Publications by authors named "Samuel Sperry"

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1-Aminomethyl SAR in a novel series of flavagline-inspired eIF4A inhibitors: Effects of amine substitution on cell potency and in vitro PK properties.
Christian Nilewski, Theodore D Michels, Garrick K Packard, Alan X Xiang, Paul A Sprengeler, Samuel Sperry

Bioorg Med Chem Lett· September 2021

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Targeting Oncogene mRNA Translation in B-Cell Malignancies with eFT226, a Potent and Selective Inhibitor of eIF4A.
Peggy A Thompson, Boreth Eam, Nathan P Young, Sarah Fish, Joan Chen, Samuel Sperry

Mol Cancer Ther· January 2021

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Design of Development Candidate eFT226, a First in Class Inhibitor of Eukaryotic Initiation Factor 4A RNA Helicase.
Justin T Ernst, Peggy A Thompson, Christian Nilewski, Paul A Sprengeler, Samuel Sperry

J Med Chem· June 2020

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Structure-based Design of Pyridone-Aminal eFT508 Targeting Dysregulated Translation by Selective Mitogen-activated Protein Kinase Interacting Kinases 1 and 2 (MNK1/2) Inhibition.
Siegfried H Reich, Paul A Sprengeler, Gary G Chiang, James R Appleman, Joan Chen, Samuel Sperry

J Med Chem· April 2018

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Identification of novel HSP90α/β isoform selective inhibitors using structure-based drug design. demonstration of potential utility in treating CNS disorders such as Huntington's disease.
Justin T Ernst, Timothy Neubert, Michael Liu, Samuel Sperry, Harmon Zuccola

J Med Chem· April 2014

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