Publications by authors named "Jan Romero"

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Rational design of a new antibiotic class for drug-resistant infections.
Thomas F Durand-Reville, Alita A Miller, John P O'Donnell, Xiaoyun Wu, Mark A Sylvester, Jan A Romero

Nature· September 2021

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N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
Takeru Furuya, Adam B Shapiro, Janelle Comita-Prevoir, Eric J Kuenstner, Jing Zhang, Jan A C Romero

Bioorg Med Chem· December 2020

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Discovery of an Orally Available Diazabicyclooctane Inhibitor (ETX0282) of Class A, C, and D Serine β-Lactamases.
Thomas F Durand-Réville, Janelle Comita-Prevoir, Jing Zhang, Xiaoyun Wu, Tricia L May-Dracka, Jan Antoinette C Romero

J Med Chem· November 2020

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In-silico guided discovery of novel CCR9 antagonists.
Xin Zhang, Jason B Cross, Jan Romero, Alexander Heifetz, Eric Humphries

J Comput Aided Mol Des· April 2018

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Structure-based discovery of LpxC inhibitors.
Jing Zhang, Audrey Chan, Blaise Lippa, Jason B Cross, Christopher Liu, Jan Antoinette C Romero

Bioorg Med Chem Lett· April 2017

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Discovery of indole inhibitors of chemokine receptor 9 (CCR9).
Bhaumik A Pandya, Christian Baber, Audrey Chan, Brian Chamberlain, Haoqun Chandonnet, Jan Romero

Bioorg Med Chem Lett· July 2016

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Discovery of Brigatinib (AP26113), a Phosphine Oxide-Containing, Potent, Orally Active Inhibitor of Anaplastic Lymphoma Kinase.
Wei-Sheng Huang, Shuangying Liu, Dong Zou, Mathew Thomas, Yihan Wang, Jan Romero

J Med Chem· May 2016

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Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.
Jason B Cross, Jing Zhang, Qingyi Yang, Michael F Mesleh, Jan Antoinette C Romero

ACS Med Chem Lett· April 2016

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Discovery of Azaindole Ureas as a Novel Class of Bacterial Gyrase B Inhibitors.
Jing Zhang, Qingyi Yang, Jason B Cross, Jan Antoinette C Romero, Katherine M Poutsiaka

J Med Chem· November 2015

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Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.
Jing Zhang, Qingyi Yang, Jan Antoinette C Romero, Jason Cross, Bin Wang

ACS Med Chem Lett· October 2015

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Biarylsulfonamide CCR9 inhibitors for inflammatory bowel disease.
Jing Zhang, Jan Romero, Audrey Chan, Jennifer Goss, Sabrina Stucka

Bioorg Med Chem Lett· September 2015

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Discovery of 5-(arenethynyl) hetero-monocyclic derivatives as potent inhibitors of BCR-ABL including the T315I gatekeeper mutant.
Mathew Thomas, Wei-Sheng Huang, David Wen, Xiaotian Zhu, Yihan Wang, Jan Romero

Bioorg Med Chem Lett· June 2011

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Discovery of 3-[2-(imidazo[1,2-b]pyridazin-3-yl)ethynyl]-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide (AP24534), a potent, orally active pan-inhibitor of breakpoint cluster region-abelson (BCR-ABL) kinase including the T315I gatekeeper mutant.
Wei-Sheng Huang, Chester A Metcalf, Raji Sundaramoorthi, Yihan Wang, Dong Zou, Jan Romero

J Med Chem· June 2010

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Enantioselective synthesis of protected amines by the catalytic asymmetric addition of hydrazoic acid to ketenes.
Xing Dai, Takashi Nakai, Jan A C Romero, Gregory C Fu

Angew Chem Int Ed Engl· September 2007

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Stereochemistry of nucleophilic substitution reactions depending upon substituent: evidence for electrostatic stabilization of pseudoaxial conformers of oxocarbenium ions by heteroatom substituents.
Leticia Ayala, Claudia G Lucero, Jan Antoinette C Romero, Sarah A Tabacco, K A Woerpel

J Am Chem Soc· December 2003

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Lanthanocene catalysts in selective organic synthesis.
Gary A Molander, Jan Antoinette C Romero

Chem Rev· June 2002

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