Publications by authors named "Brian B Tuch"

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Global signal peptide profiling reveals principles of selective Sec61 inhibition.
Nicole A Wenzell, Brian B Tuch, Dustin L McMinn, Matthew J Lyons, Christopher J Kirk

Nat Chem Biol· September 2024

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Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses.
Tony Muchamuel, R Andrea Fan, Janet L Anderl, Darrin J Bomba, Henry W B Johnson, Brian B Tuch

Front Immunol· March 2023

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RET Solvent Front Mutations Mediate Acquired Resistance to Selective RET Inhibition in RET-Driven Malignancies.
Benjamin J Solomon, Lavinia Tan, Jessica J Lin, Stephen Q Wong, Sebastian Hollizeck, Brian B Tuch

J Thorac Oncol· April 2020

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Resistance to TRK inhibition mediated by convergent MAPK pathway activation.
Emiliano Cocco, Alison M Schram, Amanda Kulick, Sandra Misale, Helen H Won, Brian B Tuch

Nat Med· September 2019

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Emergence and Targeting of Acquired and Hereditary Resistance to Multikinase RET Inhibition in Patients With RET-Altered Cancer.
Lori J Wirth, Takashi Kohno, Hibiki Udagawa, Shingo Matsumoto, Genichiro Ishii, Brian B Tuch

JCO Precis Oncol· September 2019

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ETV6-NTRK3 induces aggressive acute lymphoblastic leukemia highly sensitive to selective TRK inhibition.
Kathryn G Roberts, Laura J Janke, Yaqi Zhao, Aman Seth, Jing Ma, Brian B Tuch

Blood· August 2018

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Oncogenic TRK fusions are amenable to inhibition in hematologic malignancies.
Justin Taylor, Dean Pavlick, Akihide Yoshimi, Christina Marcelus, Stephen S Chung, Brian B Tuch

J Clin Invest· August 2018

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Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.
Theodore W Laetsch, Steven G DuBois, Leo Mascarenhas, Brian Turpin, Noah Federman, Brian B Tuch

Lancet Oncol· May 2018

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Efficacy of Larotrectinib in TRK Fusion-Positive Cancers in Adults and Children.
Alexander Drilon, Theodore W Laetsch, Shivaani Kummar, Steven G DuBois, Ulrik N Lassen, Brian B Tuch

N Engl J Med· February 2018

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A Next-Generation TRK Kinase Inhibitor Overcomes Acquired Resistance to Prior TRK Kinase Inhibition in Patients with TRK Fusion-Positive Solid Tumors.
Alexander Drilon, Ramamoorthy Nagasubramanian, James F Blake, Nora Ku, Brian B Tuch

Cancer Discov· September 2017

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An Oncogenic NTRK Fusion in a Patient with Soft-Tissue Sarcoma with Response to the Tropomyosin-Related Kinase Inhibitor LOXO-101.
Robert C Doebele, Lara E Davis, Aria Vaishnavi, Anh T Le, Adriana Estrada-Bernal, Brian B Tuch

Cancer Discov· October 2015

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Intersecting transcription networks constrain gene regulatory evolution.
Trevor R Sorrells, Lauren N Booth, Brian B Tuch, Alexander D Johnson

Nature· July 2015

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Nucleosome regulatory dynamics in response to TGFβ.
Stefan Enroth, Robin Andersson, Madhusudhan Bysani, Ola Wallerman, Stefan Termén, Brian B Tuch

Nucleic Acids Res· June 2014

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A recently evolved transcriptional network controls biofilm development in Candida albicans.
Clarissa J Nobile, Emily P Fox, Jeniel E Nett, Trevor R Sorrells, Quinn M Mitrovich, Brian B Tuch

Cell· January 2012

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Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Fuchou Tang, Catalin Barbacioru, Ellen Nordman, Siqin Bao, Caroline Lee, Brian B Tuch

PLoS One· November 2011

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An iron homeostasis regulatory circuit with reciprocal roles in Candida albicans commensalism and pathogenesis.
Changbin Chen, Kalyan Pande, Sarah D French, Brian B Tuch, Suzanne M Noble

Cell Host Microbe· August 2011

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Extensive DNA-binding specificity divergence of a conserved transcription regulator.
Christopher R Baker, Brian B Tuch, Alexander D Johnson

Proc Natl Acad Sci U S A· May 2011

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The developmental transcriptome of Drosophila melanogaster.
Brenton R Graveley, Angela N Brooks, Joseph W Carlson, Michael O Duff, Jane M Landolin, Brian B Tuch

Nature· March 2011

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Intercalation of a new tier of transcription regulation into an ancient circuit.
Lauren N Booth, Brian B Tuch, Alexander D Johnson

Nature· December 2010

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Evolution of yeast noncoding RNAs reveals an alternative mechanism for widespread intron loss.
Quinn M Mitrovich, Brian B Tuch, Francisco M De La Vega, Christine Guthrie, Alexander D Johnson

Science· November 2010

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The transcriptomes of two heritable cell types illuminate the circuit governing their differentiation.
Brian B Tuch, Quinn M Mitrovich, Oliver R Homann, Aaron D Hernday, Cinna K Monighetti

PLoS Genet· August 2010

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Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations.
Brian B Tuch, Rebecca R Laborde, Xing Xu, Jian Gu, Christina B Chung

PLoS One· February 2010

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Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Liam J Holt, Brian B Tuch, Judit Villén, Alexander D Johnson, Steven P Gygi

Science· September 2009

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mRNA-Seq whole-transcriptome analysis of a single cell.
Fuchou Tang, Catalin Barbacioru, Yangzhou Wang, Ellen Nordman, Clarence Lee, Brian B Tuch

Nat Methods· May 2009

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Measuring the prevalence of regional mutation rates: an analysis of silent substitutions in mammals, fungi, and insects.
Aleah K Fox, Brian B Tuch, Jeffrey H Chuang

BMC Evol Biol· June 2008

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