Publications by authors named "Pat Prodanovich"

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Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX.
John H Hutchinson, Martin W Rowbottom, David Lonergan, Janice Darlington, Pat Prodanovich

ACS Med Chem Lett· April 2017

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Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
Adam J Stein, Gretchen Bain, Pat Prodanovich, Angelina M Santini, Janice Darlington

Mol Pharmacol· December 2015

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5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Nicholas S Stock, Gretchen Bain, Jasmine Zunic, Yiwei Li, Jeannie Ziff, Pat Prodanovich

J Med Chem· December 2011

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Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis.
Jill M Scott, Christopher Baccei, Gretchen Bain, Alex Broadhead, Jilly F Evans, Pat Prodanovich

Bioorg Med Chem Lett· November 2011

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Pharmacology of AM211, a potent and selective prostaglandin D2 receptor type 2 antagonist that is active in animal models of allergic inflammation.
Gretchen Bain, Daniel S Lorrain, Karin J Stebbins, Alex R Broadhead, Angelina M Santini, Pat Prodanovich

J Pharmacol Exp Ther· July 2011

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Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Nicholas Stock, Deborah Volkots, Karin Stebbins, Alex Broadhead, Brian Stearns, Pat Prodanovich

Bioorg Med Chem Lett· February 2011

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5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Nicholas Stock, Christopher Baccei, Gretchen Bain, Charles Chapman, Lucia Correa, Pat Prodanovich

Bioorg Med Chem Lett· August 2010

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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Nicholas Stock, Christopher Baccei, Gretchen Bain, Alex Broadhead, Charles Chapman, Pat Prodanovich

Bioorg Med Chem Lett· January 2010

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Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.
Daniel S Lorrain, Gretchen Bain, Lucia D Correa, Charles Chapman, Alex R Broadhead, Pat Prodanovich

J Pharmacol Exp Ther· December 2009

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5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).
John H Hutchinson, Yiwei Li, Jeannie M Arruda, Christopher Baccei, Gretchen Bain, Pat Prodanovich

J Med Chem· October 2009

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Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Brian A Stearns, Christopher Baccei, Gretchen Bain, Alex Broadhead, Ryan C Clark, Pat Prodanovich

Bioorg Med Chem Lett· August 2009

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Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia.
Rebecca L Cole, Sandra M Lechner, Mark E Williams, Pat Prodanovich, Leo Bleicher

J Comp Neurol· October 2005

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