Publications by authors named "Nicholas Stock"

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Discovery of potent and selective PPARα/δ dual antagonists and initial biological studies.
Jason D Jacintho, Christopher S Baccei, Yalda Bravo, Alex Broadhead, Austin Chen, Nicholas S Stock

Bioorg Med Chem Lett· February 2019

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In vitro and in vivo pharmacology of NXT629, a novel and selective PPARα antagonist.
Karin J Stebbins, Alex R Broadhead, Geraldine Cabrera, Lucia D Correa, Davorka Messmer, Nicholas S Stock

Eur J Pharmacol· August 2017

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A Selective Novel Peroxisome Proliferator-Activated Receptor (PPAR)-α Antagonist Induces Apoptosis and Inhibits Proliferation of CLL Cells In Vitro and In Vivo.
Davorka Messmer, Kymmy Lorrain, Karin Stebbins, Yalda Bravo, Nicholas Stock

Mol Med· June 2015

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Identification of the first potent, selective and bioavailable PPARα antagonist.
Yalda Bravo, Christopher S Baccei, Alex Broadhead, Richard Bundey, Austin Chen, Nicholas Stock

Bioorg Med Chem Lett· May 2014

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Thirty years of disparities intervention research: what are we doing to close racial and ethnic gaps in health care?
Amanda R Clarke, Anna P Goddu, Robert S Nocon, Nicholas W Stock, Linda C Chyr

Med Care· November 2013

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Pharmacodynamics, pharmacokinetics and safety of GSK2190915, a novel oral anti-inflammatory 5-lipoxygenase-activating protein inhibitor.
Gretchen Bain, Christopher D King, Kevin Schaab, Melissa Rewolinski, Virginia Norris, Nicholas Stock

Br J Clin Pharmacol· March 2013

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5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Nicholas S Stock, Gretchen Bain, Jasmine Zunic, Yiwei Li, Jeannie Ziff

J Med Chem· December 2011

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Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Nicholas Stock, Deborah Volkots, Karin Stebbins, Alex Broadhead, Brian Stearns

Bioorg Med Chem Lett· February 2011

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Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.
Daniel S Lorrain, Gretchen Bain, Lucia D Correa, Charles Chapman, Alex R Broadhead, Nicholas S Stock

Eur J Pharmacol· August 2010

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5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Nicholas Stock, Christopher Baccei, Gretchen Bain, Charles Chapman, Lucia Correa

Bioorg Med Chem Lett· August 2010

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Pharmacological blockade of the DP2 receptor inhibits cigarette smoke-induced inflammation, mucus cell metaplasia, and epithelial hyperplasia in the mouse lung.
Karin J Stebbins, Alex R Broadhead, Christopher S Baccei, Jill M Scott, Yen P Truong, Nicholas S Stock

J Pharmacol Exp Ther· March 2010

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Heterocycle-substituted proline dipeptides as potent VLA-4 antagonists.
Thomas S Reger, Jasmine Zunic, Nicholas Stock, Bowei Wang, Nicholas D Smith

Bioorg Med Chem Lett· February 2010

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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Nicholas Stock, Christopher Baccei, Gretchen Bain, Alex Broadhead, Charles Chapman

Bioorg Med Chem Lett· January 2010

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A novel 5-lipoxygenase-activating protein inhibitor, AM679, reduces inflammation in the respiratory syncytial virus-infected mouse eye.
Alla Musiyenko, Lucia Correa, Nicholas Stock, John H Hutchinson, Daniel S Lorrain

Clin Vaccine Immunol· November 2009

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Discovery of N-{N-[(3-cyanobenzene) sulfonyl]-4(R)-(3,3-difluoropiperidin-1-yl)-(l)-prolyl}-4-[(3',5'-dichloro-isonicotinoyl) amino]-(l)-phenylalanine (MK-0617), a highly potent and orally active VLA-4 antagonist.
Shankar Venkatraman, Alec D Lebsack, Kenneth Alves, Michael F Gardner, Joyce James, Nicholas Stock

Bioorg Med Chem Lett· October 2009

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5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).
John H Hutchinson, Yiwei Li, Jeannie M Arruda, Christopher Baccei, Gretchen Bain, Nicholas Stock

J Med Chem· October 2009

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Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis.
Brian A Stearns, Christopher Baccei, Gretchen Bain, Alex Broadhead, Ryan C Clark, Nicholas S Stock

Bioorg Med Chem Lett· August 2009

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The geminal dimethyl analogue of Flurbiprofen as a novel Abeta42 inhibitor and potential Alzheimer's disease modifying agent.
Nicholas Stock, Benito Munoz, Jonathan D J Wrigley, Mark S Shearman, Dirk Beher

Bioorg Med Chem Lett· April 2006

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Water soluble prodrug of a COX-2 selective inhibitor suitable for intravenous administration in models of cerebral ischemia.
Nicholas D Smith, Thomas S Reger, Joseph Payne, Jasmine Zunic, Dan Lorrain, Nicholas Stock

Bioorg Med Chem Lett· July 2005

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Novel approach to pro-drugs of lactones: water soluble imidate and ortho-ester derivatives of a furanone-based COX-2 selective inhibitor.
Steve F Poon, Nicholas Stock, Joseph E Payne, Angela R McGuire, Brian Stearns

Bioorg Med Chem Lett· May 2005

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Glucuronidation of carboxylic acid containing compounds by UDP-glucuronosyltransferase isoforms.
Kayo Sakaguchi, Mitchell Green, Nicholas Stock, Thomas S Reger, Jasmine Zunic

Arch Biochem Biophys· April 2004

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N-Acridin-9-yl-butane-1,4-diamine derivatives: high-affinity ligands of the alpha2delta subunit of voltage gated calcium channels.
Jongwon Lim, Nicholas Stock, Richard Pracitto, Julia K Boueres, Benito Munoz

Bioorg Med Chem Lett· April 2004

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