Publications by authors named "Sandra M Lechner"

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Pharmacology and Mechanism of Action of Suzetrigine, a Potent and Selective Na1.8 Pain Signal Inhibitor for the Treatment of Moderate to Severe Pain.
Jeremiah D Osteen, Swapna Immani, Tim L Tapley, Tim Indersmitten, Nicole W Hurst, Sandra M Lechner

Pain Ther· April 2025

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Selective Inhibition of Na1.8 with VX-548 for Acute Pain.
Jim Jones, Darin J Correll, Sandra M Lechner, Ina Jazic, Xiaopeng Miao

N Engl J Med· August 2023

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N-[6-amino-2-(heteroaryl)pyrimidin-4-yl]acetamides as A2A receptor antagonists with improved drug like properties and in vivo efficacy.
Marion C Lanier, Manisha Moorjani, Zhiyong Luo, Yongsheng Chen, Emily Lin, Sandra M Lechner

J Med Chem· February 2009

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Drugability of extracellular targets: discovery of small molecule drugs targeting allosteric, functional, and subunit-selective sites on GPCRs and ion channels.
Dimitri E Grigoriadis, Samuel R J Hoare, Sandra M Lechner, Deborah H Slee, John A Williams

Neuropsychopharmacology· January 2009

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Lead optimization of 4-acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A adenosine receptor antagonists for the treatment of Parkinson's disease.
Xiaohu Zhang, John E Tellew, Zhiyong Luo, Manisha Moorjani, Emily Lin, Sandra M Lechner

J Med Chem· November 2008

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2,6-Diaryl-4-acylaminopyrimidines as potent and selective adenosine A(2A) antagonists with improved solubility and metabolic stability.
Manisha Moorjani, Zhiyong Luo, Emily Lin, Binh G Vong, Yongsheng Chen, Sandra M Lechner

Bioorg Med Chem Lett· October 2008

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Distribution of metabotropic glutamate 2 and 3 receptors in the rat forebrain: Implication in emotional responses and central disinhibition.
Guibao Gu, Daniel S Lorrain, Hongbing Wei, Rebecca L Cole, Xin Zhang, Sandra M Lechner

Brain Res· March 2008

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2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 1. Structure-activity relationships and optimization of heterocyclic substituents.
Deborah H Slee, Yongsheng Chen, Xiaohu Zhang, Manisha Moorjani, Marion C Lanier, Sandra M Lechner

J Med Chem· March 2008

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2-Amino-N-pyrimidin-4-ylacetamides as A2A receptor antagonists: 2. Reduction of hERG activity, observed species selectivity, and structure-activity relationships.
Deborah H Slee, Manisha Moorjani, Xiaohu Zhang, Emily Lin, Marion C Lanier, Sandra M Lechner

J Med Chem· March 2008

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Synthesis of N-pyrimidinyl-2-phenoxyacetamides as adenosine A2A receptor antagonists.
Xiaohu Zhang, Jaimie K Rueter, Yongsheng Chen, Manisha Moorjani, Marion C Lanier, Sandra M Lechner

Bioorg Med Chem Lett· March 2008

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Identification of novel, water-soluble, 2-amino-N-pyrimidin-4-yl acetamides as A2A receptor antagonists with in vivo efficacy.
Deborah H Slee, Xiaohu Zhang, Manisha Moorjani, Emily Lin, Marion C Lanier, Sandra M Lechner

J Med Chem· February 2008

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2,6-Diaryl-4-phenacylaminopyrimidines as potent and selective adenosine A(2A) antagonists with reduced hERG liability.
Manisha Moorjani, Xiaohu Zhang, Yongsheng Chen, Emily Lin, Jaimie K Rueter, Sandra M Lechner

Bioorg Med Chem Lett· February 2008

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A novel cell-based assay for G-protein-coupled receptor-mediated cyclic adenosine monophosphate response element binding protein phosphorylation.
Julie V Selkirk, Lisa M Nottebaum, Ian C Ford, Mark Santos, Siobhan Malany, Sandra M Lechner

J Biomol Screen· June 2006

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Gene expression analyses reveal molecular relationships among 20 regions of the human CNS.
Richard B Roth, Peter Hevezi, Jerry Lee, Dorian Willhite, Sandra M Lechner

Neurogenetics· May 2006

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Human class-I restricted T cell associated molecule is highly expressed in the cerebellum and is a marker for activated NKT and CD8+ T lymphocytes.
Genaro Patiño-Lopez, Peter Hevezi, Jerry Lee, Dorian Willhite, Gail M Verge, Sandra M Lechner

J Neuroimmunol· February 2006

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Glutamate-based therapeutic approaches: inhibitors of glycine transport.
Sandra M Lechner

Curr Opin Pharmacol· February 2006

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Differential distribution of voltage-gated calcium channel alpha-2 delta (alpha2delta) subunit mRNA-containing cells in the rat central nervous system and the dorsal root ganglia.
Rebecca L Cole, Sandra M Lechner, Mark E Williams, Pat Prodanovich, Leo Bleicher

J Comp Neurol· October 2005

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