Publications by authors named "Brendon Ladd"

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STX-721, a Covalent EGFR/HER2 Exon 20 Inhibitor, Utilizes Exon 20-Mutant Dynamic Protein States and Achieves Unique Mutant Selectivity Across Human Cancer Models.
Raymond A Pagliarini, Jack A Henderson, Benjamin C Milgram, Deanna R Borrelli, Natasja Brooijmans, Brendon Ladd

Clin Cancer Res· July 2025

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Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer.
Benjamin C Milgram, Deanna R Borrelli, Natasja Brooijmans, Jack A Henderson, Brendan J Hilbert, Brendon Ladd

J Med Chem· February 2025

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STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.
Leonard Buckbinder, David J St Jean, Trang Tieu, Brendon Ladd, Brendan Hilbert

Cancer Discov· November 2023

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A Method for Determining the Kinetics of Small-Molecule-Induced Ubiquitination.
Ellen F Vieux, Roman V Agafonov, Lydia Emerson, Marta Isasa, Richard W Deibler, Brendon Ladd

SLAS Discov· April 2021

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Acquired savolitinib resistance in non-small cell lung cancer arises via multiple mechanisms that converge on MET-independent mTOR and MYC activation.
Ryan E Henry, Evan R Barry, Lillian Castriotta, Brendon Ladd, Aleksandra Markovets

Oncotarget· September 2016

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Effective combination therapies in preclinical endocrine resistant breast cancer models harboring ER mutations.
Brendon Ladd, Anne Marie Mazzola, Teeru Bihani, Zhongwu Lai, James Bradford

Oncotarget· August 2016

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AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models.
Hazel M Weir, Robert H Bradbury, Mandy Lawson, Alfred A Rabow, David Buttar, Brendon Ladd

Cancer Res· June 2016

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Tumors with AKT1E17K Mutations Are Rational Targets for Single Agent or Combination Therapy with AKT Inhibitors.
Barry R Davies, Nin Guan, Armelle Logie, Claire Crafter, Lyndsey Hanson, Brendon Ladd

Mol Cancer Ther· November 2015

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Hypoxia drives transient site-specific copy gain and drug-resistant gene expression.
Joshua C Black, Elnaz Atabakhsh, Jaegil Kim, Kelly M Biette, Capucine Van Rechem, Brendon Ladd

Genes Dev· May 2015

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A coding single-nucleotide polymorphism in lysine demethylase KDM4A associates with increased sensitivity to mTOR inhibitors.
Capucine Van Rechem, Joshua C Black, Patricia Greninger, Yang Zhao, Carlos Donado, Brendon Ladd

Cancer Discov· March 2015

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Resistance to everolimus driven by epigenetic regulation of MYC in ER+ breast cancers.
Teeru Bihani, Scott A Ezell, Brendon Ladd, Shaun E Grosskurth, Anne Marie Mazzola

Oncotarget· February 2015

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Inhibition of homologous recombination with vorinostat synergistically enhances ganciclovir cytotoxicity.
Brendon Ladd, Jeffrey J Ackroyd, J Kevin Hicks, Christine E Canman, Sheryl A Flanagan

DNA Repair (Amst)· December 2013

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KDM4A lysine demethylase induces site-specific copy gain and rereplication of regions amplified in tumors.
Joshua C Black, Amity L Manning, Capucine Van Rechem, Jaegil Kim, Brendon Ladd

Cell· August 2013

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Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase.
Johnathan R Whetstine, Julian Ceron, Brendon Ladd, Pascale Dufourcq, Valerie Reinke

Mol Cell· May 2005

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