Publications by authors named "Jamison B Tuttle"

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Discovery of Nirmatrelvir (PF-07321332): A Potent, Orally Active Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS CoV-2) Main Protease.
Jamison B Tuttle, Christophe Allais, Charlotte M N Allerton, Annaliesa S Anderson, Joel T Arcari

J Med Chem· April 2025

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Discovery of PF-07265028, A Selective Small Molecule Inhibitor of Hematopoietic Progenitor Kinase 1 (HPK1) for the Treatment of Cancer.
Rebecca A Gallego, Sujin Cho-Schultz, Matthew Del Bel, Anne-Marie Dechert-Schmitt, Joyann S Donaldson, Jamison B Tuttle

J Med Chem· December 2024

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A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19.
Charlotte M N Allerton, Joel T Arcari, Lisa M Aschenbrenner, Melissa Avery, Bruce M Bechle, Jamison B Tuttle

J Med Chem· August 2024

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An inverse agonist of orphan receptor GPR61 acts by a G protein-competitive allosteric mechanism.
Joshua A Lees, João M Dias, Francis Rajamohan, Jean-Philippe Fortin, Rebecca O'Connor, Jamison B Tuttle

Nat Commun· September 2023

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Photoaffinity Labeling and Quantitative Chemical Proteomics Identify LXRβ as the Functional Target of Enhancers of Astrocytic apoE.
Uthpala Seneviratne, Zhen Huang, Christopher W Am Ende, Todd W Butler, Leah Cleary, Jamison B Tuttle

Cell Chem Biol· February 2021

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Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition.
Cheng Chang, Kari R Fonseca, Cheryl Li, Weldon Horner, Laura E Zawadzke, Jamison B Tuttle

Mol Pharmacol· August 2018

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Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.
Antonia F Stepan, Michelle M Claffey, Matthew R Reese, Gayatri Balan, Gabriela Barreiro, Jamison B Tuttle

J Med Chem· September 2017

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Challenges and Opportunities in the Discovery of New Therapeutics Targeting the Kynurenine Pathway.
Amy B Dounay, Jamison B Tuttle, Patrick R Verhoest

J Med Chem· November 2015

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Discovery and preclinical characterization of 1-methyl-3-(4-methylpyridin-3-yl)-6-(pyridin-2-ylmethoxy)-1H-pyrazolo-[3,4-b]pyrazine (PF470): a highly potent, selective, and efficacious metabotropic glutamate receptor 5 (mGluR5) negative allosteric modulator.
Lei Zhang, Gayatri Balan, Gabriela Barreiro, Brian P Boscoe, Lois K Chenard, Jamison B Tuttle

J Med Chem· February 2014

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PF-04859989 as a template for structure-based drug design: identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency.
Amy B Dounay, Marie Anderson, Bruce M Bechle, Edelweiss Evrard, Xinmin Gan, Jamison B Tuttle

Bioorg Med Chem Lett· April 2013

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Structure-Based Design of Irreversible Human KAT II Inhibitors: Discovery of New Potency-Enhancing Interactions.
Jamison B Tuttle, Marie Anderson, Bruce M Bechle, Brian M Campbell, Cheng Chang

ACS Med Chem Lett· January 2013

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Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive disorders.
Patrick R Verhoest, Kari R Fonseca, Xinjun Hou, Caroline Proulx-Lafrance, Michael Corman, Jamison B Tuttle

J Med Chem· November 2012

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Discovery of Brain-Penetrant, Irreversible Kynurenine Aminotransferase II Inhibitors for Schizophrenia.
Amy B Dounay, Marie Anderson, Bruce M Bechle, Brian M Campbell, Michelle M Claffey, Jamison B Tuttle

ACS Med Chem Lett· March 2012

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A general strategy for the synthesis of cyclic N-aryl hydroxamic acids via partial nitro group reduction.
Laura A McAllister, Bruce M Bechle, Amy B Dounay, Edelweiss Evrard, Xinmin Gan, Jamison B Tuttle

J Org Chem· May 2011

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Organocatalytic transfer hydrogenation of cyclic enones.
Jamison B Tuttle, Stéphane G Ouellet, David W C MacMillan

J Am Chem Soc· October 2006

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Enantioselective organocatalytic hydride reduction.
Stéphane G Ouellet, Jamison B Tuttle, David W C MacMillan

J Am Chem Soc· January 2005

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