Publications by authors named "Brett Hurst"

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Broad-Spectrum Peptidomimetic Inhibitors of Norovirus and Coronavirus 3C-like Proteases.
Margaret A Brimble, Louise A Stubbing, Yann O Hermant, Sung-Hyun Yang, Jonathan G Hubert, Brett L Hurst

ACS Infect Dis· December 2025

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Structure-Activity Relationship Studies Towards Analogues of Pleconaril as Novel Enterovirus-D68 Capsid-Targeting Antivirals.
David L Cousins, Ed J Griffen, Jessica Stacey, Alpha A Lee, Yuliia Filimonova, Brett L Hurst

bioRxiv· August 2025

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Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.
Jamison B Tuttle, Christophe Allais, Charlotte M N Allerton, Annaliesa S Anderson, Joel T Arcari, Brett L Hurst

J Med Chem· April 2025

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Differences in Susceptibility to SARS-CoV-2 Infection Among Transgenic hACE2-Hamster Founder Lines.
Scott A Gibson, Yanan Liu, Rong Li, Brett L Hurst, Zhiqiang Fan

Viruses· October 2024

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A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Charlotte M N Allerton, Joel T Arcari, Lisa M Aschenbrenner, Melissa Avery, Bruce M Bechle, Brett L Hurst

J Med Chem· August 2024

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Discovery of SARS-CoV-2 papain-like protease (PL) inhibitors with efficacy in a murine infection model.
Michelle R Garnsey, Matthew C Robinson, Luong T Nguyen, Rhonda Cardin, Joseph Tillotson, Brett Hurst

Sci Adv· August 2024

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An intranasal nanoparticle STING agonist protects against respiratory viruses in animal models.
Ankita Leekha, Arash Saeedi, Monish Kumar, K M Samiur Rahman Sefat, Melisa Martinez-Paniagua, Brett L Hurst

Nat Commun· July 2024

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Multi-antigen intranasal vaccine protects against challenge with sarbecoviruses and prevents transmission in hamsters.
Ankita Leekha, Arash Saeedi, K M Samiur Rahman Sefat, Monish Kumar, Melisa Martinez-Paniagua, Brett Hurst

Nat Commun· July 2024

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Meeting report: 36th International Conference on Antiviral Research in Lyon, France - March 13-17, 2023.
Jessica R Spengler, Kara Carter, Leen Delang, David Durantel, Brian B Gowen, Brett Hurst

Antiviral Res· September 2023

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An Advax-CpG adjuvanted recombinant H5 hemagglutinin vaccine protects mice against lethal influenza infection.
Yoshikazu Honda-Okubo, E Bart Tarbet, Brett L Hurst, Nikolai Petrovsky

Vaccine· September 2023

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Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5.
Thomas R Lane, Jianing Fu, Barbara Sherry, Bart Tarbet, Brett L Hurst

Antiviral Res· August 2023

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An Advax-CpG55.2 adjuvanted recombinant hemagglutinin vaccine provides immunity against H7N9 influenza in adult and neonatal mice.
Yoshikazu Honda-Okubo, Isaac G Sakala, Greiciely André, E Bart Tarbet, Brett L Hurst

Vaccine· August 2023

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An Isomer of Galidesivir That Potently Inhibits Influenza Viruses and Members of the Order.
Kevin J Sparrow, Rinu Shrestha, James M Wood, Keith Clinch, Brett L Hurst

ACS Med Chem Lett· April 2023

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Human IVIG treatment in a neurological disease model for Enterovirus A71 infection in 28-day-old AG129 mice.
Christopher J Peterson, Brett L Hurst, W Joseph Evans, Arnaud J Van Wettere, Scott A Gibson

Virology· March 2023

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Potent and selective covalent inhibition of the papain-like protease from SARS-CoV-2.
Brian C Sanders, Suman Pokhrel, Audrey D Labbe, Irimpan I Mathews, Connor J Cooper, Brett L Hurst

Nat Commun· March 2023

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Anti-SARS-CoV-2 activity of targeted kinase inhibitors: Repurposing clinically available drugs for COVID-19 therapy.
RuthMabel Boytz, Mikołaj Słabicki, Sita Ramaswamy, J J Patten, Charles Zou, Brett L Hurst

J Med Virol· January 2023

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TEMPOL inhibits SARS-CoV-2 replication and development of lung disease in the Syrian hamster model.
Nunziata Maio, Sara Cherry, David C Schultz, Brett L Hurst, W Marston Linehan

iScience· October 2022

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Programmable antivirals targeting critical conserved viral RNA secondary structures from influenza A virus and SARS-CoV-2.
Rachel J Hagey, Menashe Elazar, Edward A Pham, Siqi Tian, Lily Ben-Avi, Brett L Hurst

Nat Med· September 2022

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Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice.
Ana C Puhl, Giovanni F Gomes, Samara Damasceno, Ethan J Fritch, James A Levi, Brett L Hurst

ACS Omega· September 2022

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Potent and Selective Covalent Inhibition of the Papain-like Protease from SARS-CoV-2.
Brian Sanders, Suman Pokhrel, Audrey Labbe, Irimpan Mathews, Connor Cooper, Brett Hurst

Res Sq· July 2022

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Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19.
Hengrui Liu, Sho Iketani, Arie Zask, Nisha Khanizeman, Eva Bednarova, Brett L Hurst

Nat Commun· April 2022

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Vandetanib Reduces Inflammatory Cytokines and Ameliorates COVID-19 in Infected Mice.
Ana C Puhl, Giovanni F Gomes, Samara Damasceno, Ethan J Fritch, James A Levi, Brett L Hurst

bioRxiv· December 2021

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Visible blue light inhibits infection and replication of SARS-CoV-2 at doses that are well-tolerated by human respiratory tissue.
Nathan Stasko, Jacob F Kocher, Abigail Annas, Ibrahim Henson, Theresa S Seitz, Brett L Hurst

Sci Rep· October 2021

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Inhibits SARS-CoV-2 Replication and Reduces Lung Inflammation.
Kameswari S Konduri, Ram Pattisapu, Jogi Pattisapu, Girija G Konduri, John Zwetchkenbaum, Brett L Hurst

Arch Pharmacol Ther· January 2021

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