Publications by authors named "Charles Chapman"

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Stereoselective Synthesis and Biological Evaluation of C1-Epimeric and Desmethyl Monomeric Nuphar Analogues.
Hui Li, Timothy J Cooke, Alexander Korotkov, Charles W Chapman, Alan Eastman

J Org Chem· March 2017

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Enantioselective Formal Syntheses of 11 Nuphar Alkaloids and Discovery of Potent Apoptotic Monomeric Analogues.
Hui Li, Alexander Korotkov, Charles W Chapman, Alan Eastman, Jimmy Wu

Angew Chem Int Ed Engl· March 2016

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Total Syntheses and Biological Evaluation of Both Enantiomers of Several Hydroxylated Dimeric Nuphar Alkaloids.
Alexander Korotkov, Hui Li, Charles W Chapman, Haoran Xue, John B MacMillan

Angew Chem Int Ed Engl· September 2015

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5-Lipoxygenase-activating protein (FLAP) inhibitors. Part 4: development of 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid (AM803), a potent, oral, once daily FLAP inhibitor.
Nicholas S Stock, Gretchen Bain, Jasmine Zunic, Yiwei Li, Jeannie Ziff, Charles Chapman

J Med Chem· December 2011

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Sodium [2'-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4'-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): a potent, selective prostaglandin D2 receptor antagonist.
Nicholas Stock, Deborah Volkots, Karin Stebbins, Alex Broadhead, Brian Stearns, Charles Chapman

Bioorg Med Chem Lett· February 2011

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Pharmacology of AM803, a novel selective five-lipoxygenase-activating protein (FLAP) inhibitor in rodent models of acute inflammation.
Daniel S Lorrain, Gretchen Bain, Lucia D Correa, Charles Chapman, Alex R Broadhead

Eur J Pharmacol· August 2010

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5-Lipoxygenase-activating protein inhibitors. Part 3: 3-{3-tert-Butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM643)-A potent FLAP inhibitor suitable for topical administration.
Nicholas Stock, Christopher Baccei, Gretchen Bain, Charles Chapman, Lucia Correa

Bioorg Med Chem Lett· August 2010

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5-Lipoxygenase-activating protein inhibitors. Part 2: 3-{5-((S)-1-Acetyl-2,3-dihydro-1H-indol-2-ylmethoxy)-3-tert-butylsulfanyl-1-[4-(5-methoxy-pyrimidin-2-yl)-benzyl]-1H-indol-2-yl}-2,2-dimethyl-propionic acid (AM679)--a potent FLAP inhibitor.
Nicholas Stock, Christopher Baccei, Gretchen Bain, Alex Broadhead, Charles Chapman

Bioorg Med Chem Lett· January 2010

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Pharmacological characterization of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103), a novel selective 5-lipoxygenase-activating protein inhibitor that reduces acute and chronic inflammation.
Daniel S Lorrain, Gretchen Bain, Lucia D Correa, Charles Chapman, Alex R Broadhead

J Pharmacol Exp Ther· December 2009

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5-lipoxygenase-activating protein inhibitors: development of 3-[3-tert-butylsulfanyl-1-[4-(6-methoxy-pyridin-3-yl)-benzyl]-5-(pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid (AM103).
John H Hutchinson, Yiwei Li, Jeannie M Arruda, Christopher Baccei, Gretchen Bain, Charles Chapman

J Med Chem· October 2009

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