Publications by authors named "Brian Chamberlain"

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Multigram Preparation of BRD4780 Enantiomers and Assignment of Absolute Stereochemistry.
Brian T Chamberlain, Mathilde Vincent, Jordan Nafie, Peter Müller, Anna Greka

J Org Chem· March 2021

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Completing the β,γ-CXY-dNTP Stereochemical Probe Toolkit: Synthetic Access to the dCTP Diastereomers and P and F NMR Correlations with Absolute Configurations.
Pouya Haratipour, Corinne Minard, Maryam Nakhjiri, Amirsoheil Negahbani, Brian T Chamberlain

J Org Chem· November 2020

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A High-Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury.
Maria Kost-Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, Brian T Chamberlain, Moran Dvela-Levitt

Cell Rep Med· November 2020

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A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.
Maria Alimova, Eriene-Heidi Sidhom, Abhigyan Satyam, Moran Dvela-Levitt, Michelle Melanson, Brian T Chamberlain

bioRxiv· June 2020

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Discovery of indole inhibitors of chemokine receptor 9 (CCR9).
Bhaumik A Pandya, Christian Baber, Audrey Chan, Brian Chamberlain, Haoqun Chandonnet

Bioorg Med Chem Lett· July 2016

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Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.
Jason B Cross, Jing Zhang, Qingyi Yang, Michael F Mesleh, Jan Antoinette C Romero, Brian Chamberlain

ACS Med Chem Lett· April 2016

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Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.
Jing Zhang, Qingyi Yang, Jason B Cross, Jan Antoinette C Romero, Katherine M Poutsiaka, Brian Chamberlain

J Med Chem· November 2015

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Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.
Jing Zhang, Qingyi Yang, Jan Antoinette C Romero, Jason Cross, Bin Wang, Brian Chamberlain

ACS Med Chem Lett· October 2015

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Biarylsulfonamide CCR9 inhibitors for inflammatory bowel disease.
Jing Zhang, Jan Romero, Audrey Chan, Jennifer Goss, Sabrina Stucka, Brian Chamberlain

Bioorg Med Chem Lett· September 2015

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Synthesis and Bioactivity of a Brasilicardin A Analogue Featuring a Simplified Core.
Michael E Jung, Brian T Chamberlain, Pierre Koch, Kayvan R Niazi

Org Lett· July 2015

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The LXR-Idol axis differentially regulates plasma LDL levels in primates and mice.
Cynthia Hong, Stephanie M Marshall, Allison L McDaniel, Mark Graham, Joseph D Layne, Brian T Chamberlain

Cell Metab· November 2014

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The macrophage LBP gene is an LXR target that promotes macrophage survival and atherosclerosis.
Tamer Sallam, Ayaka Ito, Xin Rong, Jason Kim, Caroline van Stijn, Brian T Chamberlain

J Lipid Res· June 2014

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Structure-Activity Relationship of Semicarbazone EGA Furnishes Photoaffinity Inhibitors of Anthrax Toxin Cellular Entry.
Michael E Jung, Brian T Chamberlain, Chi-Lee C Ho, Eugene J Gillespie, Kenneth A Bradley

ACS Med Chem Lett· April 2014

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Transition state in DNA polymerase β catalysis: rate-limiting chemistry altered by base-pair configuration.
Keriann Oertell, Brian T Chamberlain, Yue Wu, Elena Ferri, Boris A Kashemirov

Biochemistry· March 2014

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Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.
Eugene J Gillespie, Chi-Lee C Ho, Kavitha Balaji, Daniel L Clemens, Gang Deng, Brian T Chamberlain

Proc Natl Acad Sci U S A· December 2013

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LXRs regulate ER stress and inflammation through dynamic modulation of membrane phospholipid composition.
Xin Rong, Carolyn J Albert, Cynthia Hong, Mark A Duerr, Brian T Chamberlain

Cell Metab· November 2013

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An essential requirement for the SCAP/SREBP signaling axis to protect cancer cells from lipotoxicity.
Kevin J Williams, Joseph P Argus, Yue Zhu, Moses Q Wilks, Beth N Marbois, Brian T Chamberlain

Cancer Res· May 2013

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Stereospecific formation of a ternary complex of (S)-α,β-fluoromethylene-dATP with DNA pol β.
Brian T Chamberlain, Vinod K Batra, William A Beard, Anastasia P Kadina, David D Shock

Chembiochem· March 2012

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α-Azido bisphosphonates: synthesis and nucleotide analogues.
Brian T Chamberlain, Thomas G Upton, Boris A Kashemirov, Charles E McKenna

J Org Chem· June 2011

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Synthesis and sensing of bisphosphonophosphate alkyl monoesters: A novel class of compounds for the study of nucleoside 5'-triphosphate chemistry.
Brian T Chamberlain, Jorge Osuna, Boris A Kashemirov, Charles E McKenna

Phosphorus Sulfur Silicon Relat Elem· April 2011

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