Publications by authors named "Brenda Pennypacker"

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Differing Effects of Parathyroid Hormone, Alendronate, and Odanacatib on Bone Formation and on the Mineralization Process in Intracortical and Endocortical Bone of Ovariectomized Rabbits.
Christina Vrahnas, Pascal R Buenzli, Thomas A Pearson, Brenda L Pennypacker, Mark J Tobin

Calcif Tissue Int· December 2018

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Cathepsin K inhibition preserves compressive load in lumbar vertebrae of osteoporotic monkeys.
Isabel D Colón-Bernal, Le T Duong, Brenda Pennypacker, James Henderson, Kenneth M Kozloff

Bone Rep· December 2018

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Odanacatib increases mineralized callus during fracture healing in a rabbit ulnar osteotomy model.
Brenda L Pennypacker, David Gilberto, Nicholas T Gatto, Rana Samadfam, Susan Y Smith

J Orthop Res· January 2016

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Alteration of Type I collagen microstructure induced by estrogen depletion can be prevented with drug treatment.
Meagan A Cauble, Edward Rothman, Kathleen Welch, Ming Fang, Le T Duong, Brenda L Pennypacker

Bonekey Rep· July 2015

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Identification of an anabolic selective androgen receptor modulator that actively induces death of androgen-independent prostate cancer cells.
Azriel Schmidt, Robert S Meissner, Michael A Gentile, Michael J Chisamore, Evan E Opas, Brenda Pennypacker

J Steroid Biochem Mol Biol· September 2014

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Inhibition of cathepsin K increases modeling-based bone formation, and improves cortical dimension and strength in adult ovariectomized monkeys.
Brenda L Pennypacker, Charles M Chen, Helen Zheng, Mei-Shu Shih, Mary Belfast

J Bone Miner Res· August 2014

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The bone resorption inhibitors odanacatib and alendronate affect post-osteoclastic events differently in ovariectomized rabbits.
Pia Rosgaard Jensen, Thomas Levin Andersen, Brenda L Pennypacker, Le T Duong, Jean-Marie Delaissé

Calcif Tissue Int· February 2014

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A supra-cellular model for coupling of bone resorption to formation during remodeling: lessons from two bone resorption inhibitors affecting bone formation differently.
Pia Rosgaard Jensen, Thomas Levin Andersen, Brenda L Pennypacker, Le T Duong, Lars H Engelholm

Biochem Biophys Res Commun· January 2014

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Cathepsin K inhibitors increase distal femoral bone mineral density in rapidly growing rabbits.
Brenda L Pennypacker, Renata M Oballa, Sonia Levesque, Donald B Kimmel, Le T Duong

BMC Musculoskelet Disord· December 2013

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Odanacatib reduces bone turnover and increases bone mass in the lumbar spine of skeletally mature ovariectomized rhesus monkeys.
Patricia J Masarachia, Brenda L Pennypacker, Maureen Pickarski, Kevin R Scott, Gregg A Wesolowski

J Bone Miner Res· March 2012

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Odanacatib treatment increases hip bone mass and cortical thickness by preserving endocortical bone formation and stimulating periosteal bone formation in the ovariectomized adult rhesus monkey.
Tara Cusick, Charles M Chen, Brenda L Pennypacker, Maureen Pickarski, Donald B Kimmel

J Bone Miner Res· March 2012

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Cathepsin K inhibitors prevent bone loss in estrogen-deficient rabbits.
Brenda L Pennypacker, Le T Duong, Tara E Cusick, Patricia J Masarachia, Michael A Gentile

J Bone Miner Res· February 2011

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Discovery of the selective androgen receptor modulator MK-0773 using a rational development strategy based on differential transcriptional requirements for androgenic anabolism versus reproductive physiology.
Azriel Schmidt, Donald B Kimmel, Chang Bai, Angela Scafonas, Sujane Rutledge, Brenda Pennypacker

J Biol Chem· May 2010

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A jugular bleeding technique in rabbits.
Elizabeth A Nelson, Gina L Keller, Thomas W Mitchell, Brenda Pennypacker, Patricia Rebbeck

Lab Anim (NY)· January 2010

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Identification of anabolic selective androgen receptor modulators with reduced activities in reproductive tissues and sebaceous glands.
Azriel Schmidt, Shun-Ichi Harada, Donald B Kimmel, Chang Bai, Fang Chen, Brenda Pennypacker

J Biol Chem· December 2009

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Androgenic induction of growth and differentiation in the rodent uterus involves the modulation of estrogen-regulated genetic pathways.
Pascale V Nantermet, Patricia Masarachia, Michael A Gentile, Brenda Pennypacker, Jian Xu

Endocrinology· February 2005

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Nonpeptide alphavbeta3 antagonists. Part 11: discovery and preclinical evaluation of potent alphavbeta3 antagonists for the prevention and treatment of osteoporosis.
Paul J Coleman, Karen M Brashear, Ben C Askew, John H Hutchinson, Carol A McVean, Brenda Pennypacker

J Med Chem· September 2004

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Nonpeptide alphavbeta3 antagonists. 8. In vitro and in vivo evaluation of a potent alphavbeta3 antagonist for the prevention and treatment of osteoporosis.
John H Hutchinson, Wasyl Halczenko, Karen M Brashear, Michael J Breslin, Paul J Coleman, Brenda Pennypacker

J Med Chem· October 2003

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