Publications by authors named "Brian Blagg"

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Design, synthesis, and biological properties exhibited by 1,2,3-triazole based Grp94-selective inhibitors.
Hao Xu, Dustin J E Huard, Elijah Dunn, Lucas A Chalfoun, Felix Adulley, Brian S J Blagg

Eur J Med Chem· February 2026

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Multi-omic integration identifies broad drug resistance mechanisms and strategies to therapeutically reprogram cancer cells.
Ian Mersich, Brian S J Blagg, Aktar Ali

iScience· January 2026

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Biotinylated Hsp90β-selective inhibitors.
Chaitanya Kondam, Nitin Sharma, Gaya K Amarasinge, Brian S J Blagg

Bioorg Med Chem Lett· December 2025

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TRAP1 and its therapeutic potential.
Andrew Gutierrez, Jason Archdeacon, Brian S J Blagg

Bioorg Med Chem Lett· December 2025

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Hsp90β-Selective Inhibitors: Probing the Solvent-Accessible Frontier.
Terin D'Amico, Michael A Serwetnyk, Xiaozheng Dou, Ian Mersich, Deborah Barlow, Brian S J Blagg

ChemMedChem· December 2025

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Optimization of Hsp90/Aha1 Small-Molecule Disruptors Via the Evaluation of Amide Bioisosteres.
Kevin C Catalfano, Bradley M Keegan, Brian S J Blagg

ACS Med Chem Lett· December 2025

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Synergistic Disruption of Survival and Metastatic Potential in Esophageal Adenocarcinoma Cells Through Combined Inhibition of HIF1α and CD73.
Ian Mersich, Alexander Malmberg, Eahsanul Anik, Md Sazzad Hassan, Urs von Holzen, Brian S J Blagg

Cancers (Basel)· December 2025

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Optimization of an Hsp90β-selective inhibitor via exploration of the Hsp90 N-terminal ATP-binding pocket.
Michael A Serwetnyk, Taddäus Strunden, Ian Mersich, Deborah Barlow, Terin D'Amico, Brian S J Blagg

Eur J Med Chem· November 2025

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Integrative Multi-Omics Analyses Reveal Mechanisms of Resistance to Hsp90β-Selective Inhibition.
Ian Mersich, Eahsanul Anik, Aktar Ali, Brian S J Blagg

Cancers (Basel)· October 2025

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The Hsp90β Isoform: An Attractive Target for Drug Development.
Subhabrata Chaudhury, Terin D'Amico, Brian S J Blagg

Med Res Rev· September 2025

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Proteomic Analysis of Hsp90β-Selective Inhibitors Against Triple-Negative Breast Cancer to Gain a Mechanistic Insight.
Tyelor S Reynolds, Daniel D Hu, Simon D Weaver, Emma C Ronck, Sanket J Mishra, Brian S J Blagg

Mol Cell Proteomics· September 2025

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[C]HSP990 PET as a translational tool to investigate the role of Hsp90 in tumours and support the development of Hsp90 therapeutics.
Romy Cools, Valeria Narykina, Koen Vermeulen, Sanket J Mishra, Brian S J Blagg

EJNMMI Radiopharm Chem· September 2025

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Glucose-regulated protein 94 (Grp94/gp96) in viral pathogenesis: Insights into its role and therapeutic potentials.
Hao Xu, Brian S J Blagg

Eur J Med Chem· August 2025

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Hsp90 and Isoform-Selective Inhibitors as Sensitizers for Cancer Immunotherapy.
Shiying Jia, Neeraj Maurya, Brian S J Blagg, Xin Lu

Pharmaceuticals (Basel)· July 2025

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5,7-Dimethoxychroman-3-yl 4-methoxybenzoate Has a Unique Effect upon the Modulation of Mutant Cardiac Muscle Thin Filament Function and Dynamics due to Phosphorylation of Troponin I.
Zeyu Yang, Alice M Sheehan, Mary Papadaki, Andrew E Messer, Brian S J Blagg

ACS Pharmacol Transl Sci· May 2025

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Engineered Age-Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments.
Jun Yang, Lauren Hawthorne, Sharon Stack, Brian Blagg, Aktar Ali

Adv Healthc Mater· March 2025

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C-Terminal Hsp90 Inhibitors Overcome MEK and BRAF Inhibitor Resistance in Melanoma.
Chitra Subramanian, Katie K Hohenberger, Ang Zuo, Eric Cousineau, Brian Blagg

J Cell Mol Med· March 2025

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Conformationally Restricted Grp94-Selective Inhibitors.
Hao Xu, Kyler Pugh, Brian S J Blagg

ACS Omega· January 2025

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Assessment of Hsp90β-selective inhibitor safety and on-target effects.
Tyelor S Reynolds, Sanket J Mishra, Brian S J Blagg

Sci Rep· January 2025

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The Investigation of Hsp90C-Terminal Inhibitors Containing Amide Bioisosteres.
Eva Amatya, Chitra Subramanian, Reagan Long, Kelli McNamara, Mark S Cohen, Brian S J Blagg

ChemMedChem· December 2024

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The role of Aha1 in cancer and neurodegeneration.
Brian S J Blagg, Kevin C Catalfano

Front Mol Neurosci· December 2024

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Extracellular heat shock protein 90 alpha (eHsp90α)'s role in cancer progression and the development of therapeutic strategies.
Tyelor S Reynolds, Brian S J Blagg

Eur J Med Chem· November 2024

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Molecular determinants of phospholipid treatment to reduce intracellular cholesterol accumulation in NPC1 deficiency.
Shikun Deng, Ting-Ann Liu, Olga Ilnytska, Tamara Allada, Angelina Fomina, Brian S J Blagg

J Biol Chem· November 2024

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Engineered Age-Mimetic Breast Cancer Models Reveal Differential Drug Responses in Young and Aged Microenvironments.
Jun Yang, Lauren Hawthorne, Sharon Stack, Brian Blagg, Aktar Ali

bioRxiv· October 2024

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Mutant induced neurons and humanized mice enable identification of Niemann-Pick type C1 proteostatic therapies.
Ruth D Azaria, Adele B Correia, Kylie J Schache, Manuela Zapata, Koralege C Pathmasiri, Brian Sj Blagg

JCI Insight· August 2024

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