Publications by authors named "Brett A Howell"

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Quantitative Systems Toxicology Modeling of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Adults With Chronic Alcohol Use or Low Glutathione.
Kyunghee Yang, James J Beaudoin, Brett A Howell, James Mullin, Elham Amini

CPT Pharmacometrics Syst Pharmacol· July 2025

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Modeling and Simulation of Acetaminophen Pharmacokinetics and Hepatic Biomarkers After Overdoses of Extended-Release and Immediate-Release Formulations in Healthy Adults Using the Quantitative Systems Toxicology Software Platform DILIsym.
James J Beaudoin, Kyunghee Yang, Brett A Howell, Zackary Kenz, Vinal V Lakhani

CPT Pharmacometrics Syst Pharmacol· April 2025

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Prediction of the liver safety profile of a first-in-class myeloperoxidase inhibitor using quantitative systems toxicology modeling.
Jeffrey L Woodhead, Yeshi Gebremichael, Joyce Macwan, Irfan A Qureshi, Richard Bertz, Brett A Howell

Xenobiotica· July 2024

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Quantitative Systems Toxicology Modeling Informed Safe Dose Selection of Emvododstat in Acute Myeloid Leukemia Patients.
Kyunghee Yang, Ronald Kong, Robert Spiegel, John D Baird, Kylie O'Keefe, Brett A Howell

Clin Pharmacol Ther· March 2024

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Assessing Liver Effects of Cannabidiol and Valproate Alone and in Combination Using Quantitative Systems Toxicology.
Vinal V Lakhani, Grant Generaux, Brett A Howell, Diane M Longo, Paul B Watkins

Clin Pharmacol Ther· November 2023

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Mechanistic investigation of liver injury induced by BMS-932481, an experimental ɣ-secretase modulator.
Xiaoliang Zhuo, Brett A Howell, Hong Shen, Jeffrey L Woodhead, Kathy Mosure

Toxicol Sci· July 2023

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The Combination of a Human Biomimetic Liver Microphysiology System with BIOLOGXsym, a Quantitative Systems Toxicology (QST) Modeling Platform for Macromolecules, Provides Mechanistic Understanding of Tocilizumab- and GGF2-Induced Liver Injury.
James J Beaudoin, Lara Clemens, Mark T Miedel, Albert Gough, Fatima Zaidi, Brett A Howell

Int J Mol Sci· June 2023

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Investigating bile acid-mediated cholestatic drug-induced liver injury using a mechanistic model of multidrug resistance protein 3 (MDR3) inhibition.
James J Beaudoin, Kyunghee Yang, Jeffry Adiwidjaja, Guncha Taneja, Paul B Watkins, Brett A Howell

Front Pharmacol· January 2023

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Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling.
Jeffrey L Woodhead, Scott Q Siler, Brett A Howell, Paul B Watkins, Charles Conway

Toxicol Sci· June 2022

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A critical review of the acetaminophen preclinical carcinogenicity and tumor promotion data and their implications for its carcinogenic hazard potential.
F Jay Murray, Andrew D Monnot, David Jacobson-Kram, Samuel M Cohen, Jerry F Hardisty, Brett A Howell

Regul Toxicol Pharmacol· December 2020

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Application of the DILIsym® Quantitative Systems Toxicology drug-induced liver injury model to evaluate the carcinogenic hazard potential of acetaminophen.
Gary Eichenbaum, Kyunghee Yang, Yeshitila Gebremichael, Brett A Howell, F Jay Murray

Regul Toxicol Pharmacol· December 2020

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Assessing Effects of BHV-0223 40 mg Zydis Sublingual Formulation and Riluzole 50 mg Oral Tablet on Liver Function Test Parameters Utilizing DILIsym.
Diane M Longo, Lisl K M Shoda, Brett A Howell, Vladimir Coric, Robert M Berman

Toxicol Sci· June 2020

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Quantitative systems toxicology (QST) reproduces species differences in PF-04895162 liver safety due to combined mitochondrial and bile acid toxicity.
Grant Generaux, Vinal V Lakhani, Yuching Yang, Sashi Nadanaciva, Luping Qiu, Brett A Howell

Pharmacol Res Perspect· December 2019

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Quantitative Systems Toxicology Analysis of In Vitro Mechanistic Assays Reveals Importance of Bile Acid Accumulation and Mitochondrial Dysfunction in TAK-875-Induced Liver Injury.
Diane M Longo, Jeffrey L Woodhead, Paul Walker, Krisztina Herédi-Szabó, Károly Mogyorósi, Brett A Howell

Toxicol Sci· February 2019

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Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling.
Jeffrey L Woodhead, Kyunghee Yang, David Oldach, Chris MacLauchlin, Prabhavathi Fernandes, Brett A Howell

Pharm Res· February 2019

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Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity.
Christina Battista, Kyunghee Yang, Simone H Stahl, Jerome T Mettetal, Paul B Watkins, Brett A Howell

Toxicol Sci· November 2018

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Prediction of Safety Margin and Optimization of Dosing Protocol for a Novel Antibiotic using Quantitative Systems Pharmacology Modeling.
Jeffrey L Woodhead, Franziska Paech, Martina Maurer, Marc Engelhardt, Anne H Schmitt-Hoffmann, Brett A Howell

Clin Transl Sci· September 2018

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Mechanisms of hepatotoxicity associated with the monocyclic β-lactam antibiotic BAL30072.
Franziska Paech, Simon Messner, Jochen Spickermann, Mathias Wind, Anne-Hortense Schmitt-Hoffmann, Brett A Howell

Arch Toxicol· November 2017

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Mechanistic Modelling of Drug-Induced Liver Injury: Investigating the Role of Innate Immune Responses.
Lisl Km Shoda, Christina Battista, Scott Q Siler, David S Pisetsky, Paul B Watkins, Brett A Howell

Gene Regul Syst Bio· May 2017

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The role of quantitative systems pharmacology modeling in the prediction and explanation of idiosyncratic drug-induced liver injury.
Jeffrey L Woodhead, Paul B Watkins, Brett A Howell, Scott Q Siler, Lisl K M Shoda

Drug Metab Pharmacokinet· February 2017

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Application of a Mechanistic Model to Evaluate Putative Mechanisms of Tolvaptan Drug-Induced Liver Injury and Identify Patient Susceptibility Factors.
Jeffrey L Woodhead, William J Brock, Sharin E Roth, Susan E Shoaf, Kim L R Brouwer, Brett A Howell

Toxicol Sci· January 2017

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Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury.
Kyunghee Yang, Cen Guo, Jeffrey L Woodhead, Robert L St Claire, Paul B Watkins, Brett A Howell

J Pharm Sci· February 2016

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Exploring BSEP inhibition-mediated toxicity with a mechanistic model of drug-induced liver injury.
Jeffrey L Woodhead, Kyunghee Yang, Scott Q Siler, Paul B Watkins, Kim L R Brouwer, Brett A Howell

Front Pharmacol· November 2014

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Use of a systems model of drug-induced liver injury (DILIsym(®)) to elucidate the mechanistic differences between acetaminophen and its less-toxic isomer, AMAP, in mice.
Brett A Howell, Scott Q Siler, Paul B Watkins

Toxicol Lett· April 2014

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Linking physiology to toxicity using DILIsym®, a mechanistic mathematical model of drug-induced liver injury.
Lisl K M Shoda, Jeffrey L Woodhead, Scott Q Siler, Paul B Watkins, Brett A Howell

Biopharm Drug Dispos· January 2014

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