, Joyce James

Bioorg Med Chem Lett· September 2005

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Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.
Nicholas D Smith, Thomas S Reger, Joseph Payne, Jasmine Zunic, Dan Lorrain, Merryl Cramer

Bioorg Med Chem Lett· July 2005

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2-(2-[3-(pyridin-3-yloxy)phenyl]-2H-tetrazol-5-yl) pyridine: a highly potent, orally active, metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
Dehua Huang, Steve F Poon, Deborah F Chapman, Janice Chung, Merryl Cramer

Bioorg Med Chem Lett· November 2004

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3-[3-Fluoro-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)phenyl]-4-methylpyridine: a highly potent and orally bioavailable metabotropic glutamate subtype 5 (mGlu5) receptor antagonist.
Steve F Poon, Brian W Eastman, Deborah F Chapman, Janice Chung, Merryl Cramer

Bioorg Med Chem Lett· November 2004

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Discovery of highly potent, selective, orally bioavailable, metabotropic glutamate subtype 5 (mGlu5) receptor antagonists devoid of cytochrome P450 1A2 inhibitory activity.
Nicholas D Smith, Steve F Poon, Dehua Huang, Mitchell Green, Christopher King, Merryl Cramer

Bioorg Med Chem Lett· November 2004

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5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity.
Jeffrey R Roppe, Bowei Wang, Dehua Huang, Lida Tehrani, Theodore Kamenecka, Merryl Cramer

Bioorg Med Chem Lett· August 2004

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Synthesis and biological evaluation of 6-aryl-6H-pyrrolo[3,4-d]pyridazine derivatives: high-affinity ligands to the alpha 2 delta subunit of voltage gated calcium channels.
Brian A Stearns, Naomi Anker, Jeannie M Arruda, Brian T Campbell, Chixu Chen, Merryl Cramer

Bioorg Med Chem Lett· March 2004

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