Publications by authors named "Boreth Eam"

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Zotatifin, an eIF4A-Selective Inhibitor, Blocks Tumor Growth in Receptor Tyrosine Kinase Driven Tumors.
Adina Gerson-Gurwitz, Nathan P Young, Vikas K Goel, Boreth Eam, Craig R Stumpf

Front Oncol· November 2021

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1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.
Christian Nilewski, Theodore D Michels, Garrick K Packard, Alan X Xiang, Paul A Sprengeler, Boreth Eam

Bioorg Med Chem Lett· September 2021

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Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Peggy A Thompson, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen

Mol Cancer Ther· January 2021

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Strategic Diastereoselective C1 Functionalization in the Aza-Rocaglamide Scaffold toward Natural Product-Inspired eIF4A Inhibitors.
Christian Nilewski, Theodore D Michels, Alan X Xiang, Garrick K Packard, Paul A Sprengeler, Boreth Eam

Org Lett· August 2020

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
Justin T Ernst, Peggy A Thompson, Christian Nilewski, Paul A Sprengeler, Samuel Sperry, Boreth Eam

J Med Chem· June 2020

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Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
Siegfried H Reich, Paul A Sprengeler, Gary G Chiang, James R Appleman, Joan Chen, Boreth Eam

J Med Chem· April 2018

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Differential T cell responses to residual viral antigen prolong CD4+ T cell contraction following the resolution of infection.
Ichiro Misumi, Mehrdad Alirezaei, Boreth Eam, Maureen A Su, J Lindsay Whitton

J Immunol· December 2013

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Mice deficient in stem cell antigen-1 (Sca1, Ly-6A/E) develop normal primary and memory CD4+ and CD8+ T-cell responses to virus infection.
Jason K Whitmire, Boreth Eam, J Lindsay Whitton

Eur J Immunol· June 2009

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Increasing the CD4+ T cell precursor frequency leads to competition for IFN-gamma thereby degrading memory cell quantity and quality.
Jason K Whitmire, Nicola Benning, Boreth Eam, J Lindsay Whitton

J Immunol· May 2008

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Tentative T cells: memory cells are quick to respond, but slow to divide.
Jason K Whitmire, Boreth Eam, J Lindsay Whitton

PLoS Pathog· April 2008

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Myelin oligodendrocyte glycoprotein peptide-induced experimental allergic encephalomyelitis and T cell responses are unaffected by immunoproteasome deficiency.
Ricardo F Frausto, Stephen J Crocker, Boreth Eam, Jason K Whitmire, J Lindsay Whitton

J Neuroimmunol· December 2007

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Direct interferon-gamma signaling dramatically enhances CD4+ and CD8+ T cell memory.
Jason K Whitmire, Boreth Eam, Nicola Benning, J Lindsay Whitton

J Immunol· July 2007

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Vertical transmission of diverse microbes in the tropical sponge Corticium sp.
Koty H Sharp, Boreth Eam, D John Faulkner, Margo G Haygood

Appl Environ Microbiol· January 2007

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Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.
Jennifer L Johnson, Sandrine Pacquelet, William S Lane, Boreth Eam, Sergio D Catz

Traffic· August 2005

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