Publications by authors named "Martin W Rowbottom"

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Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2).
Martin W Rowbottom, Gretchen Bain, Imelda Calderon, Taylor Lasof, David Lonergan

J Med Chem· May 2017

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Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.
John H Hutchinson, Martin W Rowbottom, David Lonergan, Janice Darlington, Pat Prodanovich

ACS Med Chem Lett· April 2017

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CEP-32496: a novel orally active BRAF(V600E) inhibitor with selective cellular and in vivo antitumor activity.
Joyce James, Bruce Ruggeri, Robert C Armstrong, Martin W Rowbottom, Susan Jones-Bolin

Mol Cancer Ther· April 2012

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Identification of 1-(3-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea hydrochloride (CEP-32496), a highly potent and orally efficacious inhibitor of V-RAF murine sarcoma viral oncogene homologue B1 (BRAF) V600E.
Martin W Rowbottom, Raffaella Faraoni, Qi Chao, Brian T Campbell, Andiliy G Lai

J Med Chem· February 2012

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4-Quinazolinyloxy-diaryl ureas as novel BRAFV600E inhibitors.
Mark W Holladay, Brian T Campbell, Martin W Rowbottom, Qi Chao, Kelly G Sprankle

Bioorg Med Chem Lett· September 2011

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Thienopyrimidinone bis-aminopyrrolidine ureas as potent melanin-concentrating hormone receptor-1 (MCH-R1) antagonists.
Mingzhu Zhang, Junko Tamiya, Linh Nguyen, Martin W Rowbottom, Brian Dyck

Bioorg Med Chem Lett· May 2007

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Synthesis and structure-activity relationships of spirohydantoin-derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Martin W Rowbottom, Troy D Vickers, Junko Tamiya, Mingzhu Zhang, Brian Dyck

Bioorg Med Chem Lett· April 2007

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Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1.
Martin W Rowbottom, Troy D Vickers, Brian Dyck, Jonathan Grey, Junko Tamiya

Bioorg Med Chem Lett· September 2006

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Synthesis and structure-activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 2.
Sarah Hudson, Mehrak Kiankarimi, Martin W Rowbottom, Troy D Vickers, Dongpei Wu

Bioorg Med Chem Lett· September 2006

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A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties.
Brian Dyck, Stacy Markison, Liren Zhao, Junko Tamiya, Jonathan Grey, Martin W Rowbottom

J Med Chem· June 2006

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Structure-activity relationships of 1,3,5-triazine-2,4,6-triones as human gonadotropin-releasing hormone receptor antagonists.
Zhiqiang Guo, Dongpei Wu, Yun-Fei Zhu, Fabio C Tucci, Collin F Regan, Martin W Rowbottom

Bioorg Med Chem Lett· August 2005

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Synthesis and structure-activity relationships of biarylcarboxamide bis-aminopyrrolidine urea derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1).
Martin W Rowbottom, Troy D Vickers, Brian Dyck, Junko Tamiya, Mingzhu Zhang

Bioorg Med Chem Lett· July 2005

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Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers.
Zhiqiang Guo, Yongsheng Chen, Charles Q Huang, Timothy D Gross, Joseph Pontillo, Martin W Rowbottom

Bioorg Med Chem Lett· May 2005

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Bis(aminopyrrolidine)-derived ureas (APUs) as potent MCH1 receptor antagonists.
Jonathan Grey, Brian Dyck, Martin W Rowbottom, Junko Tamiya, Troy D Vickers

Bioorg Med Chem Lett· February 2005

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3-[(2R)-Amino-2-phenylethyl]-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)- 6-methylpyrimidin-2,4-dione (NBI 42902) as a potent and orally active antagonist of the human gonadotropin-releasing hormone receptor. Design, synthesis, and in vitro and in vivo characterization.
Fabio C Tucci, Yun-Fei Zhu, R Scott Struthers, Zhiqiang Guo, Timothy D Gross, Martin W Rowbottom

J Med Chem· February 2005

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Synthesis and structure-activity relationships of uracil derived human GnRH receptor antagonists: (R)-3-[2-(2-amino)phenethyl]-1-(2,6-difluorobenzyl)-6-methyluracils containing a substituted thiophene or thiazole at C-5.
Martin W Rowbottom, Fabio C Tucci, Patrick J Connors, Timothy D Gross, Yun-Fei Zhu

Bioorg Med Chem Lett· October 2004

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3-(2-aminoalkyl)-1-(2,6-difluorobenzyl)-5- (2-fluoro-3-methoxyphenyl)-6-methyl-uracils as orally bioavailable antagonists of the human gonadotropin releasing hormone receptor.
Fabio C Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D Gross, Patrick J Connors, Martin W Rowbottom

J Med Chem· July 2004

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Synthesis and structure-activity relationships of (R)-1-alkyl-3-[2-(2-amino)phenethyl]-5-(2-fluorophenyl)-6-methyluracils as human GnRH receptor antagonists.
Martin W Rowbottom, Fabio C Tucci, Yun-Fei Zhu, Zhiqiang Guo, Timothy D Gross

Bioorg Med Chem Lett· May 2004

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Synthesis and structure-activity relationships of 1-arylmethyl-5-aryl-6-methyluracils as potent gonadotropin-releasing hormone receptor antagonists.
Zhiqiang Guo, Yun-Fei Zhu, Timothy D Gross, Fabio C Tucci, Yinghong Gao, Martin W Rowbottom

J Med Chem· February 2004

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